ZFIN ID: ZDB-PERS-101208-2
Flik, Gert
Email: G.Flik@fnwi.ru.nl
URL:
Affiliation: Department of Organismal Animal Physiology
Address: Institute for Water and Wetland Research Faculty of Science Radboud University Nijmegen, Netherlands
Country: Netherlands
Phone: ++31 24 3653242
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
Stress physiology, food intake regulation, calcium regulation, osmoregulation, aquaculture fish welfare.


PUBLICATIONS
Bergen, D.J.M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S.E., Frysz, M., Croucher, P.I., Flik, G., Richardson, R.J., Kemp, J.P., Hammond, C.L., Metz, J.R. (2022) Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology. 20:21
Dona, M., Waaijers, S., Richter, S., Eisenhofer, G., Korving, J., Kamel, S.M., Bakkers, J., Rapizzi, E., Rodenburg, R.J., Zethof, J., Gorissen, M., Flik, G., Deen, P.M.T., Timmers, H.J. (2020) Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics. Endocrine-related cancer. 28(1):65-77
van den Bos, R., Cromwijk, S., Tschigg, K., Althuizen, J., Zethof, J., Whelan, R., Flik, G., Schaaf, M. (2020) Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. Frontiers in immunology. 11:727
van de Pol, I.L.E., Flik, G., Verberk, W.C.E.P. (2020) Triploidy in zebrafish larvae: Effects on gene expression, cell size and cell number, growth, development and swimming performance. PLoS One. 15:e0229468
San, B., Rougeot, J., Voeltzke, K., van Vegchel, G., Aben, M., Andralojc, K.M., Flik, G., Kamminga, L.M. (2019) The ezh2(sa1199) mutant zebrafish display no distinct phenotype. PLoS One. 14:e0210217
van den Bos, R., Zethof, J., Flik, G., Gorissen, M. (2017) Light regimes differentially affect baseline transcript abundance of stress-axis and (neuro)development-related genes in zebrafish (Danio rerio, Hamilton 1822) AB and TL larvae.. Biology Open. 6(11):1692-1697
van den Bos, R., Mes, W., Galligani, P., Heil, A., Zethof, J., Flik, G., Gorissen, M. (2017) Further characterisation of differences between TL and AB zebrafish (Danio rerio): Gene expression, physiology and behaviour at day 5 of the larval stage. PLoS One. 12:e0175420
Manuel, R., Zethof, J., Flik, G., Bos, R.V. (2015) Providing a food reward reduces inhibitory avoidance learning in zebrafish. Behavioural processes. 120:69-72
Dona, M., Bachmann-Gagescu, R., Texier, Y., Toedt, G., Hetterschijt, L., Tonnaer, E.L., Peters, T.A., van Beersum, S.E., Bergboer, J.G., Horn, N., de Vrieze, E., Slijkerman, R.W., van Reeuwijk, J., Flik, G., Keunen, J.E., Ueffing, M., Gibson, T.J., Roepman, R., Boldt, K., Kremer, H., van Wijk, E. (2015) NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish. PLoS Genetics. 11:e1005574
Gorissen, M., Manuel, R., Pelgrim, T.N., Mes, W., de Wolf, M.J., Zethof, J., Flik, G., van den Bos, R. (2015) Differences in inhibitory avoidance, cortisol and brain gene expression in TL and AB zebrafish. Genes, brain, and behavior. 14(5):428-38
de Vrieze, E., Zethof, J., Schulte-Merker, S., Flik, G., Metz, J.R. (2015) Identification of novel osteogenic compounds by an ex-vivo Sp7:luciferase zebrafish scale assay. Bone. 74:106-13
Manuel, R., Gorissen, M., Stokkermans, M., Zethof, J., Ebbesson, L.O., Vis, H.V., Flik, G., Bos, R.V. (2015) The Effects of Environmental Enrichment and Age-Related Differences on Inhibitory Avoidance in Zebrafish (Danio rerio Hamilton). Zebrafish. 12(2):152-65
Manuel, R., Gorissen, M., Zethof, J., Ebbesson, L.O., van de Vis, H., Flik, G., van den Bos, R. (2014) Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase. The Journal of experimental biology. 217(Pt 21):3919-28
Boerrigter, J.G., van de Vis, H.W., van den Bos, R., Abbink, W., Spanings, T., Zethof, J., Martinez, L.L., van Andel, W.F., Lopez-Luna, J., and Flik, G. (2014) Effects of Pro-Tex on zebrafish (Danio rerio) larvae, adult common carp (Cyprinus carpio) and adult yellowtail kingfish (Seriola lalandi). Fish physiology and biochemistry. 40(4):1201-12
Manuel, R., Gorissen, M., Piza Roca, C., Zethof, J., Vis, H.V., Flik, G., Bos, R.V. (2014) Inhibitory Avoidance Learning in Zebrafish (Danio Rerio): Effects of Shock Intensity and Unraveling Differences in Task Performance. Zebrafish. 11(4):341-52
de Vrieze, E., van de Wiel, S.M., Zethof, J., Flik, G., Klaren, P.H., Arjona, F.J. (2014) Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish. Endocrinology. 155(6):2320-30
