PUBLICATION

Patterning of the zebrafish retina by a wave of sonic hedgehog activity

Authors
Neumann, C.J. and Nüsslein-Volhard, C.
ID
ZDB-PUB-001017-6
Date
2000
Source
Science (New York, N.Y.)   289(5487): 2137-2139 (Journal)
Registered Authors
Neumann, Carl J., Nüsslein-Volhard, Christiane
Keywords
none
MeSH Terms
  • Animals
  • Biological Evolution
  • Body Patterning*
  • Cell Differentiation
  • Embryonic Induction
  • Gene Expression Regulation, Developmental
  • Hedgehog Proteins
  • Mitogen-Activated Protein Kinases/metabolism
  • Proteins/genetics
  • Proteins/metabolism*
  • Retina/cytology
  • Retina/embryology*
  • Retinal Ganglion Cells/cytology
  • Retinal Ganglion Cells/metabolism*
  • Signal Transduction
  • Trans-Activators*
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed
11000118 Full text @ Science
Abstract
The Drosophila retina is patterned by a morphogenetic wave driven by the Hedgehog signaling protein. Hedgehog, secreted by the first neurons, induces neuronal differentiation and hedgehog expression in nearby uncommitted cells, thereby propagating the wave. Evidence is presented here that the zebrafish Hedgehog homolog, Sonic Hedgehog, is also expressed in the first retinal neurons, and that Sonic Hedgehog drives a wave of neurogenesis across the retina, strikingly similar to the wave in Drosophila. The conservation of this patterning mechanism is unexpected, given the highly divergent structures of vertebrate and invertebrate eyes, and supports a common evolutionary origin of the animal visual system.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes