Person
Hortle, Elinor
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Biography and Research Interest
- Kam, J.Y., Hortle, E., Krogman, E., Warner, S.E., Wright, K., Luo, K., Cheng, T., Manuneedhi Cholan, P., Kikuchi, K., Triccas, J.A., Britton, W.J., Johansen, M.D., Kremer, L., Oehlers, S.H. (2022) Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish. Nature communications. 13:952
- Tran, W., Kusay, A.S., Hawkins, P.M.E., Cheung, C.Y., Nagalingam, G., Pujari, V., Ford, D.J., Stoye, A., Ochoa, J.L., Audette, R.E., Hortle, E., Oehlers, S.H., Charman, S.A., Linington, R.G., Rubin, E.J., Dowson, C.G., Roper, D.I., Crick, D.C., Balle, T., Cook, G.M., Britton, W.J., Payne, R.J. (2021) Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors. Journal of medicinal chemistry. 64(23):17326-17345
- Oehlers, S.H., Hortle, E., Cook, K.M. (2020) A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention. The FEBS journal. 287(18):3917-3920
- Black, H.D., Xu, W., Hortle, E., Roberston, S.I., Britton, W.J., Kaur, A., New, E.J., Witting, P.K., Chami, B., Oehlers, S.H. (2019) The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free radical biology & medicine. 135:157-166
- Hortle, E., Johnson, K.E., Johansen, M.D., Nguyen, T., Shavit, J.A., Britton, W.J., Tobin, D.M., Oehlers, S.H. (2019) Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish. The Journal of infectious diseases. 220(3):524-534
- Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S.S.L., Formella, I., Hortle, E., Yuan, K.C., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2018) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 28(4):698
- Johansen, M.D., Hortle, E., Kasparian, J.A., Romero, A., Novoa, B., Figueras, A., Britton, W.J., de Silva, K., Purdie, A.C., Oehlers, S.H. (2018) Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish & shellfish immunology. 83:238-242
- Johansen, M.D., Kasparian, J.A., Hortle, E., Britton, W.J., Purdie, A.C., Oehlers, S.H. (2018) Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models. Developmental and comparative immunology. 88:169-172
- Spain, M., Wong, J.K., Nagalingam, G., Batten, J.M., Hortle, E., Oehlers, S., Jiang, X.F., Murage, H.E., Orford, J.T., Crisologo, P., Triccas, J.A., Rutledge, P.J., Todd, M.H. (2018) Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies. Journal of medicinal chemistry. 61(8):3595-3608
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Non-Zebrafish Publications