ZFIN ID: ZDB-PERS-170320-1
Harrison, Michael
Email: mrh4003@med.cornell.edu
URL: http://www.labharrison.com
Affiliation: Harrison Lab
Address: Weill Cornell Medical College 413 East 69th St BB-560A New York, NY 10021
Country: United States
Phone:
Fax:
ORCID ID: 0000-0003-1703-9879


BIOGRAPHY AND RESEARCH INTERESTS
The development of zebrafish coronary and lymphatic vasculature and their role in heart regeneration.

- Vascularization of the juvenile zebrafish heart and identification of CXCL12 as a key player in mediating this process (Harrison et al., 2015).
- The development of the cardiac lymphatic system and understanding its important role during regeneration in reducing scar formation after injury (Harrison et al., 2019).
- Development of novel imaging and genomic approaches (Yip, Harrison et al., 2019; Bai et al., 2020).
- The development of high throughput drug screening methodologies using zebrafish larvae (Baxendale et al., 2012).
- The role of HDAC1 in zebrafish hindbrain neurogenesis (Harrison et al., 2011).


PUBLICATIONS
Bai, H., Liu, L., An, K., Lu, X., Harrison, M., Zhao, Y., Yan, R., Lu, Z., Li, S., Lin, S., Liang, F., Qin, W. (2020) CRISPR/Cas9-mediated precise genome modification by a long ssDNA template in zebrafish. BMC Genomics. 21:67
Yip, J.K., Harrison, M., Villafuerte, J., Fernandez, G.E., Petersen, A.P., Lien, C.L., McCain, M.L. (2019) Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device. Lab on a Chip. 20(2):274-284
Harrison, M.R., Feng, X., Mo, G., Aguayo, A., Villafuerte, J., Yoshida, T., Pearson, C.A., Schulte-Merker, S., Lien, C.L. (2019) Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration. eLIFE. 8:
Rubin, N., Harrison, M.R., Krainock, M., Kim, R., Lien, C.L. (2016) Recent advancements in understanding endogenous heart regeneration- insights from adult zebrafish and neonatal mice. Seminars in cell & developmental biology. 58:34-40
Harrison, M.R., Bussmann, J., Huang, Y., Zhao, L., Osorio, A., Burns, C.G., Burns, C.E., Sucov, H.M., Siekmann, A.F., Lien, C.L. (2015) Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell. 33:442-54
Li, R., Beebe, T., Jen, N., Yu, F., Takabe, W., Harrison, M., Cao, H., Lee, J., Yang, H., Han, P., Wang, K., Shimizu, H., Chen, J., Lien, C.L., Chi, N.C., Hsiai, T.K. (2014) Shear Stress-Activated Wnt-Angiopoietin-2 Signaling Recapitulates Vascular Repair in Zebrafish Embryos. Arterioscler. Thromb. Vasc. Biol.. 34(10):2268-75
Huang, Y., Harrison, M.R., Osorio, A., Kim, J., Baugh, A., Duan, C., Sucov, H.M., and Lien, C.L. (2013) Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. PLoS One. 8(6):e67266
Park, J., Cummins, T.M., Harrison, M., Lee, J., Zhou, Q., Lien, C.L., and Shung, K.K. (2013) High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart. Optics express. 21(12):14636-14642
Baxendale, S., Holdsworth, C.J., Santoscoy, P.M., Harrison, M.R., Fox, J., Parkin, C.A., Ingham, P.W., and Cunliffe, V.T. (2012) Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures. Disease models & mechanisms. 5(6):773-784
Lien, C.L., Harrison, M.R., Tuan, T.L., and Starnes, V.A. (2012) Heart repair and regeneration: Recent insights from zebrafish studies. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 20(5):638-646
Harrison, M.R., Georgiou, A.S., Spaink, H.P., and Cunliffe, V.T. (2011) The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos. BMC Genomics. 12(1):24
Lightman, E.G., Harrison, M.R., and Cunliffe, V.T. (2011) Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis. The International journal of developmental biology. 55(6):597-602

NON-ZEBRAFISH PUBLICATIONS