PUBLICATION
Developmental analysis of ceruloplasmin gene and liver formation in zebrafish
- Authors
- Korzh, S., Emelyanov, A., and Korzh, V.
- ID
- ZDB-PUB-010511-6
- Date
- 2001
- Source
- Mechanisms of Development 103(1-2): 137-139 (Journal)
- Registered Authors
- Korzh, Vladimir
- Keywords
- mutants; flh(-/-); oep(-/-); yolk sac; early hepatic cells
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Ceruloplasmin/biosynthesis*
- Ceruloplasmin/genetics*
- Endoderm/metabolism
- Genetic Markers
- In Situ Hybridization
- Liver/embryology*
- Liver/metabolism*
- Models, Biological
- Mutation
- Time Factors
- Tissue Distribution
- Yolk Sac/metabolism
- Zebrafish
- PubMed
- 11335121 Full text @ Mech. Dev.
Citation
Korzh, S., Emelyanov, A., and Korzh, V. (2001) Developmental analysis of ceruloplasmin gene and liver formation in zebrafish. Mechanisms of Development. 103(1-2):137-139.
Abstract
Formation of the liver in zebrafish has been analyzed during normal embryogenesis using ceruloplasmin (Cp) as a specific marker. The asymmetric expression of Cp has been detected in dorsal endoderm at 16 hpf and later in the early hepatic cells in the yolk sac. The liver primordium can be detected after 32 hpf. In oep(-/-) mutant, which lacks dorsal endoderm, the liver fails to form. In the notochordless flh(-/-) mutant, the asymmetry of the liver has been lost. Therefore the notochord, dorsal endoderm and endoderm of the yolk sac play a role in liver formation in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping