PUBLICATION

Nadine Dobrovolskaia-Zavadskaia and the dawn of developmental genetics

Authors

Korzh, V. and Grunwald, D.

ID

ZDB-PUB-010718-41

Date

2001

Source

BioEssays : news and reviews in molecular, cellular and developmental biology 23(4): 365-371 (Review)

Registered Authors

Grunwald, David, Korzh, Vladimir

Keywords

T-box genes, mesoderm formation, floor plate, zebrafish, mouse, tail, identity, specification, mutations, notochord

MeSH Terms

Animals
Fetal Proteins*
Gene Expression Regulation, Developmental*
History, 19th Century
History, 20th Century
Mice
Mutagenesis
Neoplasms/genetics
T-Box Domain Proteins/metabolism*

PubMed

11268043 Full text @ Bioessays

Abstract

In one of the first genetic screens aimed at identifying induced developmental mutants, Nadine Dobrovolska'ia-Zavadskaia, working at the Pasteur Laboratory in the 1920s, isolated and characterized a mutation affecting Brachyury, a gene that regulates tail and axial development in the mouse. Dobrovolskai'a-Zavadskai'a's analysis of Brachyury and other mutations affecting tail development were among the earl lest attempts to link gene action with a tissue-specific developmental process in a vertebrate, Her analyses of genes that interacted with Brachyuryled to the discovery of the t-haplotype chromosome of mouse, After 70 years, Brachyury and the multiple genes with which it interacts continue to occupy a prominent focus in developmental biology research. A goal of this review is to identify the contributions that Dobrovolskai'a-Zavadskaia made to our current th in ki ng about Brachyury and how she helped to shape the dawn of the field of developmental genetics.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Korzh et al., 2001 ZDB-PUB-010718-41 PMID:11268043

Nadine Dobrovolskaia-Zavadskaia and the dawn of developmental genetics

Korzh et al., 2001

ZDB-PUB-010718-41
PMID:11268043