ZFIN ID: ZDB-PERS-110602-1
Hill, Caroline
Email: caroline.Hill@crick.ac.uk
URL:
Affiliation: Hill Lab
Address: The Francis Crick Institute Lincoln's Inn Fields Laboratory 44 Lincoln's Inn Fields London WC2A 3LY UK
Country: United Kingdom
Phone: +44 20 7269 2941
Fax: +44 20 7269 3093
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
Biography

Caroline Hill carried out her Ph.D studies in the laboratory of Jean Thomas at the University of Cambridge UK, working on chromatin structure. After receiving her Ph.D in 1989 she carried out postdoctoral studies in the same lab before moving in 1991 to Imperial Cancer Research Fund, London, UK to work on the regulation of c-fos gene expression by growth factors with Richard Treisman. In 1995 she set up her own lab at the Ludwig Institute for Cancer Research, London, UK working on signalling by TGF-beta superfamily members in early vertebrate development and cancer. She moved her laboratory to the Cancer Research UK London Research Institute in 1998, where she is now a Principal Scientist.


PUBLICATIONS
Economou, A.D., Guglielmi, L., East, P., Hill, C.S. (2022) Nodal signaling establishes a competency window for stochastic cell fate switching. Developmental Cell. 57:26042622.e52604-2622.e5
Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374
van Boxtel, A.L., Economou, A.D., Heliot, C., Hill, C.S. (2017) Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages. Developmental Cell. 44(2):179-191.e5
van Boxtel, A.L., Chesebro, J.E., Heliot, C., Ramel, M.C., Stone, R.K., Hill, C.S. (2015) A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Developmental Cell. 35:175-185
Ramel, M.C., and Hill, C.S. (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Developmental Biology. 378(2):170-82
Sanvitale, C.E., Kerr, G., Chaikuad, A., Ramel, M.C., Mohedas, A.H., Reichert, S., Wang, Y., Triffitt, J.T., Cuny, G.D., Yu, P.B., Hill, C.S., and Bullock, A.N. (2013) A New Class of Small Molecule Inhibitor of BMP Signaling. PLoS One. 8(4):e62721
Wu, M.Y., Ramel, M.C., Howell, M., and Hill, C.S. (2011) SNW1 Is a Critical Regulator of Spatial BMP Activity, Neural Plate Border Formation, and Neural Crest Specification in Vertebrate Embryos. PLoS Biology. 9(2):e1000593
Batut, J., Howell, M., and Hill, C.S. (2007) Kinesin-mediated transport of smad2 is required for signaling in response to tgf-Beta ligands. Developmental Cell. 12(2):261-274
Dorey, K., and Hill, C.S. (2006) A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos. Developmental Biology. 292(2):303-316
Randall, R.A., Germain, S., Inman, G.J., Bates, P.A., and Hill, C.S. (2002) Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. The EMBO journal. 21(1-2):145-156

NON-ZEBRAFISH PUBLICATIONS
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