ZFIN Person: van Ham, Tjakko

ZFIN ID: ZDB-PERS-120220-1

ZFIN ID: ZDB-PERS-120220-1

van Ham, Tjakko

Email:	t.vanham@erasmusmc.nl
URL:	http://www.erasmusmc.nl/klinische_genetica/research/intro/?lang=en
Affiliation:	van Ham Lab
Address:	Erasmus MC Dept. of Clinical Genetics Faculty building, P.O. Box 2040 3000 CA, Rotterdam
Country:	Netherlands
Phone:	+31614737671
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Ruijmbeek, C.W., Housley, F., Idrees, H., Housley, M.P., Pestel, J., Keller, L., Lai, J.K.H., van der Linde, H.C., Willemsen, R., Piesker, J., Al-Hassnan, Z.N., Almesned, A., Dalinghaus, M., van den Bersselaar, L.M., van Slegtenhorst, M.A., Tessadori, F., Bakkers, J., van Ham, T.J., Stainier, D.Y., Verhagen, J.M., Reischauer, S. (2023) Bi-allelic variants in FLII cause pediatric cardiomyopathy by disrupting cardiomyocyte cell adhesion and myofibril organization. JCI insight. 8(17):

Deng, R., Medico-Salsench, E., Nikoncuk, A., Ramakrishnan, R., Lanko, K., Kühn, N.A., van der Linde, H.C., Lor-Zade, S., Albuainain, F., Shi, Y., Yousefi, S., Capo, I., van den Herik, E.M., van Slegtenhorst, M., van Minkelen, R., Geeven, G., Mulder, M.T., Ruijter, G.J.G., Lütjohann, D., Jacobs, E.H., Houlden, H., Pagnamenta, A.T., Metcalfe, K., Jackson, A., Banka, S., De Simone, L., Schwaede, A., Kuntz, N., Palculict, T.B., Abbas, S., Umair, M., AlMuhaizea, M., Colak, D., AlQudairy, H., Alsagob, M., Pereira, C., Trunzo, R., Karageorgou, V., Bertoli-Avella, A.M., Bauer, P., Bouman, A., Hoefsloot, L.H., van Ham, T.J., Issa, M., Zaki, M.S., Gleeson, J.G., Willemsen, R., Kaya, N., Arold, S.T., Maroofian, R., Sanderson, L.E., Barakat, T.S. (2023) AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Acta Neuropathologica. 146(2):353-368

Djannatian, M., Radha, S., Weikert, U., Safaiyan, S., Wrede, C., Deichsel, C., Kislinger, G., Rhomberg, A., Ruhwedel, T., Campbell, D.S., van Ham, T., Schmid, B., Hegermann, J., Möbius, W., Schifferer, M., Simons, M. (2023) Myelination generates aberrant ultrastructure that is resolved by microglia. The Journal of cell biology. 222(3):

Berdowski, W.M., van der Linde, H.C., Breur, M., Oosterhof, N., Beerepoot, S., Sanderson, L., Wijnands, L.I., de Jong, P., Tsai-Meu-Chong, E., de Valk, W., de Witte, M., van IJcken, W.F.J., Demmers, J., van der Knaap, M.S., Bugiani, M., Wolf, N.I., van Ham, T.J. (2022) Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy. Acta Neuropathologica. 144(2):211-239

Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488

Riemslagh, F.W., Verhagen, R.F.M., van der Toorn, E.C., Smits, D.J., Quint, W.H., van der Linde, H.C., van Ham, T.J., Willemsen, R. (2021) Reduction of oxidative stress suppresses poly-GR mediated toxicity in zebrafish embryos. Disease models & mechanisms. 14(11):

Yousefi, S., Deng, R., Lanko, K., Salsench, E.M., Nikoncuk, A., van der Linde, H.C., Perenthaler, E., van Ham, T.J., Mulugeta, E., Barakat, T.S. (2021) Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance. Genome Medicine. 13:162

Berdowski, W.M., Sanderson, L.E., van Ham, T.J. (2021) The multicellular interplay of microglia in health and disease: lessons from leukodystrophy. Disease models & mechanisms. 14(8)

Sofou, K., Meier, K., Sanderson, L.E., Kaminski, D., Montoliu-Gaya, L., Samuelsson, E., Blomqvist, M., Agholme, L., Gärtner, J., Mühlhausen, C., Darin, N., Barakat, T.S., Schlotawa, L., van Ham, T., Asin Cayuela, J., Sterky, F.H. (2021) Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like disease. EMBO Molecular Medicine. 13(5):e13376

