ZFIN Person: Ozbudak, Ertugrul

ZFIN ID: ZDB-PERS-100806-1

ZFIN ID: ZDB-PERS-100806-1

Ozbudak, Ertugrul

Email:	Ertugrul.Ozbudak@cchmc.org
URL:	http://www.cincinnatichildrens.org/bio/o/ertugrul-ozbudak
Affiliation:	Ozbudak Lab
Address:	Professor of Pediatrics, Laboratory of Systems Developmental Biology Division of Developmental Biology Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Phone: 513 803 2607 Address: 240 Albert Sabin way, Room: S3.621, MLC 7007 Cincinnati, OH 45229-3039
Country:	United States
Phone:	513 803 2607
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Simsek, M.F., Özbudak, E.M. (2021) A 3-D Tail Explant Culture to Study Vertebrate Segmentation in Zebrafish. Journal of visualized experiments : JoVE. (172):

Zinani, O.Q.H., Keseroğlu, K., Ay, A., Özbudak, E.M. (2020) Pairing of segmentation clock genes drives robust pattern formation. Nature. 589(7842):431-436

Keskin, S., Simsek, M.F., Vu, H.T., Yang, C., Devoto, S.H., Ay, A., Özbudak, E.M. (2019) Regulatory Network of the Scoliosis-Associated Genes Establishes Rostrocaudal Patterning of Somites in Zebrafish. iScience. 12:247-259

Simsek, M.F., Özbudak, E.M. (2018) Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish. Cell Reports. 24:66-78.e8

Keskin, S., Devakanmalai, G.S., Kwon, S.B., Vu, H.T., Hong, Q., Lee, Y.Y., Soltani, M., Singh, A., Ay, A., Özbudak, E.M. (2018) Noise in the Vertebrate Segmentation Clock Is Boosted by Time Delays but Tamed by Notch Signaling. Cell Reports. 23:2175-2185.e4

Ay, A., Holland, J., Sperlea, A., Devakanmalai, G.S., Knierer, S., Sangervasi, S., Stevenson, A., Ozbudak, E.M. (2014) Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves. Development (Cambridge, England). 141:4158-67

Ay, A., Knierer, S., Sperlea, A., Holland, J., and Ozbudak, E.M. (2013) Short-lived Her proteins drive robust synchronized oscillations in the zebrafish segmentation clock. Development (Cambridge, England). 140(15):3244-3253

Devakanmalai, G.S., Zumrut, H.E., and Ozbudak, E.M. (2013) Cited3 activates Mef2c to control muscle cell differentiation and survival. Biology Open. 2(5):505-514

Hanisch, A., Holder, M.V., Choorapoikayil, S., Gajewski, M., Ozbudak, E.M., and Lewis, J. (2013) The elongation rate of RNA polymerase II in zebrafish and its significance in the somite segmentation clock. Development (Cambridge, England). 140(2):444-453

Ozbudak, E.M., Tassy, O., and Pourquié, O. (2010) Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Proceedings of the National Academy of Sciences of the United States of America. 107(9):4224-4229

Ozbudak, E.M., and Pourquié, O. (2008) The vertebrate segmentation clock: the tip of the iceberg. Current opinion in genetics & development. 18(4):317-323

Gomez, C., Ozbudak, E.M., Wunderlich, J., Baumann, D., Lewis, J., and Pourquié, O. (2008) Control of segment number in vertebrate embryos. Nature. 454(7202):335-339

Ozbudak, E.M., and Lewis, J. (2008) Notch Signalling Synchronizes the Zebrafish Segmentation Clock but Is Not Needed To Create Somite Boundaries. PLoS Genetics. 4(2):e15

Lewis, J., and Ozbudak, E.M. (2007) Deciphering the somite segmentation clock: beyond mutants and morphants. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(6):1410-1415

Giudicelli, F., Ozbudak, E.M., Wright, G.J., and Lewis, J. (2007) Setting the Tempo in Development: An Investigation of the Zebrafish Somite Clock Mechanism. PLoS Biology. 5(6):e150

NON-ZEBRAFISH PUBLICATIONS
Özbudak EM, Thattai M, Kurtser I, Grossman AD, van Oudenaarden A. Regulation of noise in the expression of a single gene. Nature Genetics, 31(1):69-73, (2002). Faculty of 1000 Biology Evaluation: F1000 Factor 9.0 (Exceptional) (Jun 2002).

Özbudak EM, Thattai M, Lim HN, Shraiman BI, Van Oudenaarden A. Multistability in the lactose utilization network of Escherichia coli. Nature, 427(6976):737-740, (2004). Faculty of 1000 Biology Evaluation: F1000 Factor 8.1 (Exceptional) (Jun 2004).

Özbudak EM, Becskei A, van Oudenaarden A. A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization. Dev. Cell. 9(4):565-571, (2005). Faculty of 1000 Biology Evaluation: F1000 Factor 3 (Recommended) (Nov 2005).

Mettetal JT, Muzzey D, Pedraza JM, Özbudak EM, van Oudenaarden A. Predicting stochastic gene expression dynamics in single cells. Proc Natl Acad Sci USA, 103(19):7304-9, (2006).