ZFIN Person: Bagnat, Michel

ZFIN ID: ZDB-PERS-070927-3

ZFIN ID: ZDB-PERS-070927-3

Bagnat, Michel

Email:	m.bagnat@cellbio.duke.edu
URL:	http://www.cellbio.duke.edu/Faculty/Research/Bagnat.html
Affiliation:	Bagnat Lab
Address:	333B Nanaline Duke Bldg., Box 3709, Duke University Medical Center, Durham, NC 27710 USA
Country:	United States
Phone:	919-681-9268
Fax:	919-684-5481
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Peskin, B., Norman, J., Bagwell, J., Lin, A., Adhyapok, P., Di Talia, S., Bagnat, M. (2023) Dynamic BMP signaling mediates notochord segmentation in zebrafish. Current biology : CB. 33(12):2574-2581.e3

Zhou, K.C., Harfouche, M., Cooke, C.L., Park, J., Konda, P.C., Kreiss, L., Kim, K., Jönsson, J., Doman, T., Reamey, P., Saliu, V., Cook, C.B., Zheng, M., Bechtel, J.P., Bègue, A., McCarroll, M., Bagwell, J., Horstmeyer, G., Bagnat, M., Horstmeyer, R. (2023) Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second. Nature photonics. 17:442450442-450

Levic, D.S., Bagnat, M. (2022) Polarized transport of membrane and secreted proteins during lumen morphogenesis. Seminars in cell & developmental biology. 133:65-73

Levic, D.S., Yamaguchi, N., Wang, S., Knaut, H., Bagnat, M. (2021) Knock-in tagging in zebrafish facilitated by insertion into non-coding regions. Development (Cambridge, England). 148(19):

Hachimi, M., Grabowski, C., Campanario, S., Herranz, G., Baonza, G., Serrador, J.M., Gomez-Lopez, S., Barea, M.D., Bosch-Fortea, M., Gilmour, D., Bagnat, M., Rodriguez-Fraticelli, A.E., Martin-Belmonte, F. (2020) Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis. Current biology : CB. 31(4):696-706.e9

Bagnat, M., Gray, R.S. (2020) Development of a straight vertebrate body axis. Development (Cambridge, England). 147(21):

Peskin, B., Henke, K., Cumplido, N., Treaster, S., Harris, M.P., Bagnat, M., Arratia, G. (2020) Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. Current biology : CB. 30(14):2805-2814.e3

Levic, D.S., Ryan, S., Marjoram, L., Honeycutt, J., Bagwell, J., Bagnat, M. (2020) Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. The Journal of cell biology. 219(4):

Bagwell, J., Norman, J., Ellis, K.L., Peskin, B., Hwang, J., Ge, X., Nguyen, S., McMenamin, S.K., Stainier, D.Y., Bagnat, M. (2020) Notochord vacuoles absorb compressive bone growth during zebrafish spine formation. eLIFE. 9:

Ye, L., Mueller, O., Bagwell, J., Bagnat, M., Liddle, R.A., Rawls, J.F. (2019) High fat diet induces microbiota-dependent silencing of enteroendocrine cells. eLIFE. 8:

Park, J., Levic, D.S., Sumigray, K.D., Bagwell, J., Eroglu, O., Block, C.L., Eroglu, C., Barry, R., Lickwar, C.R., Rawls, J.F., Watts, S.A., Lechler, T., Bagnat, M. (2019) Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. Developmental Cell. 51(1):7-20.e6

Norman, J., Sorrell, E.L., Hu, Y., Siripurapu, V., Garcia, J., Bagwell, J., Charbonneau, P., Lubkin, S.R., Bagnat, M. (2018) Tissue self-organization underlies morphogenesis of the notochord. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1759):

Wopat, S., Bagwell, J., Sumigray, K.D., Dickson, A.L., Huitema, L.F.A., Poss, K.D., Schulte-Merker, S., Bagnat, M. (2018) Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Reports. 22:2026-2038

Goudarzi, M., Tarbashevich, K., Mildner, K., Begemann, I., Garcia, J., Paksa, A., Reichman-Fried, M., Mahabaleshwar, H., Blaser, H., Hartwig, J., Zeuschner, D., Galic, M., Bagnat, M., Betz, T., Raz, E. (2017) Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Developmental Cell. 43(5):577-587.e5

van der Vaart, M., Svoboda, O., Weijts, B.G., Espín-Palazón, R., Sapp, V., Pietri, T., Bagnat, M., Muotri, A.R., Traver, D. (2017) Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.. Disease models & mechanisms. 10(12):1439-1451

Garcia, J., Bagwell, J., Njaine, B., Norman, J., Levic, D.S., Wopat, S., Miller, S.E., Liu, X., Locasale, J.W., