PUBLICATION
Toxicity of cadmium-contaminated clay to the zebrafish Danio rerio
- Authors
- van den Belt, K., Van Puymbroeck, S., and Witters, H.
- ID
- ZDB-PUB-000201-30
- Date
- 2000
- Source
- Archives of environmental contamination and toxicology 38(2): 191-196 (Journal)
- Registered Authors
- Witters, Hilda
- Keywords
- none
- MeSH Terms
-
- Aluminum Silicates/toxicity*
- Animals
- Biological Availability
- Cadmium/pharmacokinetics
- Cadmium/toxicity*
- Ecosystem
- Kaolin/toxicity
- Lethal Dose 50
- Zebrafish
- PubMed
- 10629281 Full text @ Arch. Environ. Contam. Toxicol.
Citation
van den Belt, K., Van Puymbroeck, S., and Witters, H. (2000) Toxicity of cadmium-contaminated clay to the zebrafish Danio rerio. Archives of environmental contamination and toxicology. 38(2):191-196.
Abstract
In this study, the toxicity of cadmium-contaminated clay to the zebrafish Danio rerio was evaluated. Kaolin clay was spiked with CdCl(2) (1.28 mg Cd/g clay) and
adult zebrafish were exposed to 0, 500, 1,000, and 2,000 mg/L Cd-contaminated clay in a continuous recirculation system. Cumulative mortality was evaluated as a function of exposure time, and LT50 values were calculated. Results of acute toxicity tests showed that an exposure to 1,000 mg/L Cd-contaminated clay resulted in LT50 values of 12 and 92 h (n = 2 experiments) and in a LT50 value of 22 h in both experiments with 2,000 mg/L Cd-contaminated clay. Positive control experiments with corresponding measured dissolved Cd concentrations were performed to evaluate by comparison the toxicity of the clay-bound Cd. These control experiments gave LT50 values higher than 144 h for both conditions. Moreover, no toxicity (LT50 > 144 h) of 2,000 mg/L uncontaminated clay was observed. This study showed that cadmium present on clay particles can be bioavailable and exert a toxic effect to the zebrafish D. rerio.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping