|ZFIN ID: ZDB-PERS-110615-4|
BIOGRAPHY AND RESEARCH INTERESTS
During my masters, I worked with Dr. Craig LaMunyon to characterize a mitochondrial DNA deletion in Caenorhabditis elegans. Specifically, I examined how the deletion affected metabolism, lifespan and sperm performance. In addition, I have also mapped and cloned several genes involved in spermiogenesis, a process by which immature sperm activates to form mature active sperm. In Dr. Carla Koehler's lab, I characterized several mutant fish lines with mitochondrial defects. During the course of this study, I have identified a novel mitochondrial DNA binding protein, Kansl2, which plays a role in the maintenance of mitochondrial DNA. As a postdoctoral research fellow in Dr. Takaomi Sanda's lab, I am currently identifying and characterizing potential therapeutic targets involved in T-cell acute lymphoblastic leukemia.
Leong, W.Z., Tan, S.H., Ngoc, P.C.T., Amanda, S., Yam, A.W.Y., Liau, W.S., Gong, Z., Lawton, L.N., Tenen, D.G., Sanda, T. (2018) ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Genes & Development. 31(23-24):2343-2360
Liau, W.S., Tan, S.H., Ngoc, P.C., Wang, C.Q., Tergaonkar, V., Feng, H., Gong, Z., Osato, M., Look, A.T., Sanda, T. (2017) Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia. 31(8):1798-1807