PUBLICATION
Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity
- Authors
- Trainor, P.A. and Krumlauf, R.
- ID
- ZDB-PUB-010404-10
- Date
- 2000
- Source
- Nature reviews. Neuroscience 1(2): 116-124 (Review)
- Registered Authors
- Krumlauf, Robb
- Keywords
- none
- MeSH Terms
-
- Gene Expression Regulation/physiology
- Genes, Homeobox/physiology*
- Body Patterning/physiology*
- Neural Crest/embryology*
- Face/embryology
- Embryonic and Fetal Development/physiology
- Skull/embryology
- Animals
- Rhombencephalon/embryology*
- PubMed
- 11252774 Full text @ Nat Rev Neurosci
Citation
Trainor, P.A. and Krumlauf, R. (2000) Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity. Nature reviews. Neuroscience. 1(2):116-124.
Abstract
Understanding the patterning mechanisms that control head development--particularly the neural crest and its contribution to bones, nerves and connective tissue--is an important problem, as craniofacial anomalies account for one-third of all human congenital defects. Classical models for craniofacial patterning argue that the morphogenic program and Hox gene identity of the neural crest is pre-patterned, carrying positional information acquired in the hindbrain to the peripheral nervous system and the branchial arches. Recently, however, plasticity of Hox gene expression has been observed in the hindbrain and cranial neural crest of chick, mouse and zebrafish embryos. Hence, craniofacial development is not dependent on neural crest prepatterning, but is regulated by a more complex integration of cell and tissue interactions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping