ZFIN Person: Costagliola, Sabine

ZFIN ID: ZDB-PERS-130212-1

ZFIN ID: ZDB-PERS-130212-1

Costagliola, Sabine

Email:	scostag@ulb.ac.be
URL:	http://costalab.ulb.ac.be
Affiliation:	Costagliola Lab
Address:	IRIBHM, ULB 808 route de Lennik 1070 Brussels Belgium
Country:	Belgium
Phone:	+32 2 555 60 85
Fax:	+32 2 555 46 55
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Haerlingen, B., Opitz, R., Vandernoot, I., Molinaro, A., Shankar, M.P., Gillotay, P., Trubiroha, A., Costagliola, S. (2023) Mesodermal FGF and BMP govern the sequential stages of zebrafish thyroid specification. Development (Cambridge, England). 150(10):

Gillotay, P., Shankar, M., Haerlingen, B., Sema Elif, E., Pozo-Morales, M., Garteizgogeascoa, I., Reinhardt, S., Kränkel, A., Bläsche, J., Petzold, A., Ninov, N., Kesavan, G., Lange, C., Brand, M., Lefort, A., Libert, F., Detours, V., Costagliola, S., Singh, S.P. (2020) Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland. EMBO reports. 21(12):e50612

Vandernoot, I., Haerlingen, B., Gillotay, P., Trubiroha, A., Janssens, V., Opitz, R., Costagliola, S. (2020) Enhanced canonical Wnt signaling during early zebrafish development perturbs the interaction of cardiac mesoderm and pharyngeal endoderm and causes thyroid specification defects. Thyroid : official journal of the American Thyroid Association. 31(3):420-438

Duerinckx, S., Jacquemin, V., Drunat, S., Vial, Y., Passemard, S., Perazzolo, C., Massart, A., Soblet, J., Racapé, J., Desmyter, L., Badoer, C., Papadimitriou, S., Borgne, Y.L., Lefort, A., Libert, F., Maertelaer, V., Rooman, M., Costagliola, S., Verloes, A., Lenaerts, T., Pirson, I., Abramowicz, M. (2019) Digenic inheritance of human primary microcephaly delineates centrosomal and non centrosomal pathways. Human Mutation. 41(2):512-524

Giusti, N., Gillotay, P., Trubiroha, A., Opitz, R., Dumont, J.E., Costagliola, S., De Deken, X. (2019) Inhibition of the thyroid hormonogenic H₂O₂ production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound. Molecular and Cellular Endocrinology. 500:110635

Haerlingen, B., Opitz, R., Vandernoot, I., Trubiroha, A., Gillotay, P., Giusti, N., Costagliola, S. (2019) Small Molecule Screening in Zebrafish Embryos Identifies Signaling Pathways Regulating Early Thyroid Development. Thyroid : official journal of the American Thyroid Association. 29(11):1683-1703

Trubiroha, A., Gillotay, P., Giusti, N., Gacquer, D., Libert, F., Lefort, A., Haerlingen, B., De Deken, X., Opitz, R., Costagliola, S. (2018) A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Scientific Reports. 8:5647

Opitz, R., Hitz, M.P., Vandernoot, I., Trubiroha, A., Abu-Khudir, R., Samuels, M., Désilets, V., Costagliola, S., Andelfinger, G., Deladoëy, J. (2015) Functional Zebrafish Studies Based on Human Genotyping Point to Netrin-1 as a Link Between Aberrant Cardiovascular Development and Thyroid Dysgenesis. Endocrinology. 1(1):377-88

Opitz, R., Antonica, F., Costagliola, S. (2013) New Model Systems to Illuminate Thyroid Organogenesis. Part I: An Update on the Zebrafish Toolbox. European thyroid journal. 2:229-242

Opitz, R., Maquet, E., Zoenen, M., Dadhich, R., and Costagliola, S. (2011) TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish. Molecular endocrinology (Baltimore, Md.). 25(9):1579-99

NON-ZEBRAFISH PUBLICATIONS
Antonica F, Figini-Kasprzyk D, Opitz R, Iacovino M, Liao XH, Dumitrescu AM, Refetoff S, Peremans K, Manto M, Kyba M, Costagliola S.
Generation of functional thyroid from embryonic stem cells.
Nature. 2012 (491): 66-71

Zoenen M, Urizar E, Swillens S, Vassart G, Costagliola S.
Evidence for activity-regulated hormone-binding cooperativity across glycoprotein hormone receptor homomers. Nat Commun. 2012 Aug 14;3:1007.

Rodriguez W, Jin L, Janssens V, Pierreux C, Hick AC, Urizar E, Costagliola S.
Deletion of the RNaseIII enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations.
PLoS One. 2012;7(1):e29929.

Costagliola S.
Thyrotropin receptor activation by autoantibodies: a butterfly effect.
Ann Endocrinol (Paris). 2011 Apr;72(2):114-6.

Vassart G, Costagliola S.
G protein-coupled receptors: mutations and endocrine diseases.
Nat Rev Endocrinol. 2011 Jun;7(6):362-72.

Dieterich M, Bolz M, Reimer T, Costagliola S, Gerber B.
Two different entities of spontaneous ovarian hyperstimulation in a woman with FSH receptor mutation.
Reprod Biomed Online. 2010 Jun;20(6):751-8.

Tiotiu D, Alvaro Mercadal B, Imbert R, Verbist J, Demeestere I, De Leener A, Englert Y, Vassart G, Costagliola S, Delbaere A. Variants of the BMP15 gene in a cohort of patients with premature ovarian failure.
Hum Reprod. 2010 Jun;25(6):1581-7.

Maquet E, Costagliola S, Parma J, Christophe-Hobertus C, Oligny LL, Fournet JC, Robitaille Y, Vuissoz JM, Payot A, Laberge S, Vassart G, Van Vliet G, Delado�y J.
Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene.
J Clin Endocrinol Metab. 2009 Jan;94(1):197-203.

Costagliola S, De Leener A.
[Molecular mechanisms selected by evolution in primates for self-protection against human chorionic gonadotropin]. Bull Mem Acad R Med Belg. 2008;163(10-12):481-4;

Caltabiano G, Campillo M, De Leener A, Smits G, Vassart G, Costagliola S, Pardo L.
The specificity of binding of glycoprotein hormones to their receptors.
Cell Mol Life Sci. 2008 Aug;65(16):2484-92.

De Leener A, Caltabiano G, Erkan S, Idil M, Vassart G, Pardo L, Costagliola S.
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.
Hum Mutat. 2008 Jan;29(1):91-8.

Akcurin S, Turkkahraman D, Tysoe C, Ellard S, De Leener A, Vassart G, Costagliola S.
A family with a novel TSH receptor activating germline mutation (p.Ala485Val).
Eur J Pediatr. 2008 Nov;167(11):1231-7. Epub 2008 Jan 4.

Delbaere A, Smits G, Vassart G, Costagliola S.
Genetic predictors of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization.
Nat Clin Pract Endocrinol Metab. 2006 Nov;2(11):590-1.

Bonomi M, Busnelli M, Persani L, Vassart G, Costagliola S.
Structural differences in the hinge region of the glycoprotein hormone receptors: evidence from the sulfated tyrosine residues.
Mol Endocrinol. 2006 Dec;20(12):3351-63. Epub 2006 Aug 10.

De Leener A, Montanelli L, Van Durme J, Chae H, Smits G, Vassart G,
Costagliola S.
Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.
J Clin Endocrinol Metab. 2006 Feb;91(2):555-62. Epub 2005 Nov 8.

Costagliola S, Urizar E, Mendive F, Vassart G.
Specificity and promiscuity of gonadotropin receptors.
Reproduction. 2005 Sep;130(3):275-81. Review.

