PUBLICATION
Zebrafish: a genetic approach in studying hematopoiesis
- Authors
- Paw, B.H. and Zon, L.I.
- ID
- ZDB-PUB-000309-30
- Date
- 2000
- Source
- Current opinion in hematology 7(2): 79-84 (Review)
- Registered Authors
- Paw, Barry, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Hematopoiesis/genetics
- Hematopoiesis/physiology
- Mutation
- Zebrafish/blood*
- Zebrafish/genetics*
- PubMed
- 10698293 Full text @ Curr. Opin. Hematol.
Citation
Paw, B.H. and Zon, L.I. (2000) Zebrafish: a genetic approach in studying hematopoiesis. Current opinion in hematology. 7(2):79-84.
Abstract
The zebrafish (Danio rerio) has emerged in recent years as an exciting animal model system for studying vertebrate organ development and, in particular, the development of the hematopoietic system. The combined advantages of developmental biology and genetic screens for mutations in zebrafish have provided insights into early events in hematopoiesis and identified several genes required for normal blood development in vertebrates. As a result of the large-scale mutagenesis screens for developmental mutants, several zebrafish mutants with defects in blood development have been recovered. This review discusses how these blood mutations in zebrafish have given new perspectives on hematopoietic development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping