PUBLICATION
The impact of musk ketone on reproduction in zebrafish (Danio rerio)
- Authors
- Carlsson, G., Orn, S., Andersson, P.L., Soderstrom, H., and Norrgren, L.
- ID
- ZDB-PUB-010724-4
- Date
- 2000
- Source
- Marine Environmental Research 50(1-5): 237-241 (Journal)
- Registered Authors
- Norrgren, Leif
- Keywords
- Danio rerio, reproduction, musk ketone, fresh water fish, nitro musk, xylene
- MeSH Terms
-
- Animals
- Body Weight/drug effects
- Female
- Male
- Ovulation/drug effects
- Perfume/toxicity*
- Reproduction/drug effects*
- Water Pollutants, Chemical/toxicity*
- Xylenes/toxicity*
- Zebrafish/physiology*
- PubMed
- 11460697 Full text @ Mar. Environ. Res.
Citation
Carlsson, G., Orn, S., Andersson, P.L., Soderstrom, H., and Norrgren, L. (2000) The impact of musk ketone on reproduction in zebrafish (Danio rerio). Marine Environmental Research. 50(1-5):237-241.
Abstract
Nitro musks ale a group of nitrated benzenes mainly used by the fragrance industry as a substitute for natural musk. Two of the most common nitro musks, musk xylene and musk ketone, have been detected in water, fish, human adipose tissue, as well as inhuman breast milk. In this study, female zebrafish were dietary-exposed to musk ketone, prior to spawning with unexposed males. The fish were exposed for 8 weeks at two different dose levels. Accumulation of the compound in the fish as well as reproductive success were studied. Exposed females had reduced body weight and length, as well as reduced liver-and gonad somatic index. The results from the reproduction study showed a dose-dependent reduction in fecundity. Early life-stage mortality was increased and the median survival time was reduced. In addition, an embryo/larvae toxicity test was performed, using newly fertilized zebrafish eggs from unexposed parental fish. Eggs were exposed to a series of different concentrations of musk ketone via the surrounding water. A NOEC value of 10 mug/l and a LOEC value of 33 mug/l was determined. Conclusively, the present study clearly shows that musk ketone negatively affects reproduction and early life-stage survival in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping