ZFIN Person: Tanaka, Toshio

ZFIN ID: ZDB-PERS-111104-1

ZFIN ID: ZDB-PERS-111104-1

Tanaka, Toshio

Email:	tanaka@doc.medic.mie-u.ac.jp
URL:
Affiliation:
Address:	Department of Molecular and Cellular Pharmacology Pharmacogenomics and Pharmacoinformatics Mie University Graduate School of Medicine Japan
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BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Higuchi, A., Wakai, E., Tada, T., Koiwa, J., Adachi, Y., Shiromizu, T., Goto, H., Tanaka, T., Nishimura, Y. (2021) Generation of a Transgenic Zebrafish Line for In Vivo Assessment of Hepatic Apoptosis. Pharmaceuticals (Basel, Switzerland). 14(11):

Okamoto, R., Goto, I., Nishimura, Y., Kobayashi, I., Hashizume, R., Yoshida, Y., Ito, R., Kobayashi, Y., Nishikawa, M., Ali, Y., Saito, S., Tanaka, T., Sawa, Y., Ito, M., Dohi, K. (2020) Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish. PLoS One. 15:e0240129

Yamanaka, M., Iwata, H., Masuda, K., Araki, M., Okuno, Y., Okamura, M., Koiwa, J., Tanaka, T. (2020) A novel orexin antagonist from a natural plant was discovered using zebrafish behavioural analysis. European review for medical and pharmacological sciences. 24:5127-5139

Ashikawa, Y., Shiromizu, T., Miura, K., Adachi, Y., Matsui, T., Bessho, Y., Tanaka, T., Nishimura, Y. (2019) C3orf70 Is Involved in Neural and Neurobehavioral Development. Pharmaceuticals (Basel, Switzerland). 12(4):

Koiwa, J., Shiromizu, T., Adachi, Y., Ikejiri, M., Nakatani, K., Tanaka, T., Nishimura, Y. (2019) Generation of a Triple-Transgenic Zebrafish Line for Assessment of Developmental Neurotoxicity during Neuronal Differentiation. Pharmaceuticals (Basel, Switzerland). 12(4):

Monma, Y., Shimada, Y., Nakayama, H., Zang, L., Nishimura, N., Tanaka, T. (2019) Aging-associated microstructural deterioration of vertebra in zebrafish. Bone reports. 11:100215

Yamashita, A., Deguchi, J., Honda, Y., Yamada, T., Miyawaki, I., Nishimura, Y., Tanaka, T. (2019) Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish. Journal of Pharmacological and Toxicological Methods. 96:34-45

Vranic, S., Shimada, Y., Ichihara, S., Kimata, M., Wu, W., Tanaka, T., Boland, S., Tran, L., Ichihara, G. (2019) Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test. International Journal of Molecular Sciences. 20(4)

Tanaka, T., Koiwa, J. (2019) [Next generation zebrafish-based drug discovery and precision medicine]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 154:78-83

Kasahara, K., Aoki, H., Kiyono, T., Wang, S., Kagiwada, H., Yuge, M., Tanaka, T., Nishimura, Y., Mizoguchi, A., Goshima, N., Inagaki, M. (2018) EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. Nature communications. 9:758

Matsubara, H., Matsui, Y., Miyata, R., Nishimura, Y., Yamamoto, T., Tanaka, T., Kondo, M. (2017) New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae. Documenta ophthalmologica. Advances in ophthalmology. 135(2):147-154

Ashikawa, Y., Nishimura, Y., Okabe, S., Sato, Y., Yuge, M., Tada, T., Miyao, H., Murakami, S., Kawaguchi, K., Sasagawa, S., Shimada, Y., Tanaka, T. (2017) Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Heliyon. 3:e00266

Ashikawa, Y., Nishimura, Y., Okabe, S., Sasagawa, S., Murakami, S., Yuge, M., Kawaguchi, K., Kawase, R., Tanaka, T. (2016) Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish. Frontiers in pharmacology. 7:206

Saito, Y., Tsuruma, K., Shimazawa, M., Nishimura, Y., Tanaka, T., Hara, H. (2016) Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish. Journal of Pharmacological Sciences. 131(3):215-8

Sasagawa, S., Nishimura, Y., Okabe, S., Murakami, S., Ashikawa, Y., Yuge, M., Kawaguchi, K., Kawase, R., Okamoto, R., Ito, M., Tanaka, T. (2016) Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy. Frontiers in pharmacology. 7:162

Sasagawa, S., Nishimura, Y., Sawada, H., Zhang, E., Okabe, S., Murakami, S., Ashikawa, Y., Yuge, M., Kawaguchi, K., Kawase, R., Mitani, Y., Maruyama, K., Tanaka, T. (2016) Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension. Frontiers in pharmacology. 7:142

Kawase, R., Nishimura, Y., Ashikawa, Y., Sasagawa, S., Murakami, S., Yuge, M., Okabe, S., Kawaguchi, K., Yamamoto, H., Moriyuki, K., Yamane, S., Tsuruma, K., Shimazawa, M., Hara, H., Tanaka, T. (2016) EP300 Protects from Light-Induced Retinopathy in Zebrafish. Frontiers in pharmacology. 7:126

Sasagawa, S., Nishimura, Y., Hayakawa, Y., Murakami, S., Ashikawa, Y., Yuge, M., Okabe, S., Kawaguchi, K., Kawase, R., Tanaka, T. (2016) E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish. Frontiers in pharmacology. 7:119

Zhang, B., Shimada, Y., Hirota, T., Ariyoshi, M., Kuroyanagi, J., Nishimura, Y., Tanaka, T. (2016) Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Translational research : the journal of laboratory and clinical medicine. 170:89-98.e3

Sasagawa, S., Nishimura, Y., Kon, T., Yamanaka, Y., Murakami, S., Ashikawa, Y., Yuge, M., Okabe, S., Kawaguchi, K., Kawase, R., Tanaka, T. (2016) DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina. Frontiers in pharmacology. 7:57

Sasagawa, S., Nishimura, Y., Koiwa, J., Nomoto, T., Shinto, T., Murakami, S., Yuge, M., Kawaguchi, K., Kawase, R., Miyazaki, T., Tanaka, T. (2016) In vivo detection of mitochondrial dysfunction induced by clinical drugs and disease-associated genes using a novel dye ZMJ214 in zebrafish. ACS Chemical Biology. 11(2):381-8

Nishimura, Y., Okabe, S., Sasagawa, S., Murakami, S., Ashikawa, Y., Yuge, M., Kawaguchi, K., Kawase, R., Tanaka, T. (2015) Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers. Frontiers in pharmacology. 6:257

Nishimura, Y., Sasagawa, S., Ariyoshi, M., Ichikawa, S., Shimada, Y., Kawaguchi, K., Kawase, R., Yamamoto, R., Uehara, T., Yanai, T., Takata, R., Tanaka, T. (2015) Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Frontiers in pharmacology. 6:199

Zang, L., Shimada, Y., Nishimura, Y., Tanaka, T., Nishimura, N. (2015) Repeated Blood Collection for Blood Tests in Adult Zebrafish. Journal of visualized experiments : JoVE. (102):e53272

Zhang, B., Shimada, Y., Kuroyanagi, J., Ariyoshi, M., Nomoto, T., Shintou, T., Umemoto, N., Nishimura, Y., Miyazaki, T., Tanaka, T. (2015) In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3). Biomaterials. 52:14-25

Shimada, Y., Kuninaga, S., Ariyoshi, M., Zhang, B., Shiina, Y., Takahashi, Y., Umemoto, N., Nishimura, Y., Enari, H., Tanaka, T. (2015) E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. Nutrition & metabolism. 12:17

Kuroyanagi, J., Shimada, Y., Zhang, B., Ariyoshi, M., Umemoto, N., Nishimura, Y., Tanaka, T. (2015) Corrigendum to "Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression" [FEBS Lett. 588 (2014) 3409-3416]. FEBS letters. 589:870

Chang, J., Ichihara, G., Shimada, Y., Tada-Oikawa, S., Kuroyanagi, J., Zhang, B., Suzuki, Y., Sehsah, R., Kato, M., Tanaka, T., Ichihara, S. (2015) Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis. Journal of nanoscience and nanotechnology. 15:2140-7

Nishimura, Y., Murakami, S., Ashikawa, Y., Sasagawa, S., Umemoto, N., Shimada, Y., Tanaka, T. (2015) Zebrafish as a systems toxicology model for developmental neurotoxicity testing. Congenital anomalies. 55(1):1-16

Kawabata, M., Umemoto, N., Shimada, Y., Nishimura, Y., Zhang, B., Kuroyanagi, J., Miyabe, M., Tanaka, T. (2015) Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 143(2):374-84

Zhang, B., Shimada, Y., Kuroyanagi, J., Nishimura, Y., Umemoto, N., Nomoto, T., Shintou, T., Miyazaki, T., Tanaka, T. (2014) Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 35(12):11861-9

