PUBLICATION
Identification and expression of zebrafish Iroquois homeobox gene irx1
- Authors
- Cheng, C.W., Hui, C.C., Strähle, U., and Cheng, S.H.
- ID
- ZDB-PUB-011108-4
- Date
- 2001
- Source
- Development genes and evolution 211(8-9): 442-444 (Journal)
- Registered Authors
- Cheng, Shuk Han, Strähle, Uwe
- Keywords
- tectum; tegmentum; trigeminal ganglia; rhombomere; homeobox gene
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Brain/embryology
- Brain/metabolism
- Cloning, Molecular
- Conserved Sequence
- Gene Expression Regulation, Developmental
- Homeodomain Proteins/chemistry
- Homeodomain Proteins/genetics*
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Transcription Factors/chemistry
- Transcription Factors/genetics*
- Zebrafish/embryology*
- Zebrafish/genetics*
- Zebrafish Proteins/genetics
- PubMed
- 11685579 Full text @ Dev. Genes Evol.
Citation
Cheng, C.W., Hui, C.C., Strähle, U., and Cheng, S.H. (2001) Identification and expression of zebrafish Iroquois homeobox gene irx1. Development genes and evolution. 211(8-9):442-444.
Abstract
Iroquois homeoproteins are prepatterning factors that positively regulate proneural genes and control neurogenesis. We have identified a zebrafish Iroquois gene, irx1, which is highly homologous to Xenopus Xiro1, Gallus c-Irx1 and mouse Irx1. Expression of irx1 was initially detected at the bud stage. By 16 h post-fertilization (hpf), irx1 expression was exclusively limited to the prospective midbrain and hindbrain. By 24 hpf, irx1 expression was clearly detected in the acousticovestibual ganglia, tectum, tegmentum, cerebellum and rhombomere 1 but not in rhombomere 2 or mid-hindbrain boundary.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping