ZFIN Person: Schartl, Manfred

ZFIN ID: ZDB-PERS-960805-498

ZFIN ID: ZDB-PERS-960805-498

Schartl, Manfred

Email:	phch1@biozentrum.uni-wuerzburg.de
URL:	http://www.pch1.biozentrum.uni-wuerzburg.de/
Affiliation:	Schartl Lab
Address:	Physiologische Chemie I Biozentrum der Universitaet Wuerzburg Am Hubland Wuerzburg, D-97074 Germany
Country:	Germany
Phone:	0049-931-31-84148
Fax:	0049-931-31-84150
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Biography
Diploma/PhD University of Giessen/Germany
Postdoc/Habilitation Ludwig-Maximilian-University, Munich/Germany
Group leader Max-Planck-Institute for Biochemistry, Martinsried/Germany
Full Professor University of Würzburg

Research Interests:
My main research interests are the molecular processes in organismic development and their malfunction in cancerogenesis. One major topic is the understanding of signal transduction and gene regulation in melanoma. We use the classical Xiphophorus model system and transgenic medaka that develop different types of pigment cell tumors. A second major interest is in the molecular basis and evolution of sex determination. Further interests are in the processes that control differentiation and stemness of embryonic stem cells and their relation to cancer stem cells.

PUBLICATIONS

Biscotti, M.A., Carducci, F., Barucca, M., Gerdol, M., Pallavicini, A., Schartl, M., Canapa, A., Adolfi, M.C. (2020) The transcriptome of the newt Cynops orientalis provides new insights into evolution and function of sexual gene networks in sarcopterygians. Scientific Reports. 10:5445

Anelli, V., Ordas, A., Kneitz, S., Sagredo, L.M., Gourain, V., Schartl, M., Meijer, A.H., Mione, M. (2018) Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. Frontiers in genetics. 9:675

Yu, T., Graf, M., Renn, J., Schartl, M., Larionova, D., Huysseune, A., Witten, P.E., Winkler, C. (2017) A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka. Development (Cambridge, England). 144:265-271

Regneri, J., Klotz, B., Schartl, M. (2016) Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models. Advances in genetics. 95:31-63

Schartl, M., Walter, R.B. (2016) Xiphophorus and Medaka Cancer Models. Advances in experimental medicine and biology. 916:531-52

Wilson, C.A., High, S.K., McCluskey, B.M., Amores, A., Yan, Y.L., Titus, T.A., Anderson, J.L., Batzel, P., Carvan, M.J., Schartl, M., Postlethwait, J.H. (2014) Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains. Genetics. 198(3):1291-308

Hong, N., Schartl, M., Hong, Y. (2014) Derivation of stable zebrafish ES-like cells in feeder-free culture. Cell and tissue research. 357(3):623-32

Amores, A., Catchen, J., Nanda, I., Warren, W., Walter, R., Schartl, M., Postlethwait, J.H. (2014) A RAD-tag Genetic Map for the Platyfish (Xiphophorus maculatus) Reveals Mechanisms of Karyotype Evolution Among Teleost Fish. Genetics. 197(2):625-41

Tomaszkiewicz, M., Chalopin, D., Schartl, M., Galiana, D., Volff, J.N. (2014) A multicopy Y-chromosomal SGNH hydrolase gene expressed in the testis of the platyfish has been captured and mobilized by a Helitron transposon. BMC Genetics. 15:44

Schartl, M. (2014) Beyond the zebrafish: diverse fish species for modeling human disease. Disease models & mechanisms. 7(2):181-92

Schartl, M., Walter, R.B., Shen, Y., Garcia, T., Catchen, J., Amores, A., Braasch, I., Chalopin, D., Volff, J.N., Lesch, K.P., Bisazza, A., Minx, P., Hillier, L., Wilson, R.K., Fuerstenberg, S., Boore, J., Searle, S., Postlethwait, J.H., and Warren, W.C. (2013) The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits. Nature Genetics. 45(5):567-572

Amemiya, C.T., Alfoldi, J., Lee, A.P., Fan, S., Philippe, H., MacCallum, I., Braasch, I., Manousaki, T., Schneider, I., Rohner, N., Organ, C., Chalopin, D., Smith, J.J., Robinson, M., Dorrington, R.A., Gerdol, M., Aken, B., Biscotti, M.A., Barucca, M., Baurain, D., Berlin, A.M., Blatch, G.L., Buonocore, F., Burmester, T., Campbell, M.S., Canapa, A., Cannon, J.P., Christoffels, A., de Moro, G., Edkins, A.L., Fan, L., Fausto, A.M., Feiner, N., Forconi, M., Gamieldien, J., Gnerre, S., Gnirke, A., Goldstone, J.V., Haerty, W., Hahn, M.E., Hesse, U., Hoffmann, S., Johnson, J., Karchner, S.I., Karaku, S., Lara, M., Levin, J.Z., Litman, G.W., Mauceli, E., Miyake, T., Mueller, M.G., Nelson, D.R., Nitsche, A., Olmo, E., Ota, T., Pallavicini, A., Panji, S., Picone, B., Ponting, C.P., Prohaska, S.J., Przybylski, D., Saha, N.R., Ravi, V., Ribeiro, F.J., Sauka-Spengler, T., Scapigliati, G., Searle, S.M.J., Sharpe, T., Simakov, O., Stadler, P.F., Stegeman, J.J., Sumiyama, K., Tabbaa, D., Tafer, H., Turner-Maier, J., van Heusden, P., White, S., Williams, L., Yandell, M., Brinkmann, H., Volff, J.N., Tabin, C.J., Shubin, N., Schartl, M., Jaffe, D.B., Postlethwait, J.H., Venkatesh, B., Palma, F.D., Lander, E.S., Meyer, A., and Lindblad-Toh, K. (2013) The African coelacanth genome provides insights into tetrapod evolution. Nature. 496:311-316

Li, Z., Huang, X., Zhan, H., Zeng, Z., Li, C., Spitsbergen, J.M., Meierjohann, S., Schartl, M., and Gong, Z. (2012) Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish. Journal of hepatology. 56(2):419-425

Schartl, M., Kneitz, S., Wilde, B., Wagner, T., Henkel, C.V., Spaink, H.P., and Meierjohann, S. (2012) Conserved Expression Signatures between Medaka and Human Pigment Cell Tumors. PLoS One. 7(5):e37880

He, X., Yan, Y.L., Eberhart, J.K., Herpin, A., Wagner, T.U., Schartl, M., and Postlethwait, J.H. (2011) miR-196 regulates axial patterning and pectoral appendage initiation. Developmental Biology. 357(2):463-77

McFarlane, L., Svingen, T., Braasch, I., Koopman, P., Schartl, M., and Wilhelm, D. (2011) Expansion of the Ago gene family in the teleost clade. Development genes and evolution. 221(2):95-204

Liedtke, D., Erhard, I., and Schartl, M. (2011) snail gene expression in the medaka, Oryzias latipes. Gene expression patterns : GEP. 11(3-4):181-189

Patton, E.E., Mathers, M.E., and Schartl, M. (2011) Generating and analyzing fish models of melanoma. Methods in cell biology. 105:339-366

Hong, N., Li, M., Zeng, Z., Yi, M., Deng, J., Gui, J., Winkler, C., Schartl, M., and Hong, Y. (2010) Accessibility of host cell lineages to medaka stem cells depends on genetic background and irradiation of recipient embryos. Cellular and molecular life sciences : CMLS. 67(7):1189-1202

Herpin, A., Braasch, I., Kraeussling, M., Schmidt, C., Thoma, E.C., Nakamura, S., Tanaka, M., and Schartl, M. (2010) Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements. PLoS Genetics. 6(2):e1000844

Laisney, J.A., Braasch, I., Walter, R.B., Meierjohann, S., and Schartl, M. (2010) Lineage-specific co-evolution of the Egf receptor/ligand signaling system. BMC Evolutionary Biology. 10:27

Braasch, I., Liedtke, D., Volff, J.N., and Schartl, M. (2009) Pigmentary function and evolution of tyrp1 gene duplicates in fish. Pigment cell & melanoma research. 22(6):839-850

Braasch, I., Brunet, F., Volff, J.N., and Schartl, M. (2009) Pigmentation pathway evolution after whole-genome duplication in fish. Genome biology and evolution. 1:479-493

Pala, I., Schartl, M., Thorsteinsdóttir, S., and Coelho, M.M. (2009) Sex determination in the Squalius alburnoides complex: an initial characterization of sex cascade elements in the context of a hybrid polyploid genome. PLoS One. 4(7):e6401

Herpin, A., Nakamura, S., Wagner, T.U., Tanaka, M., and Schartl, M. (2009) A highly conserved cis-regulatory motif directs differential gonadal synexpression of Dmrt1 transcripts during gonad development. Nucleic acids research. 37(5):1510-1520

Braasch, I., Volff, J.N., and Schartl, M. (2009) The endothelin system: evolution of vertebrate-specific ligand-receptor interactions by three rounds of genome duplication. Mol. Biol. Evol.. 26(4):783-799

Reichwald, K., Lauber, C., Nanda, I., Kirschner, J., Hartmann, N., Schories, S., Gausmann, U., Taudien, S., Schilhabel, M.B., Szafranski, K., Glockner, G., Schmid, M., Cellerino, A., Schartl, M., Englert, C., and Platzer, M. (2009) High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research. Genome biology. 10(2):R16

Klüver, N., Herpin, A., Braasch, I., Driessle, J., and Schartl, M. (2009) Regulatory back-up circuit of medaka Wt1 co-orthologs ensures PGC maintenance. Developmental Biology. 325(1):179-188

Braasch, I., Volff, J.N., and Schartl, M. (2008) The evolution of teleost pigmentation and the fish-specific genome duplication. Journal of Fish Biology. 73(8):1891-1918

Herpin, A., Fischer, P., Liedtke, D., Kluever, N., Neuner, C., Raz, E., and Schartl, M. (2008) Sequential SDF1a and b-induced mobility guides Medaka PGC migration. Developmental Biology. 320(2):319-327

Pala, I., Klüver, N., Thorsteinsdóttir, S., Schartl, M., and Coelho, M.M. (2008) Expression pattern of anti-Müllerian hormone (amh) in the hybrid fish complex of Squalius alburnoides. Gene. 410(2):249-258

Selz, Y., Braasch, I., Hoffmann, C., Schmidt, C., Schultheis, C., Schartl, M., and Volff, J.N. (2007) Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor. Gene. 401(1-2):114-122

Braasch, I., Schartl, M., and Volff, J.N. (2007) Evolution of pigment synthesis pathways by gene and genome duplication in fish. BMC Evolutionary Biology. 7(1):74

Herpin, A., Rohr, S., Riedel, D., Kluever, N., Raz, E., and Schartl, M. (2007) Specification of primordial germ cells in medaka (Oryzias latipes). BMC Developmental Biology. 7:3

Volff, J.N., Nanda, I., Schmid, M., and Schartl, M. (2007) Governing sex determination in fish: regulatory putsches and ephemeral dictators. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 1(2):85-99

Sasaki, T., Shimizu, A., Ishikawa, S.K., Imai, S., Asakawa, S., Murayama, Y., Khorasani, M.Z., Mitani, H., Furutani-Seiki, M., Kondoh, H., Nanda, I., Schmid, M., Schartl, M., Nonaka, M., Takeda, H., Hori, H., Himmelbauer, H., Shima, A., and Shimizu, N. (2007) The DNA sequence of medaka chromosome LG22. Genomics. 89(1):124-133

Klüver, N., Pfennig, F., Pala, I., Storch, K., Schlieder, M., Froschauer, A., Gutzeit, H.O., and Schartl, M. (2007) Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(1):271-281

Renn, J., Winkler, C., Schartl, M., Fischer, R., and Goerlich, R. (2006) Zebrafish and medaka as models for bone research including implications regarding space-related issues. Protoplasma. 229(2-4):209-214

Renn, J., Schaedel, M., Volff, J.N., Goerlich, R., Schartl, M., and Winkler, C. (2006) Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes). Gene. 372:208-218

Bollig, F., Mehringer, R., Perner, B., Hartung, C., Schafer, M., Schartl, M., Volff, J.N., Winkler, C., and Englert, C. (2006) Identification and comparative expression analysis of a second wt1 gene in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(2):554-561

Kluver, N., Kondo, M., Herpin, A., Mitani, H., and Schartl, M. (2005) Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization. Development genes and evolution. 215(6):297-305

Schäfer, M., Rembold, M., Wittbrodt, J., Schartl, M., and Winkler, C. (2005) Medial floor plate formation in zebrafish consists of two phases and requires trunk-derived Midkine-a. Genes & Development. 19(8):897-902

Schäfer, M., Kinzel, D., Neuner, C., Schartl, M., Volff, J.N., and Winkler, C. (2005) Hedgehog and retinoid signalling confines nkx2.2b expression to the lateral floor plate of the zebrafish trunk. Mechanisms of Development. 122(1):43-56

Winkler, C., Schäfer, M., Duschl, J., Schartl, M., and Volff, J.-N. (2003) Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication. Genome research. 13:1067-1081

Altschmied, J., Delfgaauw, J., Wilde, B., Duschl, J., Bouneau, L., Volff, J.-N., and Schartl, M. (2002) Subfunctionalization of duplicate mitf genes associated with differential degeneration of alternative exons in fish. Genetics. 161(1):259-267

