ZFIN Person: Zhang, Bo

ZFIN ID: ZDB-PERS-110112-2

ZFIN ID: ZDB-PERS-110112-2

Zhang, Bo

Email:	bzhang@pku.edu.cn
URL:
Affiliation:	PKU Zebrafish Functional Genomics Group
Address:	No 5 YiHeYuan Rd. Haidian District College of Life Sciences Peking University Beijing, 100871 China
Country:	China
Phone:	86-10-62759072
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Sun, L., Ping, L., Fan, X., Fan, Y., Zhang, B., Chen, X. (2024) amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. International Journal of Molecular Sciences. 25(2):

Sun, L., Ping, L., Gao, R., Zhang, B., Chen, X. (2023) lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. Genes. 14(7):

Wu, Z., Shi, Y., Cui, Y., Xing, X., Zhang, L., Liu, D., Zhang, Y., Dong, J., Jin, L., Pang, M., Xiao, R.P., Zhu, Z., Xiong, J.W., Tong, X., Zhang, Y., Wang, S., Tang, F., Zhang, B. (2023) Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Protein & cell. 14:350368350-368

Niu, X., Zhang, F., Ping, L., Wang, Y., Zhang, B., Wang, J., Chen, X. (2023) vwa1 Knockout in Zebrafish Causes Abnormal Craniofacial Chondrogenesis by Regulating FGF Pathway. Genes. 14(4):

Han, B., Zhang, Y., Zhou, Y., Zhang, B., Krueger, C.J., Bi, X., Zhu, Z., Tong, X., Zhang, B. (2022) ErCas12a and T5exo-ErCas12a Mediate Simple and Efficient Genome Editing in Zebrafish. Biology. 11(3):

Li, T., Wang, Y., Li, D., Zhou, J., Zhang, B., He, X. (2021) Potential role for the tumor suppressor CYLD in brain and notochord development. Thoracic cancer. 12(12):1900-1908

Lu, J., Cheng, C., Cheng, Z.C., Wu, Q., Shen, H., Yuan, M.X., Zhang, B., Yang, J.K. (2020) The dual role of RFX6 in directing β cell development and insulin production. Journal of molecular endocrinology. 66(2):129-140

Wang, Y., Ping, L., Luan, X., Chen, Y., Fan, X., Li, L., Liu, Y., Wang, P., Zhang, S., Zhang, B., Chen, X. (2020) A Mutation in VWA1, Encoding von Willebrand Factor A Domain-Containing Protein 1, Is Associated With Hemifacial Microsomia. Frontiers in cell and developmental biology. 8:571004

Han, B., Zhang, Y., Bi, X., Zhou, Y., Krueger, C.J., Hu, X., Zhu, Z., Tong, X., Zhang, B. (2020) Bi-FoRe: an efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators. Protein & cell. 12(1):39-56

Pang, L., Zhang, Z., Shen, Y., Cheng, Z., Gao, X., Zhang, B., Wang, X., Tian, H. (2020) Mutant dlx3b disturbs normal tooth mineralization and bone formation in zebrafish. PeerJ. 8:e8515

Wang, L., Ren, A., Tian, T., Li, N., Cao, X., Zhang, P., Jin, L., Li, Z., Shen, Y., Zhang, B., Finnell, R.H., Lei, Y. (2019) Whole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases. Frontiers in neuroscience. 13:1285

Li, W., Zhang, Y., Han, B., Li, L., Li, M., Lu, X., Chen, C., Lu, M., Zhang, Y., Jia, X., Zhu, Z., Tong, X., Zhang, B. (2019) One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish. eLIFE. 8:

Lu, C.J., Fan, X.Y., Guo, Y.F., Cheng, Z.C., Dong, J., Chen, J.Z., Li, L.Y., Wang, M.W., Wu, Z.K., Wang, F., Tong, X.J., Luo, L.F., Tang, F.C., Zhu, Z.Y., Zhang, B. (2018) Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Journal of molecular cell biology. 11(6):435-447

Wang, K., Zhao, S., Liu, B., Zhang, Q., Li, Y., Liu, J., Shen, Y., Ding, X., Lin, J., Wu, Y., Yan, Z., Chen, J., Li, X., Song, X., Niu, Y., Liu, J., Chen, W., Ming, Y., Du, R., Chen, C., Long, B., Zhang, Y., Tong, X., Zhang, S., Posey, J.E., Zhang, B., Wu, Z., Wythe, J.D., Liu, P., Lupski, J.R., Yang, X., Wu, N. (2018) Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM). Journal of Medical Genetics. 55(10):675-684

Tian, T., Wang, L., Shen, Y., Zhang, B., Finnell, R.H., Ren, A. (2018) Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects. Epigenomics. 10(7):891-901

Yan, Q., Zhai, L., Zhang, B., Dallman, J.E. (2017) Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development. The Journal of comparative neurology. 525(7):1649-1667

Zhao, J., Xu, T., Yin, D., Zhang, B., Bai, J. (2017) The Regulatory Roles of MicroRNA in Effects of 2,2'4,4'-Tetrabromodiphenyl Ether (BDE47) on the Transcriptome of Zebrafish Larvae. PLoS One. 12:e0169599

Zhang, J., Wang, C., Shen, Y., Chen, N., Wang, L., Liang, L., Guo, T., Yin, X., Ma, Z., Zhang, B., Yang, L. (2016) A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa. Human genetics. 135(12):1375-1387

Li, W., Zheng, N.Z., Yuan, Q., Xu, K., Yang, F., Gu, L., Zheng, G.Y., Luo, G.J., Fan, C., Ji, G.J., Zhang, B., Cao, H., Tian, X.L. (2016) NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. Journal of molecular medicine (Berlin, Germany). 94(9):993-1002

Cox, J.A., Zhang, B., Pope, H.M., Voigt, M.M. (2016) Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish. PLoS One. 11:e0148726

Tao, X., Li, C., Zhang, B., He, Y. (2016) Effects of aqueous stable fullerene nanocrystals (nC60) on the food conversion from Daphnia magna to Danio rerio in a simplified freshwater food chain. Chemosphere. 145:157-162

Huang, P., Xiao, A., Tong, X., Lin, S., Zhang, B. (2016) Targeted Mutagenesis in Zebrafish by TALENs. Methods in molecular biology (Clifton, N.J.). 1338:191-206

Zhang, Y., Huang, H., Zhang, B., Lin, S. (2016) TALEN- and CRISPR-enhanced DNA homologous recombination for gene editing in zebrafish. Methods in cell biology. 135:107-20

Xiao, A., Zhang, B. (2016) Generation of Targeted Genomic Deletions Through CRISPR/Cas System in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:65-79

Liu, H.J., Zhang, C.Y., Song, F., Xiao, T., Meng, J., Zhang, Q., Liang, C.L., Li, S., Wang, J., Zhang, B., Liu, Y.R., Sun, T., Zhou, H.G. (2015) A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor γ with Excellent Effect on Insulin Resistance and Type 2 Diabetes. The Journal of pharmacology and experimental therapeutics. 353:573-81

Lee, H.J., Lowdon, R.F., Maricque, B., Zhang, B., Stevens, M., Li, D., Johnson, S.L., Wang, T. (2015) Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos. Nature communications. 6:6315

Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini, A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., Carl, M. (2014) Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons. Current biology : CB. 24(19):2217-27

Huang, P., Xiao, A., Tong, X., Zu, Y., Wang, Z., Zhang, B. (2014) TALEN construction via "Unit Assembly" method and targeted genome modifications in zebrafish. Methods (San Diego, Calif.). 69(1):67-75

Zhang, Y., Ear, J., Yang, Z., Morimoto, K., Zhang, B., Lin, S. (2014) Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death & Disease. 5:e1352

Zheng, C., Zhou, H., Liu, X., Pang, Y., Zhang, B., and Huang, Y. (2014) Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos. Chemical communications (Cambridge, England). 50(8):981-984