Arjona, F.J., de Baaij, J.H., Schlingmann, K.P., Lameris, A.L., van Wijk, E., Flik, G., Regele, S., Korenke, G.C., Neophytou, B., Rust, S., Reintjes, N., Konrad, M., Bindels, R.J., Hoenderop, J.G. (2014) CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia. PLoS Genetics. 10:e1004267
de Vrieze, E., Moren, M., Metz, J.R., Flik, G., Lie, K.K. (2014) Arachidonic acid enhances turnover of the dermal skeleton: studies on zebrafish scales. PLoS One. 9:e89347
de Vrieze, E., van Kessel, M.A., Peters, H.M., Spanings, F.A., Flik, G., and Metz, J.R. (2014) Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 25(2):567-78
Arjona, F.J., Chen, Y.X., Flik, G., Bindels, R.J., and Hoenderop, J.G. (2013) Tissue-specific expression and in vivo regulation of zebrafish orthologues of mammalian genes related to symptomatic hypomagnesemia. Pflugers Archiv : European journal of physiology. 465(10):1409-21
Huitema, L.F., Renn, J., Logister, I., Gray, J.K., Waltz, S.E., Flik, G., and Schulte-Merker, S. (2012) Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(10):4092-4101
Wunderink, Y.S., de Vrieze, E., Metz, J.R., Halm, S., Martínez-Rodríguez, G., Flik, G., Klaren, P.H., and Mancera, J.M. (2012) Subfunctionalization of POMC paralogues in Senegalese sole (Solea senegalensis). General and comparative endocrinology. 175(3):407-415
Arjona, F.J., de Vrieze, E., Visser, T.J., Flik, G., and Klaren, P.H. (2011) Identification and Functional Characterization of Zebrafish Solute Carrier Slc16a2 (Mct8) as a Thyroid Hormone Membrane Transporter. Endocrinology. 152(12):5065-73
Vanoevelen, J., Janssens, A., Huitema, L.F., Hammond, C.L., Metz, J.R., Flik, G., Voets, T., and Schulte-Merker, S. (2011) Trpv5/6 is vital for epithelial calcium uptake and bone formation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(9):3197-207
de Vrieze, E., Sharif, F., Metz, J.R., Flik, G., and Richardson, M.K. (2011) Matrix metalloproteinases in osteoclasts of ontogenetic and regenerating zebrafish scales. Bone. 48(4):704-712
Gorissen, M., Bernier, N., Nabuurs, S., Flik, G., and Huising, M. (2009) Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution. The Journal of endocrinology. 201(3):329-339
Sánchez, E., Rubio, V.C., Thompson, D.A., Metz, J., Flik, G., Millhauser, G.L., and Cerda-Reverter, J.M. (2009) Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1293-R1306
Brittijn, S.A., Duivesteijn, S.J., Belmamoune, M., Bertens, L.F., Bitter, W., Debruijn, J.D., Champagne, D.L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C.M., Janssen, R.A., de Jong, I.M., de Kloet, E.R., Kros, A., Meijer, A.H., Metz, J.R., van der Sar, A.M., Schaaf, M.J., Schulte-Merker, S., Spaink, H.P., Tak, P.P., Verbeek, F.J., Vervoordeldonk, M.J., Vonk, F.J., Witte, F., Yuan, H., and Richardson, M.K. (2009) Zebrafish development and regeneration: new tools for biomedical research. The International journal of developmental biology. 53(5-6):835-850
Huising, M.O., Geven, E.J., Kruiswijk, C.P., Nabuurs, S.B., Stolte, E.H., Spanings, F.A., Verburg-van Kemenade, B.M., and Flik, G. (2006) Increased leptin expression in common Carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation. Endocrinology. 147(12):5786-5797
Huising, M.O., Kruiswijk, C.P., and Flik, G. (2006) Phylogeny and evolution of class-I helical cytokines. The Journal of endocrinology. 189(1):1-25
Huising, M.O., van Schijndel, J.E., Kruiswijk, C.P., Nabuurs, S.B., Savelkoul, H.F., Flik, G., and Verburg-van Kemenade, B.M. (2006) The presence of multiple and differentially regulated interleukin-12p40 genes in bony fishes signifies an expansion of the vertebrate heterodimeric cytokine family. Molecular immunology. 43(10):1519-1533
Huising, M.O., Kruiswijk, C.P., van Schijndel, J.E., Savelkoul, H.F., Flik, G., and Verburg-van Kemenade, B.M. (2005) Multiple and highly divergent IL-11 genes in teleost fish. Immunogenetics. 57(6):432-443
Huising, M.O., Metz, J.R., van Schooten, C., Taverne-Thiele, A.J., Hermsen, T., Verburg-van Kemenade, B.M., and Flik, G. (2004) Structural characterisation of a cyprinid (Cyprinus carpio L.) CRH, CRH-BP and CRH-R1, and the role of these proteins in the acute stress response. Journal of molecular endocrinology. 32(3):627-648

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