ZFIN Person: Presta, Marco

ZFIN ID: ZDB-PERS-081121-6

ZFIN ID: ZDB-PERS-081121-6

Presta, Marco

Email:	presta@med.unibs.it
URL:	http://www.med.unibs.it/~airc/
Affiliation:	Presta Lab
Address:	General Pathology and Immunology Department of Biomedical Sciences and Biotechnology School of Medicine, University of Brescia viale Europa 11, 25123 Brescia, Italy
Country:	Italy
Phone:	++39-0303717311
Fax:	++39-0303701157
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Marco PRESTA, born on June 21, 1954, Italy; Italian; 1977: PhD in Biological Sciences, University of Milan, Italy; 1984-86: Research Fellow, School of Medicine, N.Y.U. Medical Center, N.Y., U.S.A; 1984-87: Research Assistant Professor, Univ. Brescia, Italy; 1987-2000: Associate Professor; 2000-today: Full Professor in General Pathology, Univ. Brescia, Italy.

Scientific Societies: American Society for Cell Biology, New York Academy of Sciences, American Association Cancer Research.

Fields of Research: 1975-77: Quantification of ischemic damage in miocardium and skeletric muscle; 1977-79: Hepatic tumor promoters and liver growth; 1980: Human embryonic hemoglobins and globin chains in leukemic cells lines; 1980-84: Genotoxic and oncogenic activity of beta-adrenoreceptor blocking agents; 1984-present: Tumor angiogenesis, purification and characterization of human angiogenic factors (FGFs), identification of their functional domains and interaction with sulfated glycosaminoglycans, FGF/receptor interaction and signal transduction, FGF overexpression in tumor and endothelial cells.

Editorial Board: Endothelium, Angiogenesis.

Journal Peer Reviewer: Arteriosclerosis, Thrombosis, and Vascular Biology, Cell Growth & Differentiation, EMBO Journal, European Journal of Cancer, European Journal of Clinical Investigation, Growth Factors, International Journal of Cancer, International Journal of Clinical and Laboratory Research, Regulatory Peptides, Journal of Cell Biology, Journal of Cellular Physiology, Journal of Endocrinology, Journal of Leukocyte Biology.

Granting Agency Reviewer: The Wellcome Trust, London;The Flemish Foundation for Scientific Research (FWO), Brussels;International Human Frontier Science Program, Strasbourg;The Israel Science Foundation, Jerusalem;NATO Scientific Affairs Division (Collaborative Research Grants), Brussels;Istituto Superiore di Sanità (AIDS Projects)and CNR (Target Project Biotechnology), Italy

PUBLICATIONS

Basnet, R.M., Zizioli, D., Muscò, A., Finazzi, D., Sigala, S., Rossini, E., Tobia, C., Guerra, J., Presta, M., Memo, M. (2021) Caffeine Inhibits Direct and Indirect Angiogenesis in Zebrafish Embryos. International Journal of Molecular Sciences. 22(9):

Belleri, M., Paganini, G., Coltrini, D., Ronca, R., Zizioli, D., Corsini, M., Barbieri, A., Grillo, E., Calza, S., Bresciani, R., Maiorano, E., Mastropasqua, M.G., Annese, T., Giacomini, A., Ribatti, D., Casas, J., Levade, T., Fabrias, G., Presta, M. (2020) BETA-GALACTOSYLCERAMIDASE PROMOTES MELANOMA GROWTH VIA MODULATION OF CERAMIDE METABOLISM. Cancer research. 80(22):5011-5023

Guerra, J., Chiodelli, P., Tobia, C., Gerri, C., Presta, M. (2020) Long-Pentraxin 3 Affects Primary Cilium in Zebrafish Embryo and Cancer Cells via the FGF System. Cancers. 12(7):

Ronca, R., Ghedini, G.C., Maccarinelli, F., Sacco, A., Locatelli, S.L., Foglio, E., Taranto, S., Grillo, E., Matarazzo, S., Castelli, R., Paganini, G., Desantis, V., Cattane, N., Cattaneo, A., Mor, M., Carlo-Stella, C., Belotti, A., Roccaro, A.M., Presta, M., Giacomini, A. (2020) FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation-Induced Mitochondrial Oxidative Stress. Cancer research. 80:2340-2354

