ZFIN Person: Fladmark, Kari E.

ZFIN ID: ZDB-PERS-190117-1

ZFIN ID: ZDB-PERS-190117-1

Fladmark, Kari E.

Email:	Kari.fladmark@uib.no
URL:	http://www.uib.no/en/persons/Kari.Espolin.Fladmark
Affiliation:	Fladmark Lab
Address:	Department of Biological Science University of Bergen Thormohlensgt. 55, 5020 Bergen Norway
Country:
Phone:	+47 55 584514
Fax:
ORCID ID:	0000-0003-4463-8404

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Førde, J.L., Reiten, I.N., Fladmark, K.E., Kittang, A.O., Herfindal, L. (2022) A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae. Biology Open. 11(12):

Gharbi, N., Røise, D., Førre, J.E., Edson, A.J., Hushagen, H.A., Tronci, V., Frøyset, A.K., Fladmark, K.E. (2021) Reintroduction of DJ-1 in Müller Cells Inhibits Retinal Degeneration in the DJ-1 Deficient Retina. Antioxidants (Basel, Switzerland). 10(12):

Edson, A.J., Hushagen, H.A., Frøyset, A.K., Elda, I., Khan, E.A., Di Stefano, A., Fladmark, K.E. (2019) Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1. Molecular neurobiology. 56(12):8306-8322

NON-ZEBRAFISH PUBLICATIONS
Egea et al (2017) European Contribution to the study of ROS: A Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS). Redox Biology https://doi.org/10.1016/j.redox.2017.05.007

Hjørnevik LV , Frøyset AK, Grønset TA, Rungruangsak-Torrissen K, and Fladmark KE (2015) The Algal Toxin Azaspiracid-1 Induces an Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry Marine Drugs 13, 7390-7402.

Pajares M, Jimineze-Moreno N, Dias I, Debelec B, Vucetic M, Fladmark KE, Basaga H, Ribaric S, Milisav I, Cuadrado A (2015) Redox control of protein degradation. Redox Biology 6:409-20.

Opsahl JA, Ljostveit S, Solstad T, Risa K, Roepstorff P, and Fladmark KE (2013) Identification of dynamic changes in proteins associated with the cellular cytoskeleton after exposure to okadaic acid. Marine Drugs 11:1763-82.

Kamil A, Raae A, Fjelldal PG, Koppang EO, Fladmark KE, Hordvik I (2013) Comparative analysis of IgM sub-variants in salmonid fish and identification of a residue in m3 which is essential for MAb4C10 reactivity. Fish and Shellfish Immunology 34: 667-72.

Hjørnevik LV, Fismen L, Young FM, Solstad T , Fladmark KE (2012) Nodularin exposure induces SOD1 phosphorylation and distrupts SOD1 co-localization with actin. Toxins 4:1482-1499.

de Vareilles M, Richard N, Gavaia PJ, Silva TS., Cordeiro O, Guerreiro I, Yúfera M, Batista I, Pires C, Pousão-Ferreira P, Rodrigues PM, Rønnestad I, Fladmark KE, Conceição LEC (2012) Impact of dietary protein hydrolysates on skeleton quality and proteome in Diplodus sargus larvae. J Appl Ichthyol 28: 477-87.

Oveland, E, Wergeland, L, Hovland, R., Lorens JB, Gjertsen, BT,and Fladmark KE. (2012) Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. Cell Biology and Toxicology 28:201-12.

Opsahl J.A., Hjørnevik L.V., Bull V.H., Fismen L, Gromyko D., Solstad T. and Fladmark KE (2010) Increased interaction between DJ-1 and the Mi-2/NuRD complex during cellular stress. Proteomics 10: 1-11.

Herfindal L, Kasprzykowski F, Schwede F, Lankiewicz L, Fladmark KE, Lukomska J, Wahlsten M, Sivonen K, Grzonka Z, Jastorff B, Døskeland SO (2009) Synthesis and activity of bioactivatable protoxins of nodularin and microcystin. J. Med. Chem. Epubl. Aug. 25.

Kellmann, R, Grønseth T, Schaffner C, Satake, M and Fladmark, KE (2009) Proteomic response of human neuroblastoma cells to azaspiracid. J. Proteomics 72: 695-707.

Oveland E, Gjertsen BT, Wergeland L, Selheim F, Fladmark KE, Hovland R (2008)
Ligand induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Leukemia Research 33: 276-87.

Solstad T., Bull V., Breivik L. and Fladmark KE (2008) Identification of protein interaction partners by immunoprecipitation; possible pitfalls and false positives. Experimental and Clinical Hepatology 4:16-22.

Solstad T, Fismen L, Garberg H and Fladmark KE (2008) Identification of a novel phosphorylation site of Acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes. Exp. Cell. Res. 314: 2141-9.

H. Målen, F. S. Berven, K. E. Fladmark and H. G. Wiker (2007) Defining the Secreted Proteome of Mycobacterium tuberculosis by analysis of a Unique Culture Filtrate using a Mass Spectrometry Based Proteomic Profiling approach. Proteomics 7: 1702-18.

Oveland E, Fladmark KE, Wergeland L, Gjertsen BT and Hovland R (2006) Proteomic approaches to elucidate oncogenic tyrosine kinase signalling in myeloid malignancies Curr Pharm Biotechnol 7:185-198.

Solstad T and Fladmark KE (2006) Algal toxins as guidance to identify phosphoproteins with key roles in apoptotic cell death. Curr Pharm Biotechnol 7: 209-215.

Krakstad CK , Herfindal L., Gjertsen BT , Boe R , Fladmark KE , Døskeland SO (2006) CaM-kinaseII dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Diff. 13: 1191-1202.

Gausdal G, Gjertsen BT, Fladmark KE, Demol H, Vandekerckhove J, Doskeland SO (2004) Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis . Leukemia 18: 1989-1996.

Hans J. Grav, Karl J. Tronstad, Oddrun A. Gudbrandsen, Kjetil Berge, Kari E. Fladmark, Tom Christian Martinsen, Hege Wergedahl and Rolf K. Berge. (2003) Changed energy state and increased mitochondrial {bet}-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated UCP-2 Expression evidence for PPAR independent induction of UCP2 expression J. Biol. Chem. 278: 30525-33.

Fladmark, K.E, Brustugun, O.T., Mellgren, G., Krakstad, C., Bøe, R., Vintermyr, O.K., Schulman, H.,and Døskeland, S.O. (2002) Ca2+/calmodulin-dependent protein kinase II activity is required for apoptosis induced by phosphatase inhibitors. J. Biol. Chem. 277 : 2804-2811.

Mankiewicz J, Tarczynska M, Fladmark KE, Doskeland SO, Walter Z, Zalewski M. (2001) Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environ. Toxicol. 16: 225-233.

Mankiewicz, J., Walter, Z., Tarcynska, M., Zalewski, M., Fladmark, K.E., and Døskeland, S.O. (2000) Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. Int. J. Occup. Med. Environ. Health 13: 335-344.

Serres, M., Fladmark, K.E., and Døskeland, S.O. (2000) An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon 38: 347-360.

Fladmark, K.E., Brustugun, O.T ., Hovland, R., Bøe, Gjertsen,B.T., Zhivotovsky,B., and Døskeland, S.O. (1999) Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors. Cell Death Differentiation 6: 1099-1100.

Jensen, P.H., Fladmark, K.E., Gjertsen, B.T., and Vintermyr, O.K. (1999) Caspase I related protease inhibition retards the execution of okadaic acid and camptothecin induced apoptosis and PAI-2 selective cleavage, but not commitment to cell death in HL-60 cells. Br. J. Cancer 79: 1685-1691.

Fladmark, K.E., Serres, M.H., Larsen, N.L., Yasumoto, T., T. Aune and Døskeland, S.O. (1998) Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes. Toxicon 36: 1101-1114.

Brustugun, O.T., Fladmark, K.E , Døskeland, S.O, Orrenius, S., Zhivotovsky, B (1998) Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inibited by Bcl-2. Cell Death and Differentiation 5: 660-668.

Fladmark, K.E., Gjertsen, B.T., Døskeland, S.O. and Vintermyr, O.K. (1997)
Fas/Apo-1 (CD-95) induced apoptosis of primary hepatocytes is inhibited by cAMP Biochemical Biophysical Research Communication 232: 20-25.

Fladmark, K.E., Gjertsen, B.T., Molven, A., Mellgren, G., Vintermyr, O.K., and Døskeland, S.O. (1997) Gap junctions are consistently downregulated before hepatocyte DNA replication, but are non-essential for the antiproliferative actions of cAMP, dexamethasone and high cell density. HEPATOLOGY 25: 847-855.

Zorn, M., Fladmark, K.E., Øgreid, D., Jastorff, B., Døskeland, S.O., Dostmann, W.R.G. (1995) Ala335 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I. FEBS Lett. 362:291-294.