ZFIN Person: Ott, Elisabeth B.

ZFIN ID: ZDB-PERS-100805-8

ZFIN ID: ZDB-PERS-100805-8

Ott, Elisabeth B.

Email:	elisabeth.ott@uniklinik-freiburg.de
URL:
Affiliation:	Elisabeth Ott Lab
Address:	Universitätsklinikum Freiburg IMITATE Breisacher Str. 113 79106 Freiburg Germany
Country:
Phone:	+4976127063101
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

In our lab we are interested in the identification and characterization of new candidates for polycystic kidney disease and related ciliopathies. To aim this goal we use patient derived fibroblasts and urine derived renal epithelial cells for ciliogenesis and ciliary trafficking studies. We further use the zebrafish to model the disease in knockdown and knockout experiments. We investigate defective cell signaling processes and study the ciliary protein network, with specific interest in the ciliary transition zone at the base of the cilium.

During my master studies in Molecular and Cellular Biology in the group of Prof Bagowski at the University in Leiden, the Netherlands, I gained first interest in the zebrafish model organism. My PhD studies I performed in the group of Prof. Meyer at the Institute of Molecular Biology at the University in Innsbruck, Austria.

PUBLICATIONS

Ott, E., Hoff, S., Indorf, L., Ditengou, F.A., Müller, J., Renschler, G., Lienkamp, S.S., Kramer-Zucker, A., Bergmann, C., Epting, D. (2023) A novel role for the chloride intracellular channel protein Clic5 in ciliary function. Scientific Reports. 13:1764717647

Devane, J., Ott, E., Olinger, E.G., Epting, D., Decker, E., Friedrich, A., Bachmann, N., Renschler, G., Eisenberger, T., Briem-Richter, A., Grabhorn, E.F., Powell, L., Wilson, I.J., Rice, S.J., Miles, C.G., Wood, K., Genomics England Research Consortium, Trivedi, P., Hirschfield, G., Pietrobattista, A., Wohler, E., Mezina, A., Sobreira, N., Agolini, E., Maggiore, G., Dahmer-Heath, M., Yilmaz, A., Boerries, M., Metzger, P., Schell, C., Grünewald, I., Konrad, M., König, J., Schlevogt, B., Sayer, J.A., Bergmann, C. (2022) Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations. American journal of human genetics. 109(5):928-943

Epting, D., Decker, E., Ott, E., Eisenberger, T., Bader, I., Bachmann, N., Bergmann, C. (2022) The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies. Human molecular genetics. 31(14):2295-2306

Epting, D., Senaratne, L.D.S., Ott, E., Holmgren, A., Sumathipala, D., Larsen, S.M., Wallmeier, J., Bracht, D., Frikstad, K.M., Crowley, S., Sikiric, A., Barøy, T., Käsmann-Kellner, B., Decker, E., Decker, C., Bachmann, N., Patzke, S., Phelps, I.G., Katsanis, N., Giles, R., Schmidts, M., Zucknick, M., Lienkamp, S.S., Omran, H., Davis, E.E., Doherty, D., Strømme, P., Frengen, E., Bergmann, C., Misceo, D. (2020) Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome. Human Mutation. 41(12):2179-2194

Lu, H., Galeano, M.C.R., Ott, E., Kaeslin, G., Kausalya, P.J., Kramer, C., Ortiz-Brüchle, N., Hilger, N., Metzis, V., Hiersche, M., Tay, S.Y., Tunningley, R., Vij, S., Courtney, A.D., Whittle, B., Wühl, E., Vester, U., Hartleben, B., Neuber, S., Frank, V., Little, M.H., Epting, D., Papathanasiou, P., Perkins, A.C., Wright, G.D., Hunziker, W., Gee, H.Y., Otto, E.A., Zerres, K., Hildebrandt, F., Roy, S., Wicking, C., Bergmann, C. (2017) Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nature Genetics. 49:1025–1034

Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D. (2016) Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm. Developmental Biology. 411(1):101-14

Ott, I., Kircher, B., Bagowski, C.P., Vlecken, D.H., Ott, E.B., Will, J., Bensdorf, K., Sheldrick, W.S., Gust, R. (2009) Modulation of the Biological Properties of Aspirin by Formation of a Bioorganometallic Derivative. Angewandte Chemie (International ed. in English). 48:1160-3

Vlecken, D.H., Testerink, J., Ott, E.B., Sakalis, P.A., Jaspers, R.T., and Bagowski, C.P. (2009) A critical role for myoglobin in zebrafish development. The International journal of developmental biology. 53(4):517-524

Ott, E.B., van den Akker, N.M., Sakalis, P.A., Gittenberger-de Groot, A.C., Te Velthuis, A.J., and Bagowski, C.P. (2008) The lim domain only protein 7 is important in zebrafish heart development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3940-3952

Bertola, L.D., Ott, E.B., Griepsma, S., Vonk F.J., Bagowski, C.P. (2008) Developmental expression of the alpha-skeletal actin gene. BMC Evolutionary Biology. 8:166

Ott, E.B., Sakalis, P.A., Marques, I.J., and Bagowski, C.P. (2007) Characterization of the enigma family in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(11):3144-3154

Ott, E.B., Te Velthuis, A.J., and Bagowski, C.P. (2007) Comparative analysis of splice form-specific expression of LIM Kinases during zebrafish development. Gene expression patterns : GEP. 7(5):620-629

Te Velthuis, A.J., Ott, E.B., Marques, I.J., and Bagowski, C.P. (2007) Gene expression patterns of the ALP family during zebrafish development. Gene expression patterns : GEP. 7(3):297-305

NON-ZEBRAFISH PUBLICATIONS