Nanda, I., Haaf, T., Schartl, M., Schmid, M., and Burt, D.W. (2002) Comparative mapping of Z-orthologous genes in vertebrates: implications for the evolution of avian sex chromosomes. Cytogenetic and genome research. 99(1-4):178-184

Volff, J.N., Korting, C., Altschmied, J., Duschl, J., Sweeney, K., Wichert, K., Froschauer, A., and Schartl, M. (2001) Jule from the fish Xiphophorus is the first complete vertebrate Ty3/Gypsy retrotransposon from the Mag family. Mol. Biol. Evol.. 18(2):101-111

Götz, R., Köster, R.W., Winkler, C., Raulf, F., Lottspeich, F., Schartl, M., and Thoenen, H. (1994) Neurotrophin-6 is a new member of the nerve growth factor family. Nature. 372(6503):266-269

NON-ZEBRAFISH PUBLICATIONS
Teutschbein, J., Haydn, J.M., Samans, B., Krause, M., Eilers, M., Schartl, M. and Meierjohann, S.: Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins. BMC Cancer 10 (2010) 386.

Meyer, M.K., Schories, S. and Schartl, M.: Description of Gambusia zarskei sp. n. – a new poeciliid fish from the upper Rio Conchos system, Chihuahua, Mexico (Teleostei: Cyprinodontiformes: Poeciliidae). Vertebrate Zoology 60 (2010) 11-18.

Meierjohann, S., Hufnagel, A., Wende, E., Kleinschmidt, M.A., Wolf, K., Friedl, P., Gaubatz, S. and Schartl, M.: MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9 (2010) 201.

Stöck, M., Ustinova, J., Lamatsch, D.K., Schartl, M., Perrin, N. and Moritz, C.: A vertebrate reproductive system involving three ploidy levels: Hybrid origin of triploids in a contact zone of diploid and tetraploid. Evolution 64 (2009) 944-959.

Schories, S., Meyer, M.K. and Schartl, M.: Description of Poecilia (Acanthophacelus) obscura n. sp., (Teleostei: Poeciliidae), a new guppy species from western Trinidad, with remarks on P. wingei and the status of the "Endler's guppy". Zootaxa (2009) 35-50.

Leikam, C., Hufnagel, A., Schartl, M. and Meierjohann, S.: Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence. Oncogene 27 (2008) 7070-82.

Hassel, J.C., Winnemoller, D., Schartl, M. and Wellbrock, C.: STAT5 contributes to antiapoptosis in melanoma. Melanoma Res 18 (2008) 378-85.

Maier, S.M., Scherer, S.J., Seifert, M., Hanselmann, R.G., Schleehuber, Y., Edelmann, L., Reichrath, J., Krohne, G., Rescher, U., Seidl, W., Mutschler, W., Claes, L., Welter, C. and Schartl, M.: 1[alpha],25-dihydroxyvitamin D(3) enhances annexin II dependent proliferation of osteoblasts. J Cell Biochem 100 (2007) 679-692.

Wellbrock, C., Weisser, C., Hassel, J.C., Fischer, P., Becker, J., Vetter, C.S., Behrmann, I., Kortylewski, M., Heinrich, P.C. and Schartl, M.: STAT5 contributes to interferon resistance of melanoma cells. Curr Biol 15 (2005) 1629-39.

Wellbrock, C., Weisser, C., Geissinger, E., Troppmair, J. and Schartl, M.: Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling. J Biol Chem 277 (2002) 6443-54.
96. Stöck, M., Lamatsch, D.K., Steinlein, C., Epplen, J.T., Grosse, W.R., Hock, R., Klapperstück, T., Lampert, K.P., Scheer, U., Schmid, M. and Schartl, M.: A bisexually reproducing all-triploid vertebrate. Nat Genet 30 (2002) 325-8.

Scherer, S.J., Maier, S.M., Seifert, M., Hanselmann, R.G., Zang, K.D., Müller-Hermelink, H.K., Angel, P., Welter, C. and Schartl, M.: p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV. J Biol Chem 275 (2000) 37469-73.

Nanda, I., Shan, Z., Schartl, M., Burt, D.W., Koehler, M., Nothwang, H., Grutzner, F., Paton, I.R., Windsor, D., Dunn, I., Engel, W., Staeheli, P., Mizuno, S., Haaf, T. and Schmid, M.: 300 million years of conserved synteny between chicken Z and human chromosome 9. Nat Genet 21 (1999) 258-9.

Wittbrodt, J., Shima, A., and Schartl, M. (2002) Medaka--a model organism from the far East. Nat. Rev. Genet.. 3(1):53-64