Liu, D., Wang, Z., Xiao, A., Zhang, Y., Li, W., Zu, Y., Yao, S., Lin, S., and Zhang, B. (2014) Efficient gene targeting in zebrafish mediated by a zebrafish-codon-optimized cas9 and evaluation of off-targeting effect. Journal of genetics and genomics = Yi chuan xue bao. 41(1):43-46

Tong, X., Zu, Y., Li, Z., Li, W., Ying, L., Yang, J., Wang, X., He, S., Liu, D., Zhu, Z., Chen, J., Lin, S., and Zhang, B. (2014) Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. Nature communications. 5:3153

Xia, Z., Tong, X., Liang, F., Zhang, Y., Kuok, C., Zhang, Y., Liu, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. Developmental Biology. 381(1):83-96

Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic acids research. 41(14):e141

Wang, L., Liu, T., Xu, L., Gao, Y., Wei, Y., Duan, C., Chen, G.Q., Lin, S., Patient, R., Zhang, B., Hong, D., and Liu, F. (2013) Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 122(3):367-75

Jiang, L., Zhang, J., Wang, J.J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu, M., Wang, X., Liu, F., Wu, C.I., He, C., Zhang, B., Ci, W., and Liu, J. (2013) Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 153(4):773-784

Shen, Y., Xiao, A., Huang, P., Wang, W.Y., Zhu, Z.Y., and Zhang, B. (2013) TALE nuclease engineering and targeted genome modification. Yi chuan = Hereditas. 35(4):395-409

Shen, Y., Huang, P., and Zhang, B. (2013) A protocol for TALEN construction and gene targeting in zebrafish. Yi chuan = Hereditas. 35(4):533-544

Liu, X.X., Zhang, Y.T., and Zhang, B. (2013) A surgery protocol to construct zebrafish heart damage and regeneration model. Yi chuan = Hereditas. 35(4):529-532

Zu, Y., Tong, X., Wang, Z., Liu, D., Pan, R., Li, Z., Hu, Y., Luo, Z., Huang, P., Wu, Q., Zhu, Z., Zhang, B., and Lin, S. (2013) TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nature Methods. 10(4):329-31

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Tong, X., Xia, Z., Zu, Y., Telfer, H., Hu, J., Yu, J., Liu, H., Zhang, Q., Sodmergen, D., Lin, S., and Zhang, B. (2013) Ngs (notochord granular surface) encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. The Journal of biological chemistry. 288(4):2711-2720

Huang, P., Xu, L., Liang, W., Tam, C.I., Zhang, Y., Qi, F., Zhu, Z., Lin, S., and Zhang, B. (2013) Genomic deletion induced by Tol2 transposon excision in zebrafish. Nucleic acids research. 41(2):e36

Huang, P., Zhu, Z., Lin, S., and Zhang, B. (2012) Reverse genetic approaches in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):421-433

Mu, Y., Li, X.Q., Zhang, B., and Du, J.L. (2012) Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism. Neuron. 75(4):688-699

Dong, W., Yang, Z., Yang, F., Wang, J., Zhuang, Y., Xu, C., Zhang, B., Tian, X.L., and Liu, D. (2012) Suppression of rap1 impairs cardiac myofibrils and conduction system in zebrafish. PLoS One. 7(11):e50960

Zhang, Y., Morimoto, K., Danilova, N., Zhang, B., and Lin, S. (2012) Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing. PLoS One. 7(1):e30188

Huang, P., Xiao, A., Zhou, M., Zhu, Z., Lin, S., and Zhang, B. (2011) Heritable gene targeting in zebrafish using customized TALENs. Nat. Biotechnol.. 29(8):699-700

Gao, W., Xu, L., Guan, R., Liu, X., Han, Y., Wu, Q., Xiao, Y., Qi, F., Zhu, Z., Lin, S., and Zhang, B. (2011) Wdr18 Is Required for Kupffer's Vesicle Formation and Regulation of Body Asymmetry in Zebrafish. PLoS One. 6(8):e23386

Wen, L., Wei, W., Gu, W., Huang, P., Ren, X., Zhang, Z., Zhu, Z., Lin, S., and Zhang, B. (2008) Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Developmental Biology. 314(1):84-92

NON-ZEBRAFISH PUBLICATIONS