Rezzola, S., Ronca, R., Loda, A., Nawaz, M.I., Tobia, C., Paganini, G., Maccarinelli, F., Giacomini, A., Semeraro, F., Mor, M., Presta, M. (2019) The Autocrine FGF/FGFR System in both Skin and Uveal Melanoma: FGF Trapping as a Possible Therapeutic Approach. Cancers. 11(9):

Tobia, C., Chiodelli, P., Barbieri, A., Buraschi, S., Ferrari, E., Mitola, S., Borsani, G., Guerra, J., Presta, M. (2019) Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. Frontiers in immunology. 10:1092

Zizioli, D., Mione, M., Varinelli, M., Malagola, M., Bernardi, S., Alghisi, E., Borsani, G., Finazzi, D., Monti, E., Presta, M., Russo, D. (2018) Zebrafish disease models in hematology: Highlights on biological and translational impact. Biochimica et biophysica acta. Molecular basis of disease. 1865(3):620-633

Nawaz, I.M., Chiodelli, P., Rezzola, S., Paganini, G., Corsini, M., Lodola, A., Di Ianni, A., Mor, M., Presta, M. (2018) N-tert-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) inhibits the angiogenic activity of heparin-binding growth factors. Angiogenesis. 21:47-59

Belleri, M., Presta, M. (2016) Endothelial cell dysfunction in globoid cell leukodystrophy. Journal of neuroscience research. 94(11):1359-67

Consigli, V., Guarienti, M., Bilo, F., Benassi, L., Depero, L.E., Bontempi, E., Presta, M. (2016) Evaluation of the Biotoxicity of Tree Wood Ashes in Zebrafish Embryos. Zebrafish. 13(5):449-55

Guarienti, M., Cardozo, S.M., Borgese, L., Lira, G.R., Depero, L.E., Bontempi, E., Presta, M. (2016) COSMOS-rice technology abrogates the biotoxic effects of municipal solid waste incinerator residues. Environmental pollution (Barking, Essex : 1987). 214:713-721

Rezzola, S., Paganini, G., Semeraro, F., Presta, M., Tobia, C. (2016) Zebrafish (Danio rerio) embryo as a platform for the identification of novel angiogenesis inhibitors of retinal vascular diseases. Biochimica et biophysica acta. Molecular basis of disease. 1862(7):1291-6

Liekens, S., Noppen, S., Gijsbers, S., Sienaert, R., Ronca, R., Tobia, C., Presta, M. (2015) The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors. Oncotarget. 6(7):4633-48

Tobia, C., Gariano, G., Guerra, J., Presta, M. (2015) Zebrafish embryo intersegmental vessels: a tool for investigating sprouting angiogenesis. Methods in molecular biology (Clifton, N.J.). 1214:173-84

Guarienti, M., Gianoncelli, A., Bontempi, E., Moscoso Cardozo, S., Borgese, L., Zizioli, D., Mitola, S., Depero, L.E., Presta, M. (2014) Biosafe inertization of municipal solid waste incinerator residues by COSMOS technology. Journal of hazardous materials. 279C:311-321

Rezzola, S., Belleri, M., Gariano, G., Ribatti, D., Costagliola, C., Semeraro, F., and Presta, M. (2014) In vitro and ex vivo retina angiogenesis assays. Angiogenesis. 17(3):429-42

Zizioli, D., Guarienti, M., Tobia, C., Gariano, G., Borsani, G., Bresciani, R., Ronca, R., Giacopuzzi, E., Preti, A., Gaudenzi, G., Belleri, M., Di Salle, E., Fabrias, G., Casas, J., Ribatti, D., Monti, E., and Presta, M. (2014) Molecular cloning and knockdown of galactocerebrosidase in zebrafish: New insights into the pathogenesis of Krabbe's disease. Biochimica et biophysica acta. Molecular basis of disease. 1842(4):665-675

Tobia, C., Gariano, G., Sena, G.D., and Presta, M. (2013) Zebrafish embryo as a tool to study tumor/endothelial cell cross-talk. Biochimica et biophysica acta. Molecular basis of disease. 1832(9):1371-7

Tobia, C., Chiodelli, P., Nicoli, S., Dell'era, P., Buraschi, S., Mitola, S., Foglia, E., van Loenen, P.B., Alewijnse, A.E., and Presta, M. (2012) Sphingosine-1-Phosphate Receptor-1 Controls Venous Endothelial Barrier Integrity in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 32(9):e104-116

Yeh, J.C., Cindrova-Davies, T., Belleri, M., Morbidelli, L., Miller, N., Cho, C.W., Chan, K., Wang, Y.T., Luo, G.A., Ziche, M., Presta, M., Charnock-Jones, D.S., and Fan, T.P. (2011) The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo. Angiogenesis. 14(2):187-97

Tobia, C., De Sena, G., and Presta, M. (2011) Zebrafish embryo, a tool to study tumor angiogenesis. The International journal of developmental biology. 55(4-5):505-509

Leali, D., Bianchi, R., Bugatti, A., Nicoli, S., Mitola, S., Ragona, L., Tomaselli, S., Gallo, G., Catello, S., Rivieccio, V., Zetta, L., and Presta, M. (2010) Fibroblast Growth Factor 2-antagonist Activity of a Long-Pentraxin 3-derived Antiangiogenic Pentapeptide. Journal of Cellular and Molecular Medicine. 14(8):2109-2121

Urbinati, C., Nicoli, S., Giacca, M., David, G., Fiorentini, S., Caruso, A., Alfano, M., Cassetta, L., Presta, M., and Rusnati, M. (2009) HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium. Blood. 114(15):3335-3342

Nicoli, S., De Sena, G., and Presta, M. (2009) Fibroblast Growth Factor 2-induced angiogenesis in zebrafish: the zebrafish yolk membrane (ZFYM) angiogenesis assay. Journal of Cellular and Molecular Medicine. 13(8b):2061-2068

Nicoli, S., Tobia, C., Gualandi, L., De Sena, G., and Presta, M. (2008) Calcitonin receptor-like receptor guides arterial differentiation in Zebrafish. Blood. 111(10):4965-4972

Nicoli, S., Ribatti, D., Cotelli, F., and Presta, M. (2007) Mammalian tumor xenografts induce neovascularization in zebrafish embryos. Cancer research. 67(7):2927-2931

Nicoli, S., and Presta, M. (2007) The zebrafish/tumor xenograft angiogenesis assay. Nature Protocols. 2(11):2918-2923

Nicoli, S., Gilardelli, C.N., Pozzoli, O., Presta, M., and Cotelli, F. (2005) Regulated expression pattern of gremlin during zebrafish development. Gene expression patterns : GEP. 5(4):539-544

NON-ZEBRAFISH PUBLICATIONS
1. Andres G, Leali D, Mitola S, et al. A Pro-inflammatory Signature Mediates FGF2-induced Angiogenesis. J Cell Mol Med 2008.

2. Stabile H, Mitola S, Moroni E, et al. Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood 2007;109:1834-40.

3. Rusnati M, Presta M. Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies. Curr Pharm Des 2007;13:2025-44.

4. Presta M, Camozzi M, Salvatori G, Rusnati M. Role of the soluble pattern recognition receptor PTX3 in vascular biology. J Cell Mol Med 2007;11:723-38.

5. Leali D, Moroni E, Bussolino F, Presta M. Osteopontin overexpression inhibits in vitro re-endothelialization via integrin engagement. J Biol Chem 2007;282:19676-84.

6. Rusnati M, Presta M. Extracellular angiogenic growth factor interactions: an angiogenesis interactome survey. Endothelium 2006;13:93-111.

7. Ribatti D, Nico B, Vacca A, Presta M. The gelatin sponge-chorioallantoic membrane assay. Nat Protoc 2006;1:85-91.

8. Mitola S, Belleri M, Urbinati C, et al. Cutting edge: extracellular high mobility group box-1 protein is a proangiogenic cytokine. J Immunol 2006;176:12-5.

9. Camozzi M, Rusnati M, Bugatti A, et al. Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem 2006;281:22605-13.

10. Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, Rusnati M. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 2005;16:159-78.

11. Camozzi M, Zacchigna S, Rusnati M, et al. Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo. Arterioscler Thromb Vasc Biol 2005;25:1837-42.

12. Riboldi E, Musso T, Moroni E, et al. Cutting edge: proangiogenic properties of alternatively activated dendritic cells. J Immunol 2005;175:2788-92.

13. Rusnati M, Camozzi M, Moroni E, et al. Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis. Blood 2004;104:92-9.

14. Belleri M, Ribatti D, Nicoli S, et al. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. Mol Pharmacol 2005;67:1451-9.

15. Casu B, Guerrini M, Guglieri S, et al. Undersulfated and glycol-split heparins endowed with antiangiogenic activity. J Med Chem 2004;47:838-48.