ZFIN Person: Anbalagan, Savani

ZFIN ID: ZDB-PERS-121217-1

ZFIN ID: ZDB-PERS-121217-1

Anbalagan, Savani

Email:	savanb@amu.edu.pl
URL:	https://tinyurl.com/gasocrine
Affiliation:	Anbalagan Lab
Address:	Principal Investigator, Institute of Molecular Biology & Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul. Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland
Country:	Poland
Phone:	+48618295905
Fax:
ORCID ID:	0000-0003-4839-9439

BIOGRAPHY AND RESEARCH INTERESTS

Savani Anbalagan received his Masters from SASTRA University in India. He did his PhD research in Prof. Maria Pia Longhese's group at Univ. of Milano-Bicocca (Italy) on mechanisms protecting telomeres using budding yeast. He was awarded his PhD degree in 2014. After his PhD, he moved to Israel for a post-doctoral fellowship (2013-2019) in Prof. Gil Levkowitz's group at the Weizmann Institute of Science (Israel). Using zebrafish as vertebrate model organism, he studied how glial pituicytes promote neurohypophyseal oxytocin content and the neurohypophyseal endothelial decision to form blood-brain barrier (BBB)-less permeable capillaries (Dev Cell 2018; Elife 2019). Currently, he is a principal investigator at the Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University (AMU) in Poznań, Poland. At AMU, he established the first zebrafish facility and continue to explore the role of glial pituicytes on neurohypophyseal neurovascular morphogenesis. He led the development of the zebrafish ligand-receptor atlas, a valuable resource for the zebrafish research community (iScience 2023) and he also proposed gasocrine signaling and oxygen gasoreceptors (Am J Physiol Endocrinol Metab. 2024).

OTHER ROLES
Member of thesis advisory committee of Ms. Ruchi Jain, doctoral student in Prof. Vladimir Korzh research group at IIMCB, Poland.

PUBLICATIONS

Chodkowski, M., Zielezinski, A., Anbalagan, S. (2023) A ligand-receptor interactome atlas of the zebrafish. iScience. 26:107309107309

Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973

Wysocka, E., Gonicka, A., Anbalagan, S. (2023) CRISPR-Cas9 F0 knockout approach using predesigned in vitro transcribed guide RNAs partially recapitulates Rx3 function in eye morphogenesis. Journal of genetics. 102:

Anbalagan, S., Blechman, J., Gliksberg, M., Gordon, L., Rotkopf, R., Dadosh, T., Shimoni, E., Levkowitz, G. (2020) Correction: Robo2 regulates synaptic oxytocin content by affecting actin dynamics. eLIFE. 9

Ribeiro, D., Nunes, A.R., Teles, M., Anbalagan, S., Blechman, J., Levkowitz, G., Oliveira, R.F. (2020) Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish. eLIFE. 9:

Nunes, A.R., Carreira, L., Anbalagan, S., Blechman, J., Levkowitz, G., Oliveira, R.F. (2020) Perceptual mechanisms of social affiliation in zebrafish. Scientific Reports. 10:3642

Ribeiro, D., Nunes, A.R., Gligsberg, M., Anbalagan, S., Levkowitz, G., Oliveira, R.F. (2020) Oxytocin receptor signaling modulates novelty recognition but not social preference in zebrafish. Journal of neuroendocrinology. 32(4):e12834

Anbalagan, S., Blechman, J., Gliksberg, M., Gordon, L., Rotkopf, R., Dadosh, T., Shimoni, E., Levkowitz, G. (2019) Robo2 regulates synaptic oxytocin content by affecting actin dynamics. eLIFE. 8

Anbalagan, S., Gordon, L., Blechman, J., Matsuoka, R.L., Rajamannar, P., Wircer, E., Biran, J., Reuveny, A., Leshkowitz, D., Stainier, D.Y.R., Levkowitz, G. (2018) Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces. Developmental Cell. 47(6):711-726.e5

Blechman, J., Anbalagan, S., Matthews, G.G., Levkowitz, G. (2018) Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin. Frontiers in cell and developmental biology. 6:117

NON-ZEBRAFISH PUBLICATIONS
Anbalagan, S. (2021) Endocrine cross-talk between the gut microbiome and glial cells in development and disease. J Neuroendocrinol. 2021 May;33(5):e12924. doi: 10.1111/jne.12924.
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Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends.
Bonetti D, Anbalagan S, Lucchini G, Clerici M, Longhese MP.
EMBO J. 2013 Jan 23;32(2):275-89. doi: 10.1038/emboj.2012.327. Epub 2012 Dec

The role of shelterin in maintaining telomere integrity.
Longhese MP, Anbalagan S, Martina M, Bonetti D.
Front Biosci (Landmark Ed). 2012 Jan 1;17:1715-28. Review.

Rif1 supports the function of the CST complex in yeast telomere capping.
Anbalagan S, Bonetti D, Lucchini G, Longhese MP.
PLoS Genet. 2011 Mar;7(3):e1002024. doi: 10.1371/journal.pgen.1002024. Epub 2011 Mar 17.

Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres.
Bonetti D, Clerici M, Anbalagan S, Martina M, Lucchini G, Longhese MP.
PLoS Genet. 2010 May 27;6(5):e1000966. doi: 10.1371/journal.pgen.1000966.