ZFIN Person: Karasik, David

ZFIN ID: ZDB-PERS-210223-1

ZFIN ID: ZDB-PERS-210223-1

Karasik, David

Email:	david.karasik@biu.ac.il
URL:	http://research.md.biu.ac.il/labs/david-karasik/
Affiliation:	Karasik Lab
Address:	Azrieli Faculty of Medicine Bar-Ilan University 8 Henrietta Szold St P.O. Box 1589 Safed, 1311502
Country:	Israel
Phone:	617-971-5372
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

The primary objective of our research is to understand the biology behind the function and pathology of complex physiological systems and metabolic processes. Our research focuses on identifying genes involved in the genetic variation of complex traits, including bone mass, muscle (lean) mass, and fatty liver.

PUBLICATIONS

Medina-Gomez, C., Mullin, B.H., Chesi, A., Prijatelj, V., Kemp, J.P., Shochat-Carvalho, C., Trajanoska, K., Wang, C., Joro, R., Evans, T.E., Schraut, K.E., Li-Gao, R., Ahluwalia, T.S., Zillikens, M.C., Zhu, K., Mook-Kanamori, D.O., Evans, D.S., Nethander, M., Knol, M.J., Thorleifsson, G., Prokic, I., Zemel, B., Broer, L., McGuigan, F.E., van Schoor, N.M., Reppe, S., Pawlak, M.A., Ralston, S.H., van der Velde, N., Lorentzon, M., Stefansson, K., Adams, H.H.H., Wilson, S.G., Ikram, M.A., Walsh, J.P., Lakka, T.A., Gautvik, K.M., Wilson, J.F., Orwoll, E.S., van Duijn, C.M., Bønnelykke, K., Uitterlinden, A.G., Styrkársdóttir, U., Akesson, K.E., Spector, T.D., Tobias, J.H., Ohlsson, C., Felix, J.F., Bisgaard, H., Grant, S.F.A., Richards, J.B., Evans, D.M., van der Eerden, B., van de Peppel, J., Ackert-Bicknell, C., Karasik, D., Kague, E., Rivadeneira, F. (2023) Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. Communications biology. 6:691691

Grinberg, L., Dabbah Assadi, F., Baum, G., Zemel, R., Tur-Kaspa, R., Shochat, C., Karasik, D., Karpuj, M.V. (2023) Beneficial Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease (NAFLD) Progression in the Zebrafish Model. Nutrients. 15(6):

Khrystoforova, I., Shochat-Carvalho, C., Harari, R., Henke, K., Woronowicz, K., Harris, M.P., Karasik, D. (2022) Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Frontiers in endocrinology. 13:985304

Mesika, A., Nadav, G., Shochat, C., Kalfon, L., Jackson, K., Khalaileh, A., Karasik, D., Falik-Zaccai, T.C. (2022) NGLY1 Deficiency Zebrafish Model Manifests Abnormalities of the Nervous and Musculoskeletal Systems. Frontiers in cell and developmental biology. 10:902969

Banerjee, B., Khrystoforova, I., Polis, B., Zvi, I.B., Karasik, D. (2021) Acute hypoxia elevates arginase 2 and induces polyamine stress response in zebrafish via evolutionarily conserved mechanism. Cellular and molecular life sciences : CMLS. 79(1):41

Bek, J.W., Shochat, C., De Clercq, A., De Saffel, H., Boel, A., Metz, J., Rodenburg, F., Karasik, D., Willaert, A., Coucke, P.J. (2021) Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 36(9):1749-1764

Tobias, J.H., Duncan, E.L., Kague, E., Hammond, C.L., Gregson, C.L., Bassett, D., Williams, G.R., Min, J.L., Gaunt, T.R., Karasik, D., Ohlsson, C., Rivadeneira, F., Edwards, J.R., Hannan, F.M., Kemp, J.P., Gilbert, S.J., Alonso, N., Hassan, N., Compston, J.E., Ralston, S.H. (2021) Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. Frontiers in endocrinology. 11:630875

Banerjee, B., Koner, D., Karasik, D., Saha, N. (2020) Genome-wide identification of novel long non-coding RNAs and their possible roles in hypoxic zebrafish brain. Genomics. 113(1 Pt 1):29-43

Shochat, C., Wang, Z., Mo, C., Nelson, S., Donaka, R., Huang, J., Karasik, D., Brotto, M. (2020) Deletion of SREBF1, a functional bone-muscle pleiotropic gene, alters bone density and lipid signaling in zebrafish. Endocrinology. 162(1):

Khajuria, D.K., Karasik, D. (2020) Novel model of restricted mobility induced osteopenia in zebrafish. Journal of Fish Biology. 98(4):1031-1038

NON-ZEBRAFISH PUBLICATIONS
Hsu, Y-H, Estrada, K, Evangelou, E … Rivadeneira F, Kiel DK, Karasik D. Meta-analysis of Genome-Wide Association Studies Reveals Genetic Variants for Hip Bone Geometry. J Bone & Mineral Research 2019 34(7):1284-129

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X... Karasik D ... Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019, 14;10(1):3669.
Granot-Hershkovitz E, Wu P, Karasik D, Peter I, Peloso G, Levy, Vasan R, Cupples L.A., Liu CT, Meigs J, Siscovick D, Dupuis J, Friedlander Y, and Hochner H. Searching for Parent-of-origin effects on cardiometabolic traits in imprinted genomic regions. European Journal of Human Genetics 2020: 28(5):646-655
Trajanoska K, Lotta J. Seppala, Carolina Medina-Gomez, Yi-Hsiang Hsu ... Karasik D ... DP. Kiel, AG. Uitterlinden, JR.B. Perry, N. van der Velde, FR. Day, F Rivadeneira. Genetic basis of falling risk susceptibility in the UK Biobank Study. Communications Biology 2020 [Paper #543]
Jones G*, K. Trajanoska*, A. J Santanasto*, N. Stringa*, C-L Kuo*, JL Atkins* … J M Murabito*, G A Kuchel*, L Ferrucci*, D Melzer*, D Karasik*, F Rivadeneira*, DP Kiel*, LC Pilling*. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun. 2021