ZFIN ID: ZDB-PERS-170606-7
O'Brien, John
Email: John.OBrien@uth.tmc.edu
URL: https://gsbs.uth.edu/faculty/faculty-directory/faculty-profiles.htm?id=1346451
Affiliation: O'Brien Lab
Address: Department of Ophthalmology & Visual Science The University of Texas Health Science Center, Houston 6431 Fannin St., MSB 7.024 Houston, TX 77030
Country: United States
Phone: (713) 500-5983
Fax: (713) 500-0682
ORCID ID: 0000-0002-0270-3442


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Santhanam, A., Shihabeddin, E., Atkinson, J.A., Nguyen, D., Lin, Y.P., O'Brien, J. (2020) A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors. Cells. 9(10):
Miller, A.C., Whitebirch, A.C., Shah, A.N., Marsden, K.C., Granato, M., O'Brien, J., Moens, C.B. (2017) A genetic basis for molecular asymmetry at vertebrate electrical synapses. eLIFE. 6:e25364
Yoshikawa, S., Vila, A., Segelken, J., Lin, Y.P., Mitchell, C.K., Nguyen, D., O'Brien, J. (2017) Zebrafish Connexin 79.8 (Gja8a): A lens connexin used as an electrical synapse in some neurons. Developmental Neurobiology. 77(5):548-561
Li, H., Chuang, A.Z., O'Brien, J. (2014) Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Visual neuroscience. 31:237-43
Li, H., Chuang, A.Z., and O'Brien, J. (2009) Photoreceptor coupling is controlled by connexin 35 phosphorylation in zebrafish retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48):15178-15186

NON-ZEBRAFISH PUBLICATIONS
O’Brien, J., Al-Ubaidi, M.R., and Ripps, H.: Connexin 35: A gap junctional protein expressed preferentially in the skate retina. Mol. Biol. Cell 7: 233-243, 1996. PMCID: PMC275876
O’Brien, J., Bruzzone, R., White, T.W., Al-Ubaidi, M.R., and Ripps, H.: Cloning and expression of two related connexins from the perch retina define a new subgroup of the connexin family. J. Neurosci. 18 (19): 7625-7637, 1998.
White, T.W., Deans, M.R., O’Brien, J., Al-Ubaidi, M.R., Goodenough, D.A., Ripps, H., and Bruzzone, R.: Functional characteristics of skate connexin35, a member of the γ subfamily of connexins expressed in the vertebrate retina. Eur. J. Neurosci. 11(6): 1883-1890, 1999.
Pereda, A., O'Brien, J., Nagy, J.I., Bukauskas, F., Davidson, K.G.V., Yasumura, T., and Rash, J.E. Connexin35 mediates electrical transmission at mixed synapses on Mauthner cells. J. Neurosci. 23(20): 7489-7503, 2003. PMCID: PMC1805790
O’Brien, J., Nguyen, H.B., and Mills, S.L. Cone photoreceptors in bass retina use two connexins to mediate electrical coupling. J. Neurosci. 24(24): 5632-5642, 2004. PMCID: PMC2222551
Ouyang, X., Winbow, V.M., Patel, L.S., Burr, G.S., Mitchell, C.K., and O’Brien, J. Protein kinase A mediates reversible regulation of electrical synapses containing connexin35 through a complex pathway. Mol. Brain Res. 135(1-2): 1-11, 2005. PMCID: PMC2212611
Burr, G.S., Mitchell, C.K., Keflemariam, Y.J., Heidelberger, R., and O’Brien, J. Calcium-dependent binding of calmodulin to retinal gap junction proteins. Biochem. Biophys. Res. Comm. 335: 1191-1198, 2005. PMCID: PMC2222552
Patel, L.S., Mitchell, C.K., Dubinsky, W.P., and O’Brien, J. Regulation of gap junction coupling through the neuronal connexin Cx35 by nitric oxide and cGMP. Cell Commun. Adhes. 13(1-2): 41-54, 2006. PMCID: PMC2189984
Kothmann, W.W., X. Li, Burr, G.S., and O’Brien, J. Connexin35/36 is phosphorylated at regulatory sites in the retina. Vis. Neurosci. 24(3): 363-375, 2007. PMCID: PMC2170900
Kothmann, W.W., Massey, S.C., and O’Brien, J. Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling. J. Neurosci. 29(47): 14903-14911, 2009. PMCID: PMC2839935
Kothmann, W.W., Trexler, E.B., Whitaker, C.M., Li, W., Massey, S.C., and O’Brien, J. Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network. J. Neurosci. 32(20): 6747-6759, 2012. PMCID: PMC3367513
Li, H., Zhang, Z., Blackburn, M.R., Wang, S.W., Ribelayga, C.P. and O'Brien, J. Adenosine and dopamine receptors co-regulate photoreceptor coupling via gap junction phosphorylation in mouse retina. J. Neurosci. 33(7): 3135-3150, 2013. PMCID: PMC3711184.
Rash, J.E., Curti, S., Davidson, K.G.V., Kamasawa, N., Nannapaneni, S., Flores, C.E., Yasumura, T., O’Brien, J., Lynn, B.D., Nagy, J.I., and Pereda, A.E. Molecular and functional asymmetry at a vertebrate electrical synapse. Neuron 79(5): 957-969, 2013. PMCID: PMC4020187.