ZFIN ID: ZDB-PERS-121108-2
Zolessi, Flavio
Email: fzolessi@fcien.edu.uy
URL: http://bcelular.fcien.edu.uy/investigacion/cell-biology-of-neural-development
Affiliation: Cell Biology of Neural Development
Address: Seccion Biologia Celular, Piso 7 Facultad de Ciencias, Universidad de la Republica Calle Igua 4225 Montevideo, 11400 Uruguay AND Cell Biology of Neural Development Lab Institut Pasteur de Montevideo Mataojo 2020 Montevideo, 11400 Uruguay
Country: Uruguay
Phone: +598 2525 8618 ext. 7144
Fax: +598 2525 8629
ORCID ID: 0000-0003-2405-994X


BIOGRAPHY AND RESEARCH INTERESTS
Our general research interest is centered on understanding the mechanisms of neural differentiation, both in normal and pathological situations. In particular, the main focus is on understanding cell polarity transitions that occur through the different stages of neural development in vertebrates, from neurulation to neuronal differentiation, mostly using zebrafish and chick as experimental systems.


PUBLICATIONS
Davison, C., Zolessi, F.R. (2021) Slit2 is necessary for optic axon organization in the zebrafish ventral midline. Cells & development. 166:203677
Aparicio, G., Rodao, M., Badano, J.L., Zolessi, F.R. (2021) Photoreceptor progenitor dynamics in the zebrafish embryo retina and its modulation by primary cilia and N-cadherin. The International journal of developmental biology. 65:439-455
Lepanto, P., Zolessi, F.R., Badano, J.L. (2019) Chapter 5 - Studying Human Genetic Variation in Zebrafish. En: Cellular and Animal Models in Human Genomics Research (Translational and Applied Genomics Series). Elsevier Science. :89-117
Paravani, E.V., Simoniello, M.F., Poletta, G.L., Zolessi, F.R., Casco, V.H. (2018) Cypermethrin: Oxidative stress and genotoxicity in retinal cells of the adult zebrafish. Mutation research. 826:25-32
Álvarez, G., Perdomo, C., Coronel, C., Aguilera, E., Varela, J., Aparicio, G., Zolessi, F.R., Cabrera, N., Vega, C., Rolón, M., Rojas de Arias, A., Pérez-Montfort, R., Cerecetto, H., González, M. (2017) Multi-Anti-Parasitic Activity of Arylidene Ketones and Thiazolidene Hydrazines against Trypanosoma cruzi and Leishmania spp. Molecules. 22(5)
Prieto, D., Zolessi, F.R. (2017) Functional Diversification of the Four MARCKS Family Members in Zebrafish Neural Development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(1-2):119-138
Lepanto, P., Davison, C., Casanova, G., Badano, J.L., Zolessi, F.R. (2016) Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish. Neural Development. 11:10
Prieto, D., Aparicio, G., Machado, M., Zolessi, F.R. (2015) Application of the DNA-Specific Stain Methyl Green in the Fluorescent Labeling of Embryos. Journal of visualized experiments : JoVE. (99):e52769
Paolini, A., Duchemin, A.L., Albadri, S., Patzel, E., Bornhorst, D., González Avalos, P., Lemke, S., Machate, A., Brand, M., Sel, S., Di Donato, V., Del Bene, F., Zolessi, F.R., Ramialison, M., Poggi, L. (2015) Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Development (Cambridge, England). 142(5):832-9
Prieto, D., Aparicio, G., Morande, P.E., Zolessi, F.R. (2014) A fast, low cost, and highly efficient fluorescent DNA labeling method using methyl green. Histochemistry and cell biology. 142:335-345
Randlett, O., Poggi, L., Zolessi, F.R., and Harris, W.A. (2011) The oriented emergence of axons from retinal ganglion cells is directed by laminin contact in vivo. Neuron. 70(2):266-280
Zolessi, F.R., Poggi, L., Wilkinson, C.J., Chien, C.B., and Harris, W.A. (2006) Polarization and orientation of retinal ganglion cells in vivo. Neural Development. 1:2

NON-ZEBRAFISH PUBLICATIONS
Lupo G, Piper M, Zolessi FR (2021) Editorial: Context-dependent regulation of neurogenesis: common themes and unique features of the neurogenic process in different model systems. Front. Cell Dev. Biol. 9:678475. doi: 10.3389/fcell.2021.678475.

Zolessi FR, Berois N, Brauer MM, Castillo E (2021) Building the embryo of developmental biology in Uruguay. Intl J Devl Biol 65: 71 - 76. doi: 10.1387/ijdb.200141fz

Aparicio G, Arruti C, Zolessi FR (2018) MARCKS phosphorylation by PKC strongly impairs cell polarity in the chick neural plate. Genesis 56(4): e23104. doi: 10.1002/dvg.23104.

Lepanto P, Badano JL, Zolessi FR* (2016) Neuron’s little helper: the role of primary cilia in neurogenesis. Neurogenesis. 3:1, e1253363. Review. doi: 10.1080/23262133.2016.1253363.

Zolessi FR (2016) Vertebrate neurogenesis: cell polarity (v. 3). Encyclopedia of Life Sciences (Wiley). DOI: 10.1002/9780470015902.a0000826.pub3.

Tinoco L.W., Fraga J.L., AnoBom C.D., Zolessi F.R., Obal G., Toledo A., Pritsch O., Arruti C. (2014) Structural characterization of a neuroblast-specific phosphorylated region of MARCKS. Biochim Biophys Acta 1844(4): 837-849.

Toledo A., Zolessi F.R., Arruti C. (2013) A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLOS ONE 8(4): e62863.

Ruiz-Perera L.M., Arruti C., Zolessi F.R. (2013) Early phosphorylation of MARCKS at Ser25 in migrating precursor cells and differentiating peripheral neurons. Neurosci. Lett. 544: 5-9.

Zolessi F.R., Arruti C. (2004) MARCKS in advanced stages of neural retina histogenesis. Dev. Neurosci. 26: 371-379.

Zolessi F.R., Durán R., Engström U., Cerveñansky C., Hellman U., Arruti C. (2004) Identification of the chicken MARCKS phosphorylation site specific for differentiating neurons as Ser 25 using a monoclonal antibody and mass spectrometry. J. Proteome Res. 3: 84-90.

Zolessi F.R., Arruti C. (2001) Sustained phosphorylation of MARCKS in differentiating neurogenic regions during chick embryo development. Brain Res. Dev. Brain Res. 130: 257-267.

Zolessi F.R., Arruti C. (2001) Apical accumulation of MARCKS in neural plate cells during neurulation in the chick embryo. BMC Dev. Biol. 1: 7.

Zolessi F.R., Hellman U., Baz A., Arruti C. (1999) Characterization of MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) identified by a monoclonal antibody generated against chick embryo neural retina. Biochem. Biophys. Res. Commun. 257: 480-487.