|ZFIN ID: ZDB-PERS-210119-1|
BIOGRAPHY AND RESEARCH INTERESTS
I received my PhD degree from College of Fisheries, Huazhong Agriculture University, China in 2010. During my PhD study, I had been working as a visiting Ph.D. student in The Ohio State University, USA, researching in genetic breeding, sex determination and aquaculture biotechnology of freshwater economic fish particularly bluegill and yellow perch. After receiving my degree, I began to work in College of Fisheries, Huazhong Agricultural University, from a lecturer at 2010 to full professor at 2018. I had worked as a visiting scholar in Department of Molecular and Cellular Biology, University of California, Davis, USA, as well as Nofima, Norway. Now, my lab is focusing on the developmental biology and molecular mechanisms of fish bones, especially intermuscular bones. We try to use advanced molecular breeding, gene editing and traditional breeding technologies to breed freshwater economic aquaculture species with less or even without intermuscular bones. Zebrafish is used as model to reveal the gene functions on the important selected traits, which could be used in aquaculture species.
Nunes, J.R.S., Pértille, F., Andrade, S.C.S., Perazza, C.A., Villela, P.M.S., Almeida-Val, V.M.F., Gao, Z.X., Coutinho, L.L., Hilsdorf, A.W.S. (2020) Genome-wide association study reveals genes associated with the absence of intermuscular bones in tambaqui (Colossoma macropomum). Animal Genetics. 51:899-909
1)Nie CH, Hilsdorf AWS, Wan SM, Gao ZX(*). Understanding the development of intermuscular bones in teleost: status and future directions for aquaculture. Reviews in Aquaculture, 2020, 12: 759–772.
2)Liu, H(#); Chen, C(#); Gao, ZX(#); Min, JM(#); Gu, YM(#); Jian, JB(#); Jiang, XW; Cai, HM; Ebersberger, I; Xu, M; Zhang, XH; Chen, JW; Luo, W; Chen, BX; Chen, JH; Liu, H; Li, J; Lai, RF; Bai, MZ; Wei, J; Yi, SK; Wang, HL; Cao, XJ; Zhou, XY; Zhao, YH; Wei, KJ; Yang, RB; Liu, BN; Zhao, SC; Fang, XD; Schartl, M(*); Qian, XQ(*); Wang, WM(*). The draft genome of blunt snout bream (Megalobrama amblycephala) reveals the development of intermuscular bone and adaptation to herbivorous diet. GigaScience, 2017, 6(7): 1-13.
3)Wan SM, Xiong XM, Tomljanovic T, Chen YL, Liu H, Treer T, Gao ZX(*). Identification and mapping of SNPs associated with number of intermuscular bone in blunt snout bream. Aquaculture, 2019, 507, 75-82.
4)Xiong XM, Robinson NA, Zhou JJ, Chen YL, Wang WM, Wang XB, Gao ZX(*). Genetic parameter estimates for intermuscular bone in blunt snout bream (Megalobrama amblycephala) based on a microsatellite-based pedigree. Aquaculture, 2019, 502: 371–377.
5)Luo W, Wang WM, Wan SM, Lin Q, Gao ZX(*). Assessment of parental contribution to fast- and slow-growth progenies in the blunt snout bream (Megalobrama amblycephala) based on parentage assignment. Aquaculture, 2017, 472: 23-29.
6)Nie CH, Wan SM, Tomljanovic T, Treer T, Hsiao CD, Wang WM, Gao ZX(*). Comparative proteomics analysis of teleost intermuscular bones and ribs provides insight into their development. BMC Genomics, 2017, 18:147.
7)Wan SM, Liu H, Zhao BW, Nie CH, Wang WM, Gao ZX(*). Construction of a high-density linkage map and fine mapping of QTL for growth and gonad related traits in blunt snout bream. Scientific Reports, 2017, 7: 46509.
8)Wan SM, Yi SK, Zhong J, Nie CH, Guan NN, Chen BX, Gao ZX(*). Identification of microRNA for intermuscular bone development in blunt snout bream (Megalobrama amblycephala). International Journal of Molecular Sciences, 2015, 16(6): 10686-10703.
9)Wan SM, Yi SK, Zhong J, Nie CH, Guan NN, Zhang WZ, Gao ZX(*). Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala). Scientific Reports, 2016, 6: 31050.
10)Xiong XM, Chen YL, Liu LF, Wang WM, Robinson NA(*), Gao ZX(*). Estimation of genetic parameters for resistance to Aeromonas hydrophila in blunt snout bream (Megalobrama amblycephala). Aquaculture, 2017, 479: 768-773.
11)Guan NN, Zhou Q(*), Lan T, Zhou LF, Zhao BW, Wang WM, Gao ZX(*). Is the nutritional value of fish fillet related to fish maturation or fish age? Integrated analysis of transcriptomics and metabolomics in blunt snout bream (Megalobrama amblycephala). Cellular Physiology and Biochemistry, 2018, 49:17-39.
12)Zhang WZ, Lan T, Nie CH, Guan NN, Gao ZX(*). Characterization and spatiotemporal expression analysis of nine bone morphogenetic protein family genes during intermuscular bone development in blunt snout bream. Gene, 2018, 642: 116-124.
13)Zhou LF, Zhao BW, Guan NN, Wang WM, Gao ZX(*). Plasma metabolomics profiling for fish maturation in blunt snout bream. Metabolomics, 2017, 13(4): 40.
14)Zhao BW, Zhou LF, Liu YL, Wan SM, Gao ZX(*). Evolution of fish let-7 microRNAs and their expression correlated to growth development in blunt snout bream. International Journal of Molecular Sciences, 2017, 18(3): 646.
15)Zhang WZ, Xiong XM, Zhang XJ, Wan SM, Guan NN, Nie CH, Zhao BW, Hsiao CD, Wang WM, Gao ZX(*). Mitochondrial genome variation after hybridization and differences in the first and second generation hybrids of bream fishes. PLoS ONE, 2016, 11(7): e0158915.
16)Zhao H, Zeng C, Yi S, Wan S, Chen B, Gao ZX(*). Leptin genes in blunt snout bream: cloning, phylogeny and expression correlated to gonads development. International Journal of Molecular Sciences, 2015, 16(11): 27609–27624.
17)Tran NT, Gao ZX(*), Zhao HH, Yi SK, Chen BX, Zhao YH, Lin L, Liu XQ, Wang WM(*). Transcriptome analysis and microsatellite discovery in the blunt snout bream (Megalobrama amblycephala) after challenge with Aeromonas hydrophila. Fish & Shellfish Immunology, 2015, 45(1): 72-82.
18)Lan T, Chen YL, Gul Y, Zhao BW, Gao ZX(*). Comparative expression analysis of let-7 microRNAs during ovary development in Megalobrama amblycephala. Fish Physiology and Biochemistry, 2019, 45: 1101-1105.
19)Wen JF, Ruan GL, Zhao HH, Wang WM, Gao ZX(*). Molecular characterization and expression of Kiss2/Kiss2r during embryonic and larval development in (Megalobrama amblycephala Yih, 1955). Journal of Applied Ichthyology, 2016, 32(2): 288-295.
20)Luo W, Zeng C, Deng W, Robinson N, Wang W(*), Gao ZX(*). (2014) Genetic parameter estimates for growth-related traits of blunt snout bream (Megalobrama amblycephala) using microsatellite-based pedigree. Aquaculture Research, 2014, 45: 1881-1888.