ZFIN Person: Galperin, Emilia

ZFIN ID: ZDB-PERS-190826-19

ZFIN ID: ZDB-PERS-190826-19

Galperin, Emilia

Email:	emilia.galperin@uky.edu
URL:	http://galperinlab.com/
Affiliation:	Galperin Lab
Address:	Department of Molecular and Cellular Biochemistry 741 S Limestone st., Lexington KY
Country:	United States
Phone:	859-323-1796
Fax:
ORCID ID:	0000-0002-8743-026X

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Norcross, R.G., Abdelmoti, L., Rouchka, E.C., Andreeva, K., Tussey, O., Landestoy, D., Galperin, E. (2022) Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix. Developmental Biology. 492:156-171

Jang, H., Oakley, E., Forbes-Osborne, M., Kesler, M., Norcross, R., Morris, A.C., Galperin, E. (2018) Hematopoietic and neural crest defects in zebrafish shoc2 mutants: a novel vertebrate model for Noonan-like syndrome. Human molecular genetics. 28(3):501-514

NON-ZEBRAFISH PUBLICATIONS
1. Galperin., E.#, Abdelmoti L., and Sorkin. A. (2012) Targeting of Shoc2 to endosomes regulates ERK1/2 activation by the EGF receptor. PLoS One. 2012;7(5):e36469. Epub 2012 May 14. PMID: 22606262.

2. Jeoung MK., Abdelmoti L., Jang ER., Vander Kooi C.W. and Galperin E. “Functional integration of the conserved domains of Shoc2 scaffold” PLoS One 2013 Jun 21;8(6):e66067.

3. Jeoung MK., and Galperin E. Visualizing of Signaling Proteins on Endosomes Utilizing Knockdown and Reconstitution Approach. In P. Michael Conn, editor: Endosome Signaling Part A, Vol 534, MIE, UK: Academic Press, 2014, pp. 47-64.

4. Fuqua JL, Littrell OM, Lundblad M, Turchan-Cholewo J, Abdelmoti LG, Galperin E, Bradley LH, Cass WA, Gash DM, Gerhardt GA. Dynamic changes in dopamine neuron function after DNSP-11 treatment: Effects in vivo and increased ERK 1/2 phosphorylation in vitro. Peptides. 2014 Jan 7;54C:1-8. doi: 10.1016/j.peptides.2013.12.007.

5. Jang ER., Shi P., Bryant J., Chen J., Dukhante V. , Gentry MS, Jang HI., Jeoung MK., and Galperin E. “HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold”. Mol. Cell. Biol. (published ahead of print 23 June 2014, doi:10.1128/MCB.00677-14).

6. Hannig V., Jeoung MK., Jang ER., Phillips JA III and Galperin E. A Novel Shoc2 variant in Rasopathy. Human Mutation (014 Nov;35(11):1290-4. doi: 10.1002/humu.22634. Epub 2014 Sep 11.

7. Jang ER., Jang HI, Shi P., Jeoung MK., Popa G., and Galperin E. Spatial control of Shoc2 scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5. J Cell Sci. 2015 Oct 30. pii: jcs.177543.

8. Jeoung MK, Jang ER, Liu J, Wang C, Rouchka EC, Li X, Galperin E. Shoc2-tranduced ERK1/2 motility signals – Novel insights from functional genomics. Cell. Signal. 2016 Feb 11;28(5):448-459. doi: 10.1016/j.cellsig.2016.02.005. PMID:26876614.

9. Rouchka EC, Jeoung M, Jang ER, Liu J, Wang C, Li X, Galperin E. Data set for transcriptional response to depletion of the Shoc2 scaffolding protein. Data in Brief. 2016 Mar 9;7:770-8. doi: 10.1016/j.dib.2016.03.012. eCollection 2016 Jun. PMID: 27077079

10. Jang ER and Galperin E. The function of Shoc2:-A scaffold and beyond. Communicative & Integrative Biology 2016 May 18;9(4):e1188241. doi: 10.1080/19420889.2016.1188241. eCollection 2016 Jul-Aug. PMID:27574535

11. Song ES, Jang HI, Guo HF, Juliano A, Juliano L, Morris AJ, Galperin E, Rodgers DW., Hersh LB. Inositol phosphates and phosphoinositides activate insulin degrading enzyme while phosphoinositides also mediate binding to endosomes. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2826-E2835. doi: 10.1073/pnas.1613447114. Epub 2017 Mar 21.

12. Jang HI, Jang ER, Anderson, D., Jeoung MK. and Galperin E. VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology. Mol Biol Cell. 2019 May 15: mbcE19030144. doi: 10.1091/mbc.E19-03-0144. [Epub ahead of print] PMID: 31091164