PUBLICATION

Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development

Authors
Yamamoto, A., Kemp, C., Bachiller, D., Geissert, D., and De Robertis, E.M.
ID
ZDB-PUB-000825-4
Date
2000
Source
Genesis (New York, N.Y. : 2000)   27(2): 49-57 (Journal)
Registered Authors
De Robertis, Eddy
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Cadherins/biosynthesis*
  • Cadherins/genetics
  • Embryonic and Fetal Development/genetics
  • Gene Expression Regulation, Developmental
  • Mesoderm/metabolism*
  • Mice
  • Molecular Sequence Data
PubMed
10890978 Full text @ Genesis
Abstract
Summary: Paraxial protocadherin (PAPC) is a cell adhesion molecule that marks cells undergoing convergence-extension cell movements in Xenopus and zebrafish gastrulating embryos. Here a mouse homologue (mpapc) was identified and characterized. During early- to mid-gastrulation, mpapc is expressed in the primitive streak as the trunk mesoderm undergoes morphogenetic cell movements. At head-fold stage mpapc expression becomes localized to paraxial regions in which somites are formed in the segmental plate. At later stages, mpapc displays a complex expression pattern in cerebral cortex, olfactory bulb, inferior colliculus, and in longitudinal stripes in hindbrain. To analyze the effect of the loss of PAPC function during mouse development, a null allele of the mouse papc gene was generated. Homozygous animals show no defects in their skeleton and are viable and fertile.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping