ZFIN ID: ZDB-PERS-131009-2
Alexander, Matthew
Email: malexander@peds.uab.edu
URL: http://www.uab.edu/medicine/peds/research/division-research/pediatric-neurology-research/alexanderlab
Affiliation: Alexander Lab
Address: University of Alabama at Birmingham 1918 University Blvd. MCLM 407 Birmingham, AL 35294
Country: United States
Phone: 205-934-7790
Fax:
ORCID ID: 0000-0001-7406-5171


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Alexander, M.S., Hightower, R.M., Reid, A.L., Bennett, A.H., Iyer, L., Slonim, D.K., Saha, M., Kawahara, G., Kunkel, L.M., Kopin, A.S., Gupta, V.A., Kang, P.B., Draper, I. (2021) hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies. Muscle & nerve. 63(6):928-940
Hightower, R.M., Reid, A.L., Gibbs, D.E., Wang, Y., Widrick, J.J., Kunkel, L.M., Kastenschmidt, J.M., Villalta, S.A., van Groen, T., Chang, H., Gornisiewicz, S., Landesman, Y., Tamir, S., Alexander, M.S. (2019) The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice. Molecular therapy : the journal of the American Society of Gene Therapy. 28(1):189-201
Saha, M., Rizzo, S.A., Ramanathan, M., Hightower, R.M., Santostefano, K.E., Terada, N., Finkel, R.S., Berg, J.S., Chahin, N., Pacak, C.A., Wagner, R.E., Alexander, M.S., Draper, I., Kang, P.B. (2019) Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy. Human molecular genetics. 28:2365-2377
Widrick, J.J., Kawahara, G., Alexander, M.S., Beggs, A.H., Kunkel, L.M. (2019) Discovery of Novel Therapeutics for Muscular Dystrophies using Zebrafish Phenotypic Screens. Journal of neuromuscular diseases. 6(3):271-287
Serafini, P.R., Feyder, M.J., Hightower, R.M., Garcia-Perez, D., Vieira, N.M., Lek, A., Gibbs, D.E., Moukha-Chafiq, O., Augelli-Szafran, C.E., Kawahara, G., Widrick, J.J., Kunkel, L.M., Alexander, M.S. (2018) A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies. JCI insight. 3(18):
Ignatius, M.S., Hayes, M.N., Lobbardi, R., Chen, E.Y., McCarthy, K.M., Sreenivas, P., Motala, Z., Durbin, A.D., Molodtsov, A., Reeder, S., Jin, A., Sindiri, S., Beleyea, B.C., Bhere, D., Alexander, M.S., Shah, K., Keller, C., Linardic, C.M., Nielsen, P.G., Malkin, D., Khan, J., Langenau, D.M. (2017) The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Reports. 19:2304-2318
Vieira, N.M., Spinazzola, J.M., Alexander, M.S., Moreira, Y.B., Kawahara, G., Gibbs, D.E., Mead, L.C., Verjovski-Almeida, S., Zatz, M., Kunkel, L.M. (2017) Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 114(23):6080-6085
Widrick, J.J., Alexander, M., Sanchez, B., Gibbs, D., Kawahara, G., Beggs, A., Kunkel, L. (2016) Muscle dysfunction in a zebrafish model of Duchenne muscular dystrophy. Physiological Genomics. 48(11):850-860
Vieira, N.M., Elvers, I., Alexander, M.S., Moreira, Y.B., Eran, A., Gomes, J.P., Marshall, J.L., Karlsson, E.K., Verjovski-Almeida, S., Lindblad-Toh, K., Kunkel, L.M., Zatz, M. (2015) Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype. Cell. 163:1204-13
Alexander, M.S., Kawahara, G., Motohashi, N., Casar, J.C., Eisenberg, I., Myers, J.A., Gasperini, M.J., Estrella, E.A., Kho, A.T., Mitsuhashi, S., Shapiro, F., Kang, P.B., and Kunkel, L.M. (2013) MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation. Cell death and differentiation. 20(9):1194-208
Alexander, M.S., Kawahara, G., Kho, A.T., Howell, M.H., Pusack, T.J., Myers, J.A., Montanaro, F., Zon, L.I., Guyon, J.R., and Kunkel, L.M. (2011) Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors. Muscle & nerve. 43(5):741-750

NON-ZEBRAFISH PUBLICATIONS