ZFIN Person: Nie, Pin

ZFIN ID: ZDB-PERS-090406-10

ZFIN ID: ZDB-PERS-090406-10

Nie, Pin

Email:	pinnie@ihb.ac.cn
URL:
Affiliation:
Address:	Institute of Hydrobiology Chinese Academy of Sciences 7 South Donghu Road Wuhan, Hubei Province, 430072 China
Country:
Phone:	+86-27-68780736
Fax:	+86-27-68780123
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Deng, Y.H., Li, B., Chen, S.N., Ren, L., Zhang, B.D., Liu, L.H., Liu, S., Nie, P. (2023) Molecular characterization of nineteen cytokine receptor family B (CRFB) members, CRFB1, CRFB2, CRFB4-17, with three CRFB9 and two CRFB14 in a cyprinid fish, the blunt snout bream Megalobrama amblycephala. Developmental and comparative immunology. 145:104725

Chen, S.N., Li, B., Gan, Z., Wang, K.L., Li, L., Pang, A.N., Peng, X.Y., Ji, J.X., Deng, Y.H., Li, N., Liu, L.H., Sun, Y.L., Wang, S., Huang, B., Nie, P. (2023) Transcriptional Regulation and Signaling of Type IV IFN with Identification of the ISG Repertoire in an Amphibian Model, Xenopus laevis. Journal of immunology (Baltimore, Md. : 1950). 210(11):1771-1789

Huang, L., Zhang, L., Huo, H.J., Hou, J., Niu, M.M., Nie, P., Chen, S.N. (2023) FTR33, a member of fish-specific TRIM (finTRIM) subfamily, regulates negatively type I IFN antiviral immunity in zebrafish. Developmental and comparative immunology. 142:104671104671

Chen, S.N., Gan, Z., Hou, J., Yang, Y.C., Huang, L., Huang, B., Wang, S., Nie, P. (2022) Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications. 13:999

Chen, S.N., Gan, Z., Nie, P. (2021) Retroposition of the Long Transcript from Multiexon IFN-β Homologs in Ancestry Vertebrate Gave Rise to the Proximal Transcription Elements of Intronless IFN-β Promoter in Humans. Journal of immunology (Baltimore, Md. : 1950). 207(10):2512-2520

Li, B., Chen, S.N., Ren, L., Wang, S., Liu, L., Liu, Y., Liu, S., Nie, P. (2020) Identification of type I IFNs and their receptors in a cyprinid fish, the topmouth culter Culter alburnus. Fish & shellfish immunology. 102:326-335

Wu, X.M., Zhang, J., Li, P.W., Hu, Y.W., Cao, L., Ouyang, S., Bi, Y.H., Nie, P., Chang, M.X. (2020) NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of immunology (Baltimore, Md. : 1950). 204(8):2216-2231

He, T.T., Zhou, Y., Liu, Y.L., Li, D.Y., Nie, P., Li, A.H., Xie, H.X. (2020) Edwardsiella piscicida type III protein EseJ suppresses apoptosis through down regulating type 1 fimbriae, which stimulate the cleavage of caspase-8. Cellular Microbiology. 22(7):e13193

Gan, Z., Cheng, J., Hou, J., Xia, H., Chen, W., Xia, L., Nie, P., Lu, Y. (2020) Molecular and functional characterization of tilapia DDX41 in IFN regulation. Fish & shellfish immunology. 99:386-391

Zhang, C., Zhang, Q., Wang, J., Tian, J., Song, Y., Xie, H., Chang, M., Nie, P., Gao, Q., Zou, J. (2019) Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish & shellfish immunology. 94:685-696

Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143

Zhai, G., Shu, T., Xia, Y., Lu, Y., Shang, G., Jin, X., He, J., Nie, P., Yin, Z. (2018) Characterization of sexual trait development in cyp17a1-deficient zebrafish. Endocrinology. 159(10):3549-3562

Wu, X.M., Chen, W.Q., Hu, Y.W., Cao, L., Nie, P., Chang, M.X. (2018) RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in immunology. 9:726

Cao, L., Wu, X.M., Hu, Y.W., Xue, N.N., Nie, P., Chang, M.X. (2018) The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. Developmental and comparative immunology. 84:153-163

Hu, Y.W., Zhang, J., Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2018) TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Frontiers in immunology. 9:84

Li, N., Zhu, Y., LaFrentz, B.R., Evenhuis, J.P., Hunnicutt, D.W., Conrad, R.A., Barbier, P., Gullstrand, C.W., Roets, J.E., Powers, J.L., Kulkarni, S.S., Erbes, D.H., García, J.C., Nie, P., McBride, M.J. (2017) The type IX secretion system is required for virulence of the fish pathogen Flavobacterium columnare. Applied and environmental microbiology. 83(23)

Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979

Ruan, B.Y., Chen, S.N., Hou, J., Huang, B., Laghari, Z.A., Li, L., Nie, P. (2017) Two type II IFN members, IFN-γ and IFN-γ related (rel), regulate differentially IRF1 and IRF11 in zebrafish. Fish & shellfish immunology. 65:103-110

Chen, S.N., Zou, P.F., Nie, P. (2017) Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current knowledge and future perspectives. Immunology. 151:16-25

Wu, X.M., Hu, Y.W., Xue, N.N., Ren, S.S., Chen, S.N., Nie, P., Chang, M.X. (2017) Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Developmental and comparative immunology. 68:58-68

Zou, P.F., Nie, P. (2017) Zebrafish as a Model for the Study of Host-Virus Interactions. Methods in molecular biology (Clifton, N.J.). 1656:57-78

Zou, P.F., Chang, M.X., Li, Y., Xue, N.N., Li, J.H., Chen, S.N., Nie, P. (2016) NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS. Fish & shellfish immunology. 55:173-85

Zhang, L., Chen, W.Q., Hu, Y.W., Wu, X.M., Nie, P., Chang, M.X. (2016) TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish & shellfish immunology. 54:135-43

Lu, L.F., Li, S., Lu, X.B., LaPatra, S.E., Zhang, N., Zhang, X.J., Chen, D.D., Nie, P., Zhang, Y.A. (2016) Spring Viremia of Carp Virus N Protein Suppresses Fish IFNφ1 Production by Targeting the Mitochondrial Antiviral Signaling Protein. Journal of immunology (Baltimore, Md. : 1950). 196(9):3744-53

Chen, W.Q., Hu, Y.W., Zou, P.F., Ren, S.S., Nie, P., Chang, M.X. (2015) MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Developmental and comparative immunology. 49:19-30

Zou, P.F., Chang, M.X., Li, Y., Zhang, S.H., Fu, J.P., Chen, S.N., Nie, P. (2015) Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish & shellfish immunology. 43(1):13-24

Hu, Y.W., Yu, Z.L., Xue, N.N., Nie, P., Chang, M.X. (2014) Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Developmental and comparative immunology. 46(2):323-32

Li, S., Lu, L.F., Feng, H., Wu, N., Chen, D.D., Zhang, Y.B., Gui, J.F., Nie, P., Zhang, Y.A. (2014) IFN Regulatory Factor 10 Is a Negative Regulator of the IFN Responses in Fish. Journal of immunology (Baltimore, Md. : 1950). 193(3):1100-9

Zou, P.F., Chang, M.X., Xue, N.N., Liu, X.Q., Li, J.H., Fu, J.P., Chen, S.N., and Nie, P. (2014) Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 141(2):192-202

Li, J.H., Yu, Z.L., Xue, N.N., Zou, P.F., Hu, J.Y., Nie, P., and Chang, M.X. (2014) Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Developmental and comparative immunology. 42(20):244-255

Huang, B., Huang, W.S., and Nie, P. (2013) Characterization of four Mx isoforms in the European eel, Anguilla anguilla. Fish & shellfish immunology. 35(3):1048-54

Xiao, F.S., Wang, Y.P., Yan, W., Chang, M.X., Yao, W.J., Xu, Q.Q., Wang, X.X., Gao, Q., and Nie, P. (2010) Ig heavy chain genes and their locus in grass carp Ctenopharyngodon idella. Fish & shellfish immunology. 29(4):594-599

Huang, B., Qi, Z.T., Xu, Z., and Nie, P. (2010) Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution. BMC immunology. 11:22

Xu, Q.Q., Chang, M.X., Xiao, F.S., Huang, B., and Nie, P. (2010) The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 134(3-4):269-278

Chen, W.Q., Xu, Q.Q., Chang, M.X., Zou, J., Secombes, C.J., Peng, K.M., and Nie, P. (2010) Molecular characterization and expression analysis of the IFN-gamma related gene (IFN-gammarel) in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 134(3-4):199-207

Chang, M.X., Chen, W.Q., and Nie, P. (2010) Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Developmental and comparative immunology. 34(1):1-13

Chang, M.X., Wang, Y.P., and Nie, P. (2009) Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish & shellfish immunology. 26(2):264-274

Liu, Y., Chang, M.X., Wu, S.G., and Nie, P. (2009) Characterization of C-C chemokine receptor subfamily in teleost fish. Molecular immunology. 46(3):498-504

Chang, M.X., and Nie, P. (2008) RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Veterinary Immunology and Immunopathology. 124(3-4):295-301

Xu, Z.Y., Sun, B.J., Chang, M.X., and Nie, P. (2008) Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 121(1-2):44-57

Chang, M.X., Nie, P., and Wei, L.L. (2007) Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Molecular immunology. 44(11):3005-3023

Chang, M.X., Nie, P., Xie, H.X., Wang, G.L., and Gao, Y. (2006) Characterization and expression analysis of TNF-related apoptosis inducing ligand (TRAIL) in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 110(1-2):51-63

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