ZFIN Person: Sinha, Indrajit

ZFIN ID: ZDB-PERS-120109-1

ZFIN ID: ZDB-PERS-120109-1

Sinha, Indrajit

Email:	indrajit.sinha@acenzia.com
URL:	http://www.acenzia.com
Affiliation:
Address:	Acenzia Inc. Tecumseh, Ontario, Canada
Country:
Phone:	+1(519) 737-0470
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

My personal motivation is in improving people’s lives by utilizing proven but unused technology.

PUBLICATIONS

Crozier, M., Tubman, J., Fifield, B.A., Ferraiuolo, R.M., Ritchie, J., Zuccato, K., Mailloux, E., Sinha, I., Hamm, C., Porter, L.A. (2022) Frequently used antiemetic agent dexamethasone enhances the metastatic behaviour of select breast cancer cells. PLoS One. 17:e0274675

Jakhar, R., Luijten, M.N.H., Wong, A.X.F., Cheng, B., Guo, K., Neo, S.P., Au, B., Kulkarni, M., Lim, K.J., Maimaiti, J., Chong, H.C., Lim, E.H., Tan, T.B.K., Ong, K.W., Sim, Y., Wong, J.S.L., Khoo, J.B.K., Ho, J.T.S., Chua, B.T., Sinha, I., Wang, X., Connolly, J.E., Gunaratne, J., Crasta, K.C. (2018) Autophagy Governs Protumorigenic Effects of Mitotic Slippage-induced Senescence. Molecular cancer research : MCR. 16:1625-1640

Ferraiuolo, R.M., Tubman, J., Sinha, I., Hamm, C., Porter, L.A. (2017) The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance. Oncotarget. 8:23337-23352

Tan, D.S., Haaland, B., Gan, J.M., Tham, S.C., Sinha, I., Tan, E.H., Lim, K.H., Takano, A., Krisna, S.S., Thu, M.M., Liew, H.P., Ullrich, A., Lim, W.T., and Chua, B.T. (2014) Bosutinib inhibits migration and invasion via ack1 in kras mutant non-small cell lung cancer. Molecular Cancer. 13(1):13

NON-ZEBRAFISH PUBLICATIONS
1. Ahmed, N., Zeng, M., Sinha, I., Polin, L., Wei W-Z., Rathinam, C., Flavell, R., Massoumi, R. & Venuprasad, K. (2011) The E3 ligase Itch and deubiquitinase Cyld act together to regulate inflammation. Nat. Immunol. (Advanced Online Publication)

2. *Benchaala, I., *Sinha, I., *Wykes, S., Hali, M., Mishra, M. Kotta, K., Kannan, R.M. & J. Whittum-Hudson. (2009) Targeted delivery of nanodevices to Chlamydia trachomatis infected tissues in murine reactive arthritis. Arthrit. Rheum. 60: 10. (*equal contributors)

3. Mishra, M.K., Kotta, K., Benchaala, I., Wykes, S., Hali, M., Sinha, I., Whittum-Hudson, J. & Kannan, R.M. (2009) Development of PAMAM-dendrimer based nanodevices for targeted delivery to Chlamydia trachomatis infection. Polym. Mat. Sci. Eng. 100: 09.

4. Zhang, T., Nirantar, S., Lim, H.H., Sinha, I. & Surana, U. (2009) DNA damage checkpoint maintains Cdh1 in an active state to inhibit anaphase progression. Dev. Cell 17: 541-551.

5. Sinha, I., Wang, Y.M., Philp, R., Li, C.R., Yap, W.H. & Wang, Y. (2007) Cyclindependent kinases control septin phosphorylation in Candida albicans hyphal development. Dev. Cell 13: 421-432.

6. Sinha, I. & Dick, T. (2004) Role of malonyl coenzyme A: Acyl carrier protein transacylase (MCAT) in the growth-inhibitory effect of the calmodulin antagonist trifluoperazine in Mycobacterium bovis BCG. J. Antimicrob. Chemother. 53: 1072-1075.

7. Sinha, I., Boon, C. & Dick, T. (2003) Apparent growth phase-dependent phosphorylation of malonyl coenzyme A: Acyl carrier protein transacylase (MCAT), a major fatty acid synthase II component in Mycobacterium bovis BCG. FEMS Microbiol. Lett. 227: 141-147.

8. Virdi, J.S., Sinha, I., Rajendran P. & Singh I. (2001) Arsenite-induced multiple antibiotic resistance phenotypes in environmental isolates of Yersinia enterocolitica. Current Microbiology 43: 144-146.

9. Sinha, I. & Virdi, J. S. (2000) Differentiation of non-pathogenic (biotype 1A) Yersinia enterocolitica from pathogenic bioserotypes by sodium acetate utilization. Journal of Medical Microbiology 49: 674-676.

10. Bansal, N., Sinha, I. & Virdi, J.S. (2000) Virulence plasmid (pYV)-associated susceptibility of Yersinia enterocolitica to chlorine and heavy metals. Journal of Applied Microbiology 89: 663-667.

11. Bansal, N., Sinha, I. & Virdi, J.S. (2000) Arsenic and cadmium resistance in environmental isolates of Yersinia enterocolitica and Yersinia intermedia. Canadian Journal of Microbiology 46: 481-484.

12. Sinha, I. & Virdi, J.S. (2000) In vitro antibiotic susceptibilities of Yersinia enterocolitica and Yersinia intermedia isolated from sewage effluents. Current Science 79: 90-92.

13. Sinha, I. & Virdi, J.S. (2000) Isolation of Yersinia enterocolitica and Yersinia intermedia from wastewaters and their biochemical and serological characteristics. Current Science 2000, 79: 510-513.

14. Benchaala, I., Sinha, I., Hali, M., Gerard, H., Bharatwaj, B, Hudson., A., Rocha, S. and Whittum-Hudson, J. (2011). Reduction in Chlamydia trachomatis-associated murine reactive arthritis by novel peptide vaccine candidates. Oral presentation at ACR/ARHP Scientific meeting 11, Chicago, USA, Nov 5-9.

15. Whittum-Hudson, J., Hali, M., Sinha, I., Bharatwaj, B., Oszust, C., Hudson, A. and da Rocha, S. (2011) Novel Mimotope Peptides as anti-chlamydial vaccine candidates. Poster presentation at 15th International Congress of Mucosal Immunology, Paris, France, July 5-9.

16. Peng, D.J., Sinha, I., Zeng, M., Subramaniam, M., Spelsberg, T.C. and Venuprasad, K. (2010) Non-canonical K-27 linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth. Poster presentation at 39th Autumn Immunology Conference, Chicago, IL, USA, Nov. 19-22.

17. Bonneau, P., Macpharlin, C., Hali, M., Benchaala, I., Sinha, I., Kannan, R., Mishra, M. and Whittum-Hudson, J. (2010). Characterizing Therapeutic Effects of Antibioticloaded Nanodevices in Chlamydial Infections. Medical student summer research symposium, Chemical Engineering & Materials Science, College of Engineering, Wayne State University, Detroit, USA.

18. Mishra, M.K., Kotta, K., Benchaala, I., Wykes, S.M., Hali, M., Sinha, I., Whittum-Hudson, J. and Kannan, R.M. (2009) Development of Folate-PAMAM and Azithromycin-PAMAM Nanodevices for Biodistribution, Imaging, Cellular Uptake, and Targeted Delivery to Chlamydial Infections. Poster presentation at AIChE Annual Meeting, Nashville, TN, USA, Nov. 8-13.

19. Benchaala, I., Sinha, I., Wykes, S.M., Hali, M., Mishra, M., Kotta, K., Kannan, R.M., Whittum-Hudson, J.A. (2009) Targeted delivery of Nanoparticles to Chlamydia trachomatis–infected tissues in murine reactive arthritis. Oral presentation at ACR/ARHP Scientific meeting 09, Philadelphia, Pennsylvania, USA, Oct 17-21.

20. Mishra, M.K., Kotta, K., Benchaala, I., Wykes, S., Hali, M., Sinha, I., Whittum-Hudson, J. and Kannan, R.M. (2009) Development of PAMAM-dendrimer based nanodevices for targeted delivery to Chlamydia trachomatis infection. Poster presentation at Nanoscience: Challenges for the Future: 237th ACS National Meeting & Exposition, Salt Lake City, UT, Mar. 22-26.

21. Sinha, I., Oszust, C., Sekhon, K., Wu, L. Hali, M., da Rocha, S., Hudson, A., Whittum-Hudson, J. (2009) Test of novel peptides as anti-chlamydial vaccine candidates. Oral presentation at CBRS 2009: 4th Biennial Meeting of the Chlamydia Basic Research Society, Little Rock, Arkansas, USA, Mar. 20-23.

22. Whittum-Hudson, J., Benchaala, I., Wykes, S., Hali, M., Sinha, I., Mishra, M., Kotta, K., Kannan, R.M. (2009) Development of PAMAM-dendrimer based nanodevices for targeted delivery to Chlamydia trachomatis infection. Poster presentation at CBRS 2009: 4th Biennial Meeting of the Chlamydia Basic Research Society, Little Rock, Arkansas, USA, Mar. 20-23.

23. Sekhon, K., Wykes, S., Sovinski, A., Toti, U., Hali, M., Sinha, I., Gérard, H., Hudson, A., Panyam, J., Whittum-Hudson, J. (2009) Use of nanotechnology to target acutely and persistently Chlamydia-infected cells for therapy and imaging in vitro and in vivo. Poster presented at CBRS 2009: 4th Biennial Meeting of the Chlamydia Basic
Research Society, Little Rock, Arkansas, USA, Mar. 20-23.

24. Sinha, I., Wang, Y.M., Philp, R., Li, C.R., Yap, W.H. and Wang, Y. (2008) Septin phosphorylation in Candida albicans during hyphal development. ASM Conferences: 9th Candida and Candidiasis, Jersey City, NJ, USA, Mar. 24-28.

25. Sinha, I. and Dick, T. (2004) Role of malonyl coenzyme A: Acyl carrier protein transacylase (MCAT) in the growth-inhibitory effect of the calmodulin antagonist trifluoperazine in Mycobacterium bovis BCG. Oral presentation at NITD Inaugural Symposium on Dengue Fever and Tuberculosis, Singapore, Jul. 5-6.

26. Sinha, I., Boon, C. and Dick, T. (2003) Growth phase-dependent Proteome phosphorylation in Mycobacterium bovis BCG. Poster presentation at the 103rd ASM conference, Washington DC, USA, May. 2003.

27. Sinha, I., Boon, C. and Dick, T. (2003) Growth phase-dependent Proteome phosphorylation in Mycobacterium bovis BCG. Oral presentation at NITD Inaugural Symposium on Dengue Fever and Tuberculosis, Singapore, Jan. 22-23.

28. Sinha, I., Boon C., and Dick, T. (2002) Growth phase-independent proteome phosphorylation in Mycobacterium bovis BCG. Oral presentation at the Second International Conference on Structural Biology and Functional Genomics, Singapore, Dec. 2-4.

29. Sinha, I. and Virdi, J. S. (2000) Environmental Yersinia enterocolitica biotype 1A produce water-soluble siderophore(s) but lack yersiniophore. Oral presentation at 40th Annual Conference of AMI at Bhubaneswar, India. Jan. 22-24.