Kuroyanagi, J., Shimada, Y., Zhang, B., Ariyoshi, M., Umemoto, N., Nishimura, Y., Tanaka, T. (2014) Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS letters. 588(18):3409-16

Shimada, Y., Kuroyanagi, J., Zhang, B., Ariyoshi, M., Umemoto, N., Nishimura, Y., and Tanaka, T. (2014) Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. International journal of obesity (2005). 38(8):1053-60

Zhang, B., Shimada, Y., Kuroyanagi, J., Umemoto, N., Nishimura, Y., and Tanaka, T. (2014) Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS One. 9(1):e85439

Hiramitsu, M., Shimada, Y., Kuroyanagi, J., Inoue, T., Katagiri, T., Zang, L., Nishimura, Y., Nishimura, N., and Tanaka, T. (2014) Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Scientific Reports. 4:3708

Shimada, Y., Nishimura, Y., Tanaka, T. (2014) Zebrafish-based systems pharmacology of cancer metastasis. Methods in molecular biology (Clifton, N.J.). 1165:223-38

Umemoto, N., Nishimura, Y., Shimada, Y., Yamanaka, Y., Kishi, S., Ito, S., Okamori, K., Nakamura, Y., Kuroyanagi, J., Zhang, Z., Zang, L., Wang, Z., Nishimura, N., and Tanaka, T. (2013) Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish. Molecular Biotechnology. 55(2):131-42

Zang, L., Shimada, Y., Nishimura, Y., Tanaka, T., and Nishimura, N. (2013) A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish. Zebrafish. 10(3):425-32

Nishimura, Y., Yata, K., Nomoto, T., Ogiwara, T., Watanabe, K., Shintou, T., Tsuboyama, A., Okano, M., Umemoto, N., Zhang, Z., Kawabata, M., Zhang, B., Kuroyanagi, J., Shimada, Y., Miyazaki, T., Imamura, T., Tomimoto, H., and Tanaka, T. (2013) Identification of a Novel Indoline Derivative for in Vivo Fluorescent Imaging of Blood-Brain Barrier Disruption in Animal Models. ACS Chemical Neuroscience. 4(8):1183-93

Tsuruma, K., Nishimura, Y., Kishi, S., Shimazawa, M., Tanaka, T., and Hara, H. (2012) SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells. Investigative ophthalmology & visual science. 53(10):6729-6737

Watanabe, K., Nishimura, Y., Nomoto, T., Umemoto, N., Zhang, Z., Zhang, B., Kuroyanagi, J., Shimada, Y., Shintou, T., Okano, M., Miyazaki, T., Imamura, T., and Tanaka, T. (2012) In vivo assessment of the permeability of the blood--brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neuroscience. 13(1):101

Hasumura, T., Shimada, Y., Kuroyanagi, J., Nishimura, Y., Meguro, S., Takema, Y., and Tanaka, T. (2012) Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutrition & metabolism. 9(1):73

Shimada, Y., Hirano, M., Nishimura, Y., and Tanaka, T. (2012) A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS One. 7(12):e52549

Tainaka, T., Shimada, Y., Kuroyanagi, J., Zang, L., Oka, T., Nishimura, Y., Nishimura, N., and Tanaka, T. (2011) Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutrition & metabolism. 8(1):88

Zang, L., Morikane, D., Shimada, Y., Tanaka, T., and Nishimura, N. (2011) A novel protocol for the oral administration of test chemicals to adult zebrafish. Zebrafish. 8(4):203-210

Oka, T., Nishimura, Y., Zang, L., Hirano, M., Shimada, Y., Wang, Z., Umemoto, N., Kuroyanagi, J., Nishimura, N., and Tanaka, T. (2010) Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiology. 10:21

Watanabe, K., Nishimura, Y., Oka, T., Nomoto, T., Kon, T., Shintou, T., Hirano, M., Shimada, Y., Umemoto, N., Kuroyanagi, J., Wang, Z., Zhang, Z., Nishimura, N., Miyazaki, T., Imamura, T., and Tanaka, T. (2010) In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neuroscience. 11:116

Wang, Z., Nishimura, Y., Shimada, Y., Umemoto, N., Hirano, M., Zang, L., Oka, T., Sakamoto, C., Kuroyanagi, J., and Tanaka, T. (2009) Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 446(1):18-27

Tanaka, T., Oka, T., Shimada, Y., Umemoto, N., Kuroyanagi, J., Sakamoto, C., Zang, L., Wang, Z., and Nishimura, Y. (2008) Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. Journal of Pharmacological Sciences. 107(1):8-14

NON-ZEBRAFISH PUBLICATIONS