ZFIN Person: Lyons, Susan

ZFIN ID: ZDB-PERS-990505-5

ZFIN ID: ZDB-PERS-990505-5

Lyons, Susan

Email:	suslyons@umich.edu
URL:
Affiliation:	Lyons Lab
Address:	1150 West Medical Center Drive Medical Science Building I Box 0612 Room 5315 Ann Arbor, MI 48109-0612 USA
Country:	United States
Phone:	(734) 615-6412
Fax:	(734) 615-7012
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

I am studying myeloid development using the zebrafish model. I am currently isolating ENU-mutagenized fish with defects in the myeloid pathway. As an Oncologist, I have a long-term interest in relating my findings to understanding human leukemia.

PUBLICATIONS

Su, F., Juarez, M.A., Cooke, C.L., LaPointe, L., Shavit, J.A., Yamaoka, J.S., and Lyons, S.E. (2007) Differential Regulation of Primitive Myelopoiesis in the Zebrafish by Spi-1/Pu.1 and C/ebp1. Zebrafish. 4(3):187-199

Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13996-140001

Raeker, M.O., Su, F., Geisler, S.B., Borisov, A.B., Kontrogianni-Konstantopoulos, A., Lyons, S.E., and Russell, M.W. (2006) Obscurin is required for the lateral alignment of striated myofibrils in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(8):2018-2029

Juarez, M.A., Su, F., Chun, S., Kiel, M.J., and Lyons, S.E. (2005) Distinct roles for Scl in erythroid specification and maturation in zebrafish. The Journal of biological chemistry. 280(50):41636-41644

Nishikawa, K., Kobayashi, M., Masumi, A., Lyons, S.E., Weinstein, B.M.,Liu, P.P., and Yamamoto, M. (2003) Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Molecular and cellular biology. 23(22):8295-8305

Lyons, S.E., Lawson, N.D., Lei, L., Bennett, P.E., Weinstein, B.M., and Liu, P.P. (2002) A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proceedings of the National Academy of Sciences of the United States of America. 99(8):5454-5459

Lyons, S.E., Shue, B.C., Lei, L., Oates, A.C., Zon, L.I., and Liu, P.P. (2001) Molecular cloning, genetic mapping, and expression analysis of four zebrafish c/ebp genes. Gene. 281(1-2):43-51

Lyons, S.E., Shue, B.C., Oates, A.C., Zon, L.I., and Liu, P.P. (2001) A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain. Blood. 97(9):2611-2617

Lyons, S.E., Shue, B.C., Oates, A.C., Zon, L.I., and Liu, P.P. (2000) A novel myeloid-restricted zebrafish C/EBP with a potent transcriptional activation domain. Blood. 96(11):2877

Lyons, S.E., Lawson, N.D., Bennett, P.J., Weinstein, B.M., and Liu, P.P. (2000) Nonsense mutation in gata1 identified in the "bloodless" zebrafish vlad tepes. Blood. 96(11):2400

NON-ZEBRAFISH PUBLICATIONS
1. Stimac, E., Lyons, S. and Pious, D. Transcription of HLA class II genes in the absence of B- cell-specific octamer binding factor. Mol Cell Biol 8:3734-3739, 1988.

2. Nichols, W.C., Lyons, S.E., Harrison, J.S., Cody, R.L. and Ginsburg, D. Severe von Willebrand disease due to a defect at the level of von Willebrand factor mRNA expression: Detection by exonic PCR-restriction fragment length polymorphism analysis. Proc Natl Acad Sci USA 88:3857-3861, 1991.

3. Lyons, S.E., Bruck, M.E., Bowie, E.J.W., and Ginsburg, D. Impaired intracellular transport produced by a subset of type IIA von Willebrand disease mutations. J Biol Chem 267:4424-4430, 1992.

4. Cooney, K.A., Lyons, S.E., and Ginsburg, D. Functional analysis of a type IIB von Willebrand disease missense mutation: Increased binding of large von Willebrand factor multimers to platelets. Proc Natl Acad Sci USA 89:2869-2872, 1992.

5. Lyons, S.E. and Ginsburg, D. Molecular and cellular biology of von Willebrand factor. Trends in Cardiovascular Medicine 4:34-39, 1994.

6. Lyons, S.E., Cooney, K.A., Bockenstedt, P., and Ginsburg, D. Characterization of Leu777Pro and Ile865Thr type IIA von Willebrand disease mutations. Blood 83:1551- 1557, 1994.

7. Lyons, S.E. and Liebowitz, D. The roles of human viruses in the pathogenesis of lymphoma. Semin Oncol. 25(4):461-75, 1998.