Sanderson, L.E., Lanko, K., Alsagob, M., Almass, R., Al-Ahmadi, N., Najafi, M., Al-Muhaizea, M.A., Alzaidan, H., AlDhalaan, H., Perenthaler, E., van der Linde, H.C., Nikoncuk, A., Kühn, N.A., Antony, D., Owaidah, T.M., Raskin, S., Vieira, L.G.D.R., Mombach, R., Ahangari, N., Silveira, T.R.D., Ameziane, N., Rolfs, A., Alharbi, A., Sabbagh, R.M., AlAhmadi, K., Alawam, B., Ghebeh, H., AlHargan, A., Albader, A.A., Binhumaid, F.S., Goljan, E., Monies, D., Mustafa, O.M., Aldosary, M., AlBakheet, A., Alyounes, B., Almutairi, F., Al-Odaib, A., Aksoy, D.B., Basak, A.N., Palvadeau, R., Trabzuni, D., Rosenfeld, J.A., Karimiani, E.G., Meyer, B.F., Karakas, B., Al-Mohanna, F., Arold, S.T., Colak, D., Maroofian, R., Houlden, H., Bertoli-Avella, A.M., Schmidts, M., Barakat, T.S., van Ham, T.J., Kaya, N. (2021) Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking. Brain : a journal of neurology. 144(3):769-780

Van Dyck, A., Bollaerts, I., Beckers, A., Vanhunsel, S., Glorian, N., van Houcke, J., van Ham, T.J., De Groef, L., Andries, L., Moons, L. (2021) Müller glia-myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish. Glia. 69(6):1444-1463

Cunha, M.I., Su, M., Cantuti-Castelvetri, L., Müller, S.A., Schifferer, M., Djannatian, M., Alexopoulos, I., van der Meer, F., Winkler, A., van Ham, T.J., Schmid, B., Lichtenthaler, S.F., Stadelmann, C., Simons, M. (2020) Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. The Journal of experimental medicine. 217(5):

Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Kuil, L.E., van Ham, T.J., Zagury, J.F., Sieger, D. (2019) Gene expression profiling reveals a conserved microglia signature in larval zebrafish. Glia. 68(2):298-315

Verhagen, J.M.A., van den Born, M., van der Linde, H.C., Nikkels, P.G.J., Verdijk, R.M., Kivlen, M.H., van Unen, L.M.A., Baas, A.F., Ter Heide, H., van Osch-Gevers, L., Hoogeveen-Westerveld, M., Herkert, J.C., Bertoli-Avella, A.M., van Slegtenhorst, M.A., Wessels, M.W., Verheijen, F.W., Hassel, D., Hofstra, R.M.W., Hegde, R.S., van Hasselt, P.M., van Ham, T.J., van de Laar, I.M.B.H. (2019) Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy. Circulation. Genomic and precision medicine. 12(9):397-406

Kuil, L.E., López Martí, A., Carreras Mascaro, A., van den Bosch, J.C., van den Berg, P., van der Linde, H.C., Schoonderwoerd, K., Ruijter, G.J.G., van Ham, T.J. (2019) Hexb enzyme deficiency leads to lysosomal abnormalities in radial glia and microglia in zebrafish brain development. Glia. 67(9):1705-1718

Oosterhof, N., Chang, I.J., Karimiani, E.G., Kuil, L.E., Jensen, D.M., Daza, R., Young, E., Astle, L., van der Linde, H.C., Shivaram, G.M., Demmers, J., Latimer, C.S., Keene, C.D., Loter, E., Maroofian, R., van Ham, T.J., Hevner, R.F., Bennett, J.T. (2019) Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia. American journal of human genetics. 104(5):936-947

Kuil, L.E., Oosterhof, N., Geurts, S.N., van der Linde, H.C., Meijering, E., van Ham, T.J. (2019) Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain. Disease models & mechanisms. 12(3):

Tsarouchas, T.M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N., Feng, Y., van Ham, T.J., Becker, T., Becker, C.G. (2018) Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration. Nature communications. 9:4670

Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6

Gui, H., Schriemer, D., Cheng, W.W., Chauhan, R.K., Antiňolo, G., Berrios, C., Bleda, M., Brooks, A.S., Brouwer, R.W., Burns, A.J., Cherny, S.S., Dopazo, J., Eggen, B.J., Griseri, P., Jalloh, B., Le, T.L., Lui, V.C., Luzón-Toro, B., Matera, I., Ngan, E.S., Pelet, A., Ruiz-Ferrer, M., Sham, P.C., Shepherd, I.T., So, M.T., Sribudiani, Y., Tang, C.S., van den Hout, M.C., van der Linde, H.C., van Ham, T.J., van IJcken, W.F., Verheij, J.B., Amiel, J., Borrego, S., Ceccherini, I., Chakravarti, A., Lyonnet, S., Tam, P.K., Garcia-Barceló, M.M., Hofstra, R.M. (2017) Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome biology. 18:48

Oosterhof, N., Kuil, L.E., van Ham, T.J. (2017) Microglial Activation by Genetically Targeted Conditional Neuronal Ablation in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 1559:377-390

Oosterhof, N., Holtman, I.R., Kuil, L.E., van der Linde, H.C., Boddeke, E.W., Eggen, B.J., van Ham, T.J. (2017) Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Glia. 65(1):138-149

Kuipers, J., Kalicharan, R.D., Wolters, A.H., van Ham, T.J., Giepmans, B.N. (2016) Large-scale Scanning Transmission Electron Microscopy (Nanotomy) of Healthy and Injured Zebrafish Brain. Journal of visualized experiments : JoVE. (111)

Oosterhof, N., Boddeke, E., van Ham, T.J. (2015) Immune cell dynamics in the CNS: Learning from the zebrafish. Glia. 63(5):719-35

van Ham, T.J., Brady, C.A., Kalicharan, R.D., Oosterhof, N., Kuipers, J., Veenstra-Algra, A., Sjollema, K.A., Peterson, R.T., Kampinga, H.H., Giepmans, B.N. (2014) Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation. Disease models & mechanisms. 7:857-869

Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843

van Ham, T.J., Kokel, D., and Peterson, R.T. (2012) Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment. Current biology : CB. 22(9):830-836

van Ham, T.J., Mapes, J., Kokel, D., and Peterson, R.T. (2010) Live imaging of apoptotic cells in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(11):4336-4342

NON-ZEBRAFISH PUBLICATIONS
Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ. A Small Molecule that
Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Rep. 2015 Dec 1;13(9):2027-36. doi: 10.1016/j.celrep.2015.10.042.

Kuipers J, van Ham TJ, Kalicharan RD, Veenstra-Algra A, Sjollema KA, Dijk F,Schnell U, Giepmans BN. FLIPPER, a combinatorial probe for correlated live
imaging and electron microscopy, allows identification and quantitative analysis of various cells and organelles. Cell Tissue Res. 2015 Apr;360(1):61-70. doi:10.1007/s00441-015-2142-7.

Kaminski Schierle GS, Bertoncini CW, Chan FT, van der Goot AT, Schwedler S, Skepper J, Schlachter S, van Ham T, Esposito A, Kumita JR, Nollen EA, Dobson CM, Kaminski CF. (2011) A FRET sensor for non-invasive imaging of amyloid formation in vivo. Chemphyschem. Feb 25;12(3):673-80. Epub 2011 Feb 9.

van Ham TJ, Holmberg M, Teuling E, van der Goot AT, Thijssen KL, van Bergeijk P, Nollen EA. (2010) Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell. Aug 20;142(4):601-612.

van Ham TJ, Esposito A, Kumita JR, Hsu ST, Kaminski Schierle GS, Kaminski CF, Dobson CM, Nollen EA, Bertoncini CW. (2009) Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. J Mol Biol. Nov 3;395, 627-642.

Roodveldt C, Bertoncini CW, Andersson A, van der Goot AT, Hsu ST, Fern�ndez-Montesinos R, de Jong J, van Ham TJ, Nollen EA, Pozo D, Christodoulou J, Dobson CM. (2009) Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO J. Dec 2;28(23):3758-70.

van Ham TJ, Breitling R, Swertz MA, Nollen EA. (2009) Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Molecular Medicine. Review, 8-9, 360-370

van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterk RH, Nollen EA. (2008) C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet. Mar 21;4(3):e1000027.

van Ham TJ and Nollen EAA. (2011) Caenorhabditis elegans as a Model Organism for Dementia, Animals modles of dementia, Peter Paul De Deyn and Debby Van Dam (eds.), Animal Models of Dementia, Neuromethods, 2011, Volume 48, Part 4, 241-253