ZFIN Person: Mongera, Alessandro

ZFIN ID: ZDB-PERS-230828-1

ZFIN ID: ZDB-PERS-230828-1

Mongera, Alessandro

Email:	a.mongera@ucl.ac.uk
URL:
Affiliation:	Mongera Lab
Address:	Department of Cell and Developmental Biology University College London Anatomy Building 221 Gower Street, London WC1E 6BT
Country:	United Kingdom
Phone:	0044 (0) 7947927655
Fax:
ORCID ID:	0000-0001-9344-9808

BIOGRAPHY AND RESEARCH INTERESTS

I obtained my PhD under the supervision of Christiane Nüsslein-Volhard (Max Planck Institute for Developmental Biology, Germany) and conducted postdoctoral training with Otger Campàs (UC Santa Barbara, USA) and Olivier Pourquié (Harvard Medical School, USA). My current research interests lie at the intersection of tissue mechanics, metabolism, and evolution.

PUBLICATIONS

Mongera, A., Pochitaloff, M., Gustafson, H.J., Stooke-Vaughan, G.A., Rowghanian, P., Kim, S., Campàs, O. (2022) Mechanics of the cellular microenvironment as probed by cells in vivo during zebrafish presomitic mesoderm differentiation. Nature Materials. 22(1):135-143

Mongera, A., Rowghanian, P., Gustafson, H.J., Shelton, E., Kealhofer, D.A., Carn, E.K., Serwane, F., Lucio, A.A., Giammona, J., and Campàs, O. (2018) A fluid-to-solid jamming transition underlies vertebrate body axis elongation.. Nature. 561:401-405

Facchinello, N., Tarifeño-Saldivia, E., Grisan, E., Schiavone, M., Peron, M., Mongera, A., Ek, O., Schmitner, N., Meyer, D., Peers, B., Tiso, N., Argenton, F. (2017) Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration. Scientific Reports. 7:9605

Hockman, D., Burns, A., Schlosser, G., Gates, K.P., Jevans, B., Mongera, A., Fisher, S., Unlu, G., Knapik, E.W., Kaufman, C.K., Mosimann, C., Zon, L.I., Lancman, J.J., Dong, P.D., Lickert, H., Tucker, A.S., Baker, C.V. (2017) Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. eLIFE. 6

Serwane, F., Mongera, A., Rowghanian, P., Kealhofer, D.A., Lucio, A.A., Hockenbery, Z.M., Campàs, O. (2017) In vivo quantification of spatially varying mechanical properties in developing tissues. Nature Methods. 14(2):181-186

Wang, L., Mongera, A., Bonanomi, D., Cyganek, L., Pfaff, S.L., Nüsslein-Volhard, C., Marquardt, T. (2014) A conserved axon type hierarchy governing peripheral nerve assembly. Development (Cambridge, England). 141:1875-83

Mongera, A., and Nüsslein-Volhard, C. (2013) Scales of fish arise from mesoderm. Current biology : CB. 23(9):R338-339

Dooley, C.M., Mongera, A., Walderich, B., and Nüsslein-Volhard, C. (2013) On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development (Cambridge, England). 140(5):1003-1013

Dooley, C.M., Schwarz, H., Mueller, K.P., Mongera, A., Konantz, M., Neuhauss, S.C., Nüsslein-Volhard, C., and Geisler, R. (2013) Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease. Pigment cell & melanoma research. 26(2):205-217

Mongera, A., Singh, A.P., Levesque, M.P., Chen, Y.Y., Konstantinidis, P., and Nüsslein-Volhard, C. (2013) Genetic lineage labeling in zebrafish uncovers novel neural crest contributions to the head, including gill pillar cells. Development (Cambridge, England). 140(4):916-925

Mongera, A. (2013) The role of neural crest in vertebrate evolution : tissue-specific genetic labeling in zebrafish (Danio rerio) reveals neural crest contribution to gills, but not to scales. Thesis. :108

Dodge, M.E., Moon, J., Tuladhar, R., Lu, J., Jacob, L.S., Zhang, L.S., Shi, H., Wang, X., Moro, E., Mongera, A., Argenton, F., Karner, C.M., Carroll, T.J., Chen, C., Amatruda, J.F., and Lum, L. (2012) Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine. The Journal of biological chemistry. 287(27):23246-23254

Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R.M., Bournele, D., Domenichini, A., Valdivia, L.E., Lum, L., Chen, C., Amatruda, J.F., Tiso, N., Weidinger, G., and Argenton, F. (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Developmental Biology. 366(2):327-340

NON-ZEBRAFISH PUBLICATIONS
Capovilla G, Braakman R, Fournier GP, Hackl T, Schwartzman J, Lu X, Yelton A, Longnecker K, Soule MCK, Thomas E, Swarr G, Mongera A, Payette JG, Castro KG, Waldbauer JR, Kujawinski EB, Cordero OX, Chisholm SW. Chitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2213271120. doi: 10.1073/pnas.2213271120. Epub 2023 May 9. PMID: 37159478; PMCID: PMC10194020.

Miao Y, Djeffal Y, De Simone A, Zhu K, Lee JG, Lu Z, Silberfeld A, Rao J, Tarazona OA, Mongera A, Rigoni P, Diaz-Cuadros M, Song LMS, Di Talia S, Pourquié O. Reconstruction and deconstruction of human somitogenesis in vitro. Nature. 2023 Feb;614(7948):500-508. doi: 10.1038/s41586-022-05655-4. Epub 2022 Dec 21. PMID: 36543321; PMCID: PMC10018515.

Mongera A, Michaut A, Guillot C, Xiong F, Pourquié O. Mechanics of Anteroposterior Axis Formation in Vertebrates. Annu Rev Cell Dev Biol. 2019 Oct 6;35:259-283. doi: 10.1146/annurev-cellbio-100818-125436. Epub 2019 Aug 14. PMID: 31412208; PMCID: PMC7394480.

Lucio AA, Mongera A, Shelton E, Chen R, Doyle AM, Campàs O. Spatiotemporal variation of endogenous cell-generated stresses within 3D multicellular spheroids. Sci Rep. 2017 Sep 20;7(1):12022. doi: 10.1038/s41598-017-12363-x. PMID: 28931891; PMCID: PMC5607343.

Mongera A, Dooley CM. Of white tigers and solute carriers. Pigment Cell Melanoma Res. 2013 Nov;26(6):787-9. doi: 10.1111/pcmr.12163. Epub 2013 Sep 23. PMID: 24011081.