ZFIN ID: ZDB-PERS-970505-38
Feldman, Benjamin
Email: bfeldman@mail.nih.gov
URL: http://zcore.nichd.nih.gov
Affiliation: Feldman Lab
Address: Director, NICHD Zebrafish Core Program on Genomics of Differentiation Eunice Kennedy Shriver National Institute of Child Health & Human Development National Institutes of Health, DHHS Building 6, Room B140 6 Center Drive, MSC 2759 Bethesda, MD 20892 USA
Country: United States
Phone: 301-443-5556
ORCID ID: 0000-0003-4838-8641


Gastrulation, germ layer formation and disease models.


Ph.D., Columbia University. Cellular, Molecular and Biophysical Studies. 'A Genetic Analysis of Murine Fibroblast Growth Factor Four.' 1995

Bachelor of Arts, University of California at Berkeley. Microbiology and Immunology. 1985

Tseng, W.C., Johnson Escauriza, A.J., Tsai-Morris, C.H., Feldman, B., Dale, R.K., Wassif, C.A., Porter, F.D. (2021) The role of Niemann-Pick type C2 in zebrafish embryonic development. Development (Cambridge, England). 148(7):
Trivellin, G., Tirosh, A., Hernández-Ramírez, L.C., Gupta, T., Tsai-Morris, C.H., Faucz, F.R., Burgess, H.A., Feldman, B., Stratakis, C.A. (2020) The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish. Molecular and Cellular Endocrinology. 520:111091
Tseng, W.C., Loeb, H.E., Pei, W., Tsai-Morris, C.H., Xu, L., Cluzeau, C.V., Wassif, C.A., Feldman, B., Burgess, S.M., Pavan, W.J., Porter, F.D. (2018) Modeling Niemann-Pick disease type C1 in zebrafish: a robust platform for in vivo screening of candidate therapeutic compounds.. Disease models & mechanisms. 11(9)
Trivellin, G., Bjelobaba, I., Daly, A.F., Larco, D.O., Palmeira, L., Faucz, F.R., Thiry, A., Leal, L.F., Rostomyan, L., Quezado, M., Schernthaner-Reiter, M.H., Janjic, M., Villa, C., Wu, T.J., Stojilkovic, S.S., Albert, B., Feldman, B., Stratakis, C.A. (2016) Characterization of GPR101 transcripts structure and expression patterns. Journal of molecular endocrinology. 57(2):97-111
Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813
Horstick, E.J., Jordan, D.C., Bergeron, S.A., Tabor, K.M., Serpe, M., Feldman, B., Burgess, H.A. (2015) Increased functional protein expression using nucleotide sequence features enriched in highly expressed genes in zebrafish. Nucleic acids research. 43(7):e48
Feldman, B., Tuchman, M., Caldovic, L. (2014) A zebrafish model of hyperammonemia. Molecular genetics and metabolism. 113(1-2):142-7
Hong, S.K., Jang, M.K., Brown, J.L., McBride, A.A., and Feldman, B. (2011) Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2. Development (Cambridge, England). 138(4):787-795
Pei, W., Kratz, L.E., Bernardini, I., Sood, R., Yokogawa, T., Dorward, H., Ciccone, C., Kelley, R.I., Anikster, Y., Burgess, H.A., Huizing, M., and Feldman, B. (2010) A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3. Development (Cambridge, England). 137(15):2587-2596
Hong, S.K., Levin, C.S., Brown, J.L., Wan, H., Sherman, B.T., Huang, D.W., Lempicki, R.A., and Feldman, B. (2010) Pre-gastrula expression of zebrafish extraembryonic genes. BMC Developmental Biology. 10:42
Pei, W., and Feldman, B. (2009) Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Developmental Biology. 326(1):201-211
Domené, S., Roessler, E., El-Jaick, K.B., Snir, M., Brown, J.L., Vélez, J.I., Bale, S., Lacbawan, F., Muenke, M., and Feldman, B. (2008) Mutations in the human SIX3 gene in holoprosencephaly are loss-of-function. Human molecular genetics. 17(24):3919-3928
Brown, J.L., Snir, M., Noushmehr, H., Kirby, M., Hong, S.K., Elkahloun, A.G., and Feldman, B. (2008) Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification. Proceedings of the National Academy of Sciences of the United States of America. 105(34):12337-12342
Schröter, C., Herrgen, L., Cardona, A., Brouhard, G.J., Feldman, B., and Oates, A.C. (2008) Dynamics of zebrafish somitogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 237(3):545-553
Pei, W., Noushmehr, H., Costa, J., Ouspenskaia, M.V., Elkahloun, A.G., and Feldman, B. (2007) An early requirement for maternal FoxH1 during zebrafish gastrulation. Developmental Biology. 310(1):10-22
Pei, W., Williams, P.H., Clark, M.D., Stemple, D.L., and Feldman, B. (2007) Environmental and genetic modifiers of squint penetrance during zebrafish embryogenesis. Developmental Biology. 308(2):368-378
Feldman, B., Concha, M.L., Saude, L., Parsons, M.J., Adams, R.J., Wilson, S.W., and Stemple, D.L. (2002) Lefty antagonism of squint is essential for normal gastrulation. Current biology : CB. 12(24):2129-2135
Parsons, M.J., Pollard, S.M., Saude, L., Feldman, B., Coutinho, P., Hirst, E.M., and Stemple, D.L. (2002) Zebrafish mutants identify an essential role for laminins in notochord formation. Development (Cambridge, England). 129(13):3137-3146
Feldman, B. and Stemple, D.L. (2001) Morpholino phenocopies of sqt, oep, and ntl mutations. Genesis (New York, N.Y. : 2000). 30(3):175-177
Feldman, B. (2001) The Second European Conference on Zebrafish Genetics and Development. Comparative and functional genomics. 2(4):252-256
Feldman, B., Dougan, S.T., Schier, A.F., and Talbot, W.S. (2000) Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish. Current biology : CB. 10(9):531-534
Imai, Y., Feldman, B., Schier, A.F., and Talbot, W.S. (2000) Analysis of chromosomal rearrangements induced by postmeiotic mutagenesis with ethylnitrosourea in zebrafish. Genetics. 155(1):261-272
Feldman, B., Gates, M.A., Egan, E.S., Dougan, S.T., Rennebeck, G., Sirotkin, H.I., Schier, A.F., and Talbot, W.S. (1998) Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature. 395:181-185

JS Colvin, B Feldman, JH Nadeau, M Goldfarb and DM Ornitz (1999). enomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Developmental Dynamics, 216:72-88

H. Hartung , B. Feldman, F. Lovec, D. Coulier, D. Birnbaum, and M. Goldfarb (1997). Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart. Mechanisms of Development, 64(1-2):31-39

B. Feldman, W.T. Poueymirou, V. E. Papaioannou, T. DeChiara and M. Goldfarb (1995). Requirement of FGF-4 for post-implantation murine development. Science, 267: 246-249

R. Foisner, B. Feldman, L. Sander, G. Seifert, U. Artlieb, and G. Wiche (1994). A panel of monoclonal antibodies to rat plectin: distinction by epitope mapping and immunoreactivity with different tissues and cell lines. Acta Histochem 96(4):421-438

R. Foisner, B. Feldman, L. Sander, and G. Wiche (1991). Monoclonal Antibody Mapping of Structural and Functional Plectin Epitopes. Journal of Cell Biology, 112, 397-405

R. Foisner, B. Feldman and G. Wiche (1988). Partial Proteolysis of Plectin and Localization of Self-Interaction and Vimentin Binding Sites on Separate Molecular Domains. Protoplasma 145, 120-128