ZFIN Person: Chiavacci, Elena

ZFIN ID: ZDB-PERS-150722-2

ZFIN ID: ZDB-PERS-150722-2

Chiavacci, Elena

Email:	elena.chiavacci@sns.it
URL:
Affiliation:
Address:	Scuola Normale Superiore Piazza dei Cavalieri, 7 56126 Pisa
Country:	Italy
Phone:
Fax:
ORCID ID:	0000-0003-3924-3635

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857

Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458

Kirchgeorg, L., Felker, A., van Oostrom, M., Chiavacci, E., Mosimann, C. (2018) Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(10):1146-1159

Guzzolino, E., Chiavacci, E., Ahuja, N., Mariani, L., Evangelista, M., Ippolito, C., Rizzo, M., Garrity, D., Cremisi, F., Pitto, L. (2018) Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish. Frontiers in cell and developmental biology. 6:58

D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60

Lindsay, H., Burger, A., Biyong, B., Felker, A., Hess, C., Zaugg, J., Chiavacci, E., Anders, C., Jinek, M., Mosimann, C., Robinson, M. D. (2016) CrispRVariants charts the mutation spectrum of genome engineering experiments. Nat. Biotechnol.. 34:701-702

Burger, A., Lindsay, H., Felker, A., Hess, C., Anders, C., Chiavacci, E., Zaugg, J., Weber, L.M., Catena, R., Jinek, M., Robinson, M.D., Mosimann, C. (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development (Cambridge, England). 143(11):2025-37

Chiavacci, E., D'Aurizio, R., Guzzolino, E., Russo, F., Baumgart, M., Groth, M., Mariani, L., D'Onofrio, M., Arisi, I., Pellegrini, M., Cellerino, A., Cremisi, F., Pitto, L. (2015) MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome. Scientific Reports. 5:18240

Chiavacci, E., Rizzo, M., Pitto, L., Patella, F., Evangelista, M., Mariani, L., Rainaldi, G. (2015) The zebrafish/tumor xenograft angiogenesis assay as a tool for screening anti-angiogenic miRNAs. Cytotechnology. 67(6):969-75

Agostini, S., Chiavacci, E., Matteucci, M., Torelli, M., Pitto, L., Lionetti, V. (2015) Barley beta-glucan promotes MnSOD expression and enhances angiogenesis under oxidative microenvironment. Journal of Cellular and Molecular Medicine. 19(1):227-38

Chiavacci, E., Cremisi, F., Guzzolino, E., Cellerino, A., Baumgart, M., D'aurizio, R., Pitto, L. (2014) miR-19a replacement rescues cardiac and fin defects in zebrafish model of Holt-Oram Syndrome. Cardiovascular research. 103 Suppl 1:S99

Patella, F., Leucci, E., Evangelista, M., Parker, B., Wen, J., Mercatanti, A., Rizzo, M., Chiavacci, E., Lund, A.H., Rainaldi, G. (2013) MiR-492 impairs the angiogenic potential of endothelial cells. Journal of Cellular and Molecular Medicine. 17(8):1006-1015

Chiavacci, E., Rizzo, M., Patella, F., Evangeslista, M., Mariani, L., Rainaldi, G., Pitto, L. (2013) miR-492 inhibits the angiogenesis in zebrafish (Danio rerio) model. European Heart Journal. 34:1055

Chiavacci, E., Dolfi, L., Verduci, L., Meghini, F., Gestri, G., Evangelista, A.M., Wilson, S.W., Cremisi, F., and Pitto, L. (2012) MicroRNA 218 Mediates the Effects of Tbx5a Over-Expression on Zebrafish Heart Development. PLoS One. 7(11):e50536

NON-ZEBRAFISH PUBLICATIONS
Chiavacci E, Bagnoli S, Cellerino A, Terzibasi Tozzini E (2023) Distribution of Brain-Derived Neurotrophic Factor in the Brain of the Small-Spotted Catshark Scyliorhinus canicula, and Evolution of Neurotrophins in Basal Vertebrates. Int. J. Mol. Sci. 2023, 24(11), 9495; https://doi.org/10.3390/ijms24119495

Bagnoli S, Chiavacci E, Cellerino A, Terzibasi Tozzini E (2023). Localization and Characterization of Major Neurogenic Niches in the Brain of the Lesser-Spotted Dogfish Scyliorhinus canicula. Int. J. Mol. Sci. 2023, 24(4), 3650; https://doi.org/10.3390/ijms24043650

Braga L, Ali H, Secco I, Chiavacci E, Neves G, Goldhill D, Penn R, Jimenez-Guardeno JM, Ortega-Prieto AM, Bussani R, Cannata A, Rizzari G, Collesi C, Schneider E, Arosio D, Shah AM, Barclay WS, Malim MH, Burrone J, Giacca M (2021). Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia. NATURE, vol. 594, p. 88-+, ISSN: 0028-0836, doi: 10.1038/s41586-021-03491-6 EA APR 2021

Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G (2017). Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes. SCIENTIFIC REPORTS, vol. 7, ISSN: 2045-2322, doi: 10.1038/s41598-017-10347-5

Gambacciani C, Kusmic C, Chiavacci E, Meghini F, Rizzo M, Mariani L, Pitto L (2014). miR-29a and miR-30c negatively regulate DNMT3a in cardiac ischemic tissues: Implications for cardiac remodelling. MICRORNA DIAGNOSTICS AND THERAPEUTICS, vol. 1, p. 35-45, ISSN: 2084-6843, doi: 10.2478/micrnat-2013-0004