ZFIN Person: Peng, Chun

ZFIN ID: ZDB-PERS-970217-12

ZFIN ID: ZDB-PERS-970217-12

Peng, Chun

Email:	cpeng@yorku.ca
URL:
Affiliation:
Address:	Department of Biology York University 4700 Keele Street Toronto, Ontario, M3J 1P3 Canada
Country:
Phone:	(416) 736-2100 ext. 40558
Fax:	(416) 736-5698
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Research in my laboratory is directed towards understanding how hormones and growth factors regulate reproductive functions in vertebrates, especially in fish and human. We are particularly interested in 1) physiological roles of hormones and growth factors in female reproduction and 2) molecular mechanisms by which hormones and growth factors regulate reproductive functions.

Using zebrafish as a model, we have been investigating the role of activin, TGF-beta and BMP-15 in the ovary. We have cloned cDNAs for activin subunits, activin receptors, TGF-beta and TGF-beta receptors. We have also demonstrated that activin-A stimulates while TGF-beta1 inhibits oocyte maturation. We are currently determining how activin and TGF-beta are involved in the regulation of oocyte maturation by examining their effects on the receptors for gonadotropins and maturation inducing hormone and on steroid hormone production. The role of BMP-15 in follicle development and maturation is also under investigation.

PUBLICATIONS

Zayed, Y., Malik, R., Qi, X., Peng, C. (2020) Nodal regulates ovarian functions in zebrafish. Molecular and Cellular Endocrinology. 511:110821

Zayed, Y., Qi, X., Peng, C. (2019) Identification of Novel MicroRNAs and Characterization of MicroRNA Expression Profiles in Zebrafish Ovarian Follicular Cells. Frontiers in endocrinology. 10:518

Perez, C.J., Tata, A., de Campos, M.L., Peng, C., Ifa, D.R. (2017) Monitoring Toxic Ionic Liquids in Zebrafish (Danio rerio) with Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI). Journal of the American Society for Mass Spectrometry. 28(6):1136-1148

Qi, X., Salem, M., Zhou, W., Sato-Shimizu, M., Ye, G., Smitz, J., Peng, C. (2016) Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production. Endocrinology. 157:3355-65

Abramov, R., Fu, G., Zhang, Y., and Peng, C. (2013) Expression and regulation of miR-17a and miR-430b in zebrafish ovarian follicles. General and comparative endocrinology. 188:309-15

Shepperd, E., Peng, C., and Unniappan, S. (2012) Ghrelinergic system in fish ovaries and ghrelin inhibition of germinal vesicle breakdown in zebrafish oocytes. General and comparative endocrinology. 176(3):426-431

Carnevali, O., Tosti, L., Speciale, C., Peng, C., Zhu, Y., and Maradonna, F. (2010) DEHP Impairs Zebrafish Reproduction by Affecting Critical Factors in Oogenesis. PLoS One. 5(4):e10201

Clelland, E., and Peng, C. (2009) Endocrine/Paracrine Control of Zebrafish Ovarian Development. Molecular and Cellular Endocrinology. 312(1-2):42-52

Peng, C., Clelland, E., and Tan, Q. (2009) Potential role of bone morphogenetic protein-15 in zebrafish follicle development and oocyte maturation. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 153(1):83-87

Tan, Q., Balofsky, A., Weisz, K., and Peng, C. (2009) Role of activin, transforming growth factor-beta and bone morphogenetic protein 15 in regulating zebrafish oocyte maturation. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 153(1):18-23

Clelland, E.S., Tan, Q., Balofsky, A., Lacivita, R., and Peng, C. (2007) Inhibition of premature oocyte maturation: A role for Bone Morphogenetic Protein 15 in zebrafish ovarian follicles. Endocrinology. 148(11):5451-5458

Clelland, E., Kohli, G., Campbell, R.K., Sharma, S., Shimasaki, S., and Peng, C. (2006) Bone morphogenetic protein 15 in the zebrafish ovary: cDNA cloning, genomic organization, tissue distribution and role in oocyte maturation. Endocrinology. 147(1):201-209

Kohli, G., Clelland, E., and Peng, C. (2005) Potential targets of transforming growth factor-beta1 during inhibition of oocyte maturation in zebrafish. Reproductive Biology and Endocrinolgy. 3:53

Dimuccio, T., Mukai, S.T., Clelland, E., Kohli, G., Cuartero, M., Wu, T., and Peng, C. (2005) Cloning of a second form of activin-betaA cDNA and regulation of activin-betaA subunits and activin type II receptor mRNA expression by gonadotropin in the zebrafish ovary. General and comparative endocrinology. 143(3):287-299

Kohli, G., Hu, S., Clelland, E., Di Muccio, T., Rothenstein, J., and Peng, C. (2003) Cloning of transforming growth factor-beta1 (TGF-beta1) and its type II receptor from zebrafish ovary and role of TGF-beta1 in oocyte maturation. Endocrinology. 144(5):1931-1941

Wu, T.T., Patel, H., Mukai, S., Melino, C., Garg, R., Ni, X.Y., Chang, J.B., and Peng, C. (2000) Activin, inhibin, and follistatin in zebrafish ovary: expression and role in oocyte maturation. Biology of reproduction. 62(6):1585-1592

Garg, R.R., Bally-Cuif, L., Lee, S.E., Gong, Z., Ni, X., Hew, C.L., and Peng, C. (1999) Cloning of zebrafish activin type IIB receptor (ActRIIB) cDNA and mRNA expression of ActRIIB in embryos and adult tissues. Molecular and Cellular Endocrinology. 153(1-2):169-181

NON-ZEBRAFISH PUBLICATIONS
Selected Publications since 2000
Peng C. 2003. The transforming growth factor-beta superfamily and its role in human ovary and placenta. Can J Obs Gyn, in press.

Chen VT, Peng C, Leung PC, 2003. Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells. Reprod Biol Endocrinol. 24:29-36.

Roberts H, Hu S, Qiu Q, Leung PCK, Caniggia I, Gruslin A, Tsang B, and Peng C, 2003. Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its Ligand, Nodal, in human placenta. Biol Reprod, 68: 1719-1726.

Luo S, Yu H, Wu D, and Peng C, 2002. Transforming growth factor- inhibits steroidogenesis in human trophoblast cells. Mol Human Reprod 8: 318-325.

Wu D, Luo S, Wang Y, Zhuang L, Chen Y and Peng C, 2001. Smads in human trophoblast cells: Expression, regulation and role in transforming growth factor-beta1-induced transcriptional activity. Mol Cell Endocrinol 175: 111-121.

Ni X, Luo S, Minegishi T and Peng C, 2000. Activin-A in JEG-3 cells: Potential role as an autocrine regulator of steriodogenesis. Biol Reprod, 62: 1224-1230.

Peng C and Mukai S, 2000. Activins and their receptors in female reproduction. Biochem Cell Biol 78:261-279