ZFIN ID: ZDB-PERS-160817-2
Helleday, Thomas
Email: thomas.helleday@scilifelab.se
Affiliation: Helleday Lab
Address: Science for Life Laboratory Karolinska Institutet Division of Translational Medicine and Chemical Biology SciLifeLab, KISP alfa PO Box 1031 171 21 Stockholm Sweden
Country: Sweden


Scaletti, E.R., Vallin, K.S., Bräutigam, L., Sarno, A., Berglund, U.W., Helleday, T., Stenmark, P., Jemth, A.S. (2020) MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. The Journal of biological chemistry. 295(15):4761-4772
Das, I., Gad, H., Bräutigam, L., Pudelko, L., Tuominen, R., Höiom, V., Almlöf, I., Rajagopal, V., Hansson, J., Helleday, T., Egyházi Brage, S., Warpman Berglund, U. (2020) AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma. Cell death and differentiation. 27(7):2081-2098
Jemth, A.S., Gustafsson, R., Bräutigam, L., Henriksson, L., Vallin, K.S.A., Sarno, A., Almlöf, I., Homan, E., Rasti, A., Warpman Berglund, U., Stenmark, P., Helleday, T. (2018) MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP. Nucleic acids research. 46(20):10888-10904
Pudelko, L., Edwards, S., Balan, M., Nyqvist, D., Al-Saadi, J., Dittmer, J., Almlöf, I., Helleday, T., Bräutigam, L. (2018) An orthotopic glioblastoma animal model suitable for high-throughput screenings. Neuro-Oncology. 20(11):1475-1484
Narwal, M., Jemth, A.S., Gustafsson, R., Almlöf, I., Warpman Berglund, U., Helleday, T., Stenmark, P. (2018) Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. Biochemistry. 57:593-603
Pudelko, L., Rouhi, P., Sanjiv, K., Gad, H., Kalderén, C., Höglund, A., Squatrito, M., Schuhmacher, A.J., Edwards, S., Hägerstrand, D., Berglund, U.W., Helleday, T., Bräutigam, L. (2017) Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Oncotarget. 8:84671-84684
Bräutigam, L., Pudelko, L., Jemth, A.S., Gad, H., Narwal, M., Gustafsson, R., Karsten, S., Carreras-Puigvert, J., Homan, E., Berndt, C., Warpman Berglund, U., Stenmark, P., Helleday, T. (2016) Hypoxic signaling and the cellular redox tumor environment determine sensitivity to MTH1 inhibition. Cancer research. 76(8):2366-75