Urizar E, Montanelli L, Loy T, Bonomi M, Swillens S, Gales C, Bouvier M, Smits
G, Vassart G, Costagliola S.
Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.
EMBO J. 2005 Jun 1;24(11):1954-64.

Costagliola S, Bonomi M, Morgenthaler NG, Van Durme J, Panneels V, Refetoff S,
Vassart G.
Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.
Mol Endocrinol. 2004 Dec;18(12):3020-34.

Montanelli L, Van Durme JJ, Smits G, Bonomi M, Rodien P, Devor EJ,
Moffat-Wilson K, Pardo L, Vassart G, Costagliola S.
Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor.
Mol Endocrinol. 2004 Aug;18(8):2061-73.

Montanelli L, Delbaere A, Di Carlo C, Nappi C, Smits G, Vassart G,
Costagliola S.
A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.
J Clin Endocrinol Metab. 2004 Apr;89(4):1255-8.

Vassart G, Pardo L, Costagliola S.
A molecular dissection of the glycoprotein hormone receptors.
Trends Biochem Sci. 2004 Mar;29(3):119-26. Review.

Montanelli L, Delbaere A, Di Carlo C, Nappi C, Smits G, Vassart G,
Costagliola S.
A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.
J Clin Endocrinol Metab. 2004 Apr;89(4):1255-8.

Delbaere A, Smits G, Olatunbosun O, Pierson R, Vassart G, Costagliola S.
New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?
Hum Reprod. 2004 Mar;19(3):486-9. . Review.

Vassart G, Costagliola S.
A physiological role for the posttranslational cleavage of the thyrotropin receptor?
Endocrinology. 2004 Jan;145(1):1-3. Review..

Smits G, Olatunbosun O, Delbaere A, Pierson R, Vassart G, Costagliola S.
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.
N Engl J Med. 2003 Aug 21;349(8):760-6..

Smits G, Campillo M, Govaerts C, Janssens V, Richter C, Vassart G, Pardo L,
Costagliola S.
Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity.
EMBO J. 2003 Jun 2;22(11):2692-703.

Rodien P, Ho SC, Vlaeminck V, Vassart G, Costagliola S.
Activating mutations of TSH receptor.
Ann Endocrinol (Paris). 2003 Feb;64(1):12-6. Review.

Costagliola S, Vassart G.
Monoclonal antibodies with thyroid stimulating activity, at last.
Thyroid. 2002 Dec;12(12):1039-41. Review..

Costagliola S, Franssen JD, Bonomi M, Urizar E, Willnich M, Bergmann A,
Vassart G.
Generation of a mouse monoclonal TSH receptor antibody with stimulating activity.
Biochem Biophys Res Commun. 2002 Dec 20;299(5):891-6.

Vlaeminck-Guillem V, Ho SC, Rodien P, Vassart G, Costagliola S.
Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist.
Mol Endocrinol. 2002 Apr;16(4):736-46.

Smits G, Govaerts C, Nubourgh I, Pardo L, Vassart G, Costagliola S.
Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG.
Mol Endocrinol. 2002 Apr;16(4):722-35.

Costagliola S, Panneels V, Bonomi M, Koch J, Many MC, Smits G, Vassart G.
Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.
EMBO J. 2002 Feb 15;21(4):504-13.

Cornelis S, Uttenweiler-Joseph S, Panneels V, Vassart G, Costagliola S.
Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor.
Biochemistry. 2001 Aug 21;40(33):9860-9.

Ho SC, Van Sande J, Lefort A, Vassart G, Costagliola S.
Effects of mutations involving the highly conserved S281HCC motif in the extracellular domain of the thyrotropin (TSH) receptor on TSH binding and constitutive activity.
Endocrinology. 2001 Jul;142(7):2760-7.

Chin HS, Chin DK, Morgenthaler NG, Vassart G, Costagliola S.
Rarity of anti- Na+/I- symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD).
J Clin Endocrinol Metab. 2000 Oct;85(10):3937-40.

Pohlenz J, Duprez L, Weiss RE, Vassart G, Refetoff S, Costagliola S.
Failure of membrane targeting causes the functional defect of two mutant sodium iodide symporters.
J Clin Endocrinol Metab. 2000 Jul;85(7):2366-9.

Costagliola S, Vassart G.
Comparison of human and porcine TSH receptors.
Thyroid. 2000 May;10(5):446-7. No abstract available.

Costagliola S, Many MC, Denef JF, Pohlenz J, Refetoff S, Vassart G.
Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.
J Clin Invest. 2000 Mar;105(6):803-11.

Costagliola S, Sunthorntepvarakul T, Migeotte I, Van Sande J, Kajava AM,
Refetoff S, Vassart G.
Structure-function relationships of two loss-of-function mutations of the thyrotropin receptor gene.
Thyroid. 1999 Oct;9(10):995-1000.

Costagliola S, Morgenthaler NG, Hoermann R, Badenhoop K, Struck J, Freitag D,
Poertl S, Wegl�hner W, Hollidt JM, Quadbeck B, Dumont JE, Schumm-Draeger PM,
Bergmann A, Mann K, Vassart G, Usadel KH.
Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease.
J Clin Endocrinol Metab. 1999 Jan;84(1):90-7.

Costagliola S, Khoo D, Vassart G.
Production of bioactive amino-terminal domain of the thyrotropin receptor via insertion in the plasma membrane by a glycosylphosphatidylinositol anchor.
FEBS Lett. 1998 Oct 9;436(3):427-33.

Costagliola S, Rodien P, Many MC, Ludgate M, Vassart G.
Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor.
J Immunol. 1998 Feb 1;160(3):1458-65.

Costagliola S, Many MC, Stalmans-Falys M, Vassart G, Ludgate M.
Transfer of thyroiditis, with syngeneic spleen cells sensitized with the human thyrotropin receptor, to naive BALB/c and NOD mice.
Endocrinology. 1996 Nov;137(11):4637-43.

Costagliola S, Many MC, Stalmans-Falys M, Vassart G, Ludgate M.
The autoimmune response induced by immunising female mice with recombinant human thyrotropin receptor varies with the genetic background.
Mol Cell Endocrinol. 1995 Dec 29;115(2):199-206.

Costagliola S, Many MC, Stalmans-Falys M, Tonacchera M, Vassart G, Ludgate M.
Recombinant thyrotropin receptor and the induction of autoimmune thyroid disease in BALB/c mice: a new animal model.
Endocrinology. 1994 Nov;135(5):2150-9.

Costagliola S, Alcalde L, Ruf J, Vassart G, Ludgate M.
Overexpression of the extracellular domain of the thyrotrophin receptor in bacteria; production of thyrotrophin-binding inhibiting immunoglobulins.
J Mol Endocrinol. 1994 Aug;13(1):11-21.

Costagliola S, Niccoli P, Carayon P.
Glycoprotein hormone isomorphism and assay discrepancy: the paradigm of luteinizing hormone (LH).
J Endocrinol Invest. 1994 Apr;17(4):291-9. Review. No abstract available.

Costagliola S, Alcalde L, Tonacchera M, Ruf J, Vassart G, Ludgate M.
Induction of thyrotropin receptor (TSH-R) autoantibodies and thyroiditis in mice immunised with the recombinant TSH-R.
Biochem Biophys Res Commun. 1994 Mar 15;199(2):1027-34.

Costagliola S, Swillens S, Niccoli P, Dumont JE, Vassart G, Ludgate M.
Binding assay for thyrotropin receptor autoantibodies using the recombinant receptor protein.
J Clin Endocrinol Metab. 1992 Dec;75(6):1540-4.