PUBLICATION

An inherited functional circadian clock in zebrafish embryos

Authors
Delaunay, F., Thisse, C., Marchand, O., Laudet, V., and Thisse, B.
ID
ZDB-PUB-000726-8
Date
2000
Source
Science (New York, N.Y.)   289(5477): 297-300 (Journal)
Registered Authors
Delaunay, Franck, Laudet, Vincent, Marchand, Oriane, Thisse, Bernard, Thisse, Christine
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Circadian Rhythm*/genetics
  • DNA-Binding Proteins*
  • Embryo, Nonmammalian/metabolism
  • Embryonic Development
  • Female
  • Gene Expression Regulation, Developmental
  • Light
  • Molecular Sequence Data
  • Nuclear Proteins/genetics*
  • Nuclear Proteins/physiology
  • Period Circadian Proteins
  • Proteins/genetics
  • Receptors, Cytoplasmic and Nuclear*
  • Transcription Factors
  • Zebrafish/embryology
  • Zebrafish/physiology*
  • Zebrafish Proteins
PubMed
10894777 Full text @ Science
Abstract
Circadian clocks are time-keeping systems found in most organisms. In zebrafish, expression of the clock gene Period3 (Per3) oscillates throughout embryogenesis in the central nervous system and the retina. Per3 rhythmic expression was free-running and was reset by light but not by the developmental delays caused by low temperature. The time of fertilization had no effect on Per3 expression. Per3 messenger RNA accumulates rhythmically in oocytes and persists in embryos. Our results establish that the circadian clock functions during early embryogenesis in zebrafish. Inheritance of maternal clock gene products suggests a mechanism of phase inheritance through ovogenesis.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes