ZFIN ID: ZDB-PERS-990302-33
Lorent, Kristin
Email: lorentk@mail.med.upenn.edu
URL:
Affiliation: Pack Lab
Address: Department of Medicine University of Pennsylvania School of Medicine 1230 Biomedical Research Building II/III 421 Curie Boulevard Philadelphia, PA 19104 USA
Country: United States
Phone: (215) 573-7562
Fax: (215) 573-7149
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Ye, S., Liu, Y., Fuller, A.M., Katti, R., Ciotti, G.E., Chor, S., Alam, M.Z., Devalaraja, S., Lorent, K., Weber, K., Haldar, M., Pack, M.A., Eisinger-Mathason, T.S.K. (2020) TGFβ and Hippo pathways cooperate to enhance sarcomagenesis and metastasis through the hyaluronan mediated motility receptor (HMMR). Molecular cancer research : MCR. 18(4):560-573
Zhao, X., Lorent, K., Wilkins, B., Marchione, D.M., Gillespie, K., Waisbourd-Zinman, O., So, J., Koo, K.A., Shin, D., Porter, J.R., Wells, R.G., Blair, I., Pack, M. (2016) Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology (Baltimore, Md.). 64(3):894-907
Koo, K.A., Lorent, K., Gong, W., Windsor, P., Whittaker, S.J., Pack, M., Wells, R., Porter, J.R. (2015) Biliatresone, A Reactive Natural Toxin from Dysphania glomulifera and D. littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone. Chemical Research in Toxicology. 28(8):1519-21
Lorent, K., Gong, W., Koo, K.A., Waisbourd-Zinman, O., Karjoo, S., Zhao, X., Sealy, I., Kettleborough, R.N., Stemple, D.L., Windsor, P.A., Whittaker, S.J., Porter, J.R., Wells, R.G., Pack, M. (2015) Identification of a plant isoflavonoid that causes biliary atresia. Science Translational Medicine. 7:286ra67
Wilkins, B.J., Lorent, K., Matthews, R.P., and Pack, M. (2013) p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis. PLoS One. 8(10):e77670
Gyda, M., Wolman, M., Lorent, K., and Granato, M. (2012) The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish. PLoS Genetics. 8(11):e1003106
Matthews, R.P., Eauclaire, S.F., Mugnier, M., Lorent, K., Cui, S., Ross, M.M., Zhang, Z., Russo, P., and Pack, M. (2011) DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia. Hepatology (Baltimore, Md.). 53(3):905-914
Lorent, K., Moore, J.C., Siekmann, A.F., Lawson, N., and Pack, M. (2010) Reiterative use of the notch signal during zebrafish intrahepatic biliary development. Developmental dynamics : an official publication of the American Association of Anatomists. 239(3):855-864
Matthews, R.P., Lorent, K., MaƱoral-Mobias, R., Huang, Y., Gong, W., Murray, I.V., Blair, I.A., and Pack, M. (2009) TNF{alpha}-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase. Development (Cambridge, England). 136(5):865-875
Davuluri, G., Gong, W., Yusuff, S., Lorent, K., Muthumani, M., Dolan, A.C., and Pack, M. (2008) Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genetics. 4(10):e1000240
Matthews, R.P., Lorent, K., and Pack, M. (2008) Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(1):124-131
Ho, S.Y., Lorent, K., Pack, M., and Farber, S.A. (2006) Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure. Cell Metabolism. 3(4):289-300
Matthews, R.P., Plumb-Rudewiez, N., Lorent, K., Gissen, P., Johnson, C.A., Lemaigre, F., and Pack, M. (2005) Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6. Development (Cambridge, England). 132(23):5295-5306
Yee, N.S., Lorent, K., and Pack, M. (2005) Exocrine pancreas development in zebrafish. Developmental Biology. 284(1):84-101
Wallace, K.N., Akhter, S., Smith, E.M., Lorent, K., and Pack, M. (2005) Intestinal growth and differentiation in zebrafish. Mechanisms of Development. 122(2):157-73
Lorent, K., Yeo, S.Y., Oda, T., Chandrasekharappa, S., Chitnis, A., Matthews, R.P., and Pack, M. (2004) Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy. Development (Cambridge, England). 131(22):5753-5766
Matthews, R.P., Lorent, K., Russo, P., and Pack, M. (2004) The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development. Developmental Biology. 274(2):245-259
Lorent, K., Liu, K.S., Fetcho, J.R., and Granato, M. (2001) The zebrafish space cadet gene controls axonal pathfinding of neurons that modulate fast turning movements. Development (Cambridge, England). 128(11):2131-2142

NON-ZEBRAFISH PUBLICATIONS