ZFIN ID: ZDB-PUB-000824-34
Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis
Davidson, A.J. and Zon, L.I.
Date: 2000
Source: Current topics in developmental biology   50: 45-60 (Chapter)
Registered Authors: Davidson, Alan, Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning/physiology
  • Embryonic Induction/physiology
  • Genes, Homeobox
  • Hematopoietic Stem Cells/physiology*
  • Mesoderm/physiology*
PubMed: 10948449 Full text @ Curr. Top. Dev. Biol.
The formation of hematopoietic stem cells during development occurs by a multistep process that begins with the induction of ventral mesoderm. This mesoderm is patterned during gastrulation by a bone morphogenetic protein (BMP) signaling pathway that is mediated, at least in part, by members of the Mix and Vent families of homeobox transcription factors. Following gastrulation, a subset of ventral mesoderm is specified to become hematopoietic stem cells. Key determinants of hematopoietic fate include the product of the zebrafish cloche gene and the basic helix-loop-helix transcription factor SCL. Future studies in Xenopus and zebrafish should reveal other critical factors in this developmental pathway.