Nadine Dobrovolskaia-Zavadskaia and the dawn of developmental genetics
- Korzh, V. and Grunwald, D.
- BioEssays : news and reviews in molecular, cellular and developmental biology 23(4): 365-371 (Review)
- Registered Authors
- Grunwald, David, Korzh, Vladimir
- T-box genes, mesoderm formation, floor plate, zebrafish, mouse, tail, identity, specification, mutations, notochord
- MeSH Terms
- Fetal Proteins*
- Gene Expression Regulation, Developmental*
- History, 19th Century
- History, 20th Century
- T-Box Domain Proteins/metabolism*
- 11268043 Full text @ Bioessays
Korzh, V. and Grunwald, D. (2001) Nadine Dobrovolskaia-Zavadskaia and the dawn of developmental genetics. BioEssays : news and reviews in molecular, cellular and developmental biology. 23(4):365-371.
In one of the first genetic screens aimed at identifying induced developmental mutants, Nadine Dobrovolska'ia-Zavadskaia, working at the Pasteur Laboratory in the 1920s, isolated and characterized a mutation affecting Brachyury, a gene that regulates tail and axial development in the mouse. Dobrovolskai'a-Zavadskai'a's analysis of Brachyury and other mutations affecting tail development were among the earl lest attempts to link gene action with a tissue-specific developmental process in a vertebrate, Her analyses of genes that interacted with Brachyuryled to the discovery of the t-haplotype chromosome of mouse, After 70 years, Brachyury and the multiple genes with which it interacts continue to occupy a prominent focus in developmental biology research. A goal of this review is to identify the contributions that Dobrovolskai'a-Zavadskaia made to our current th in ki ng about Brachyury and how she helped to shape the dawn of the field of developmental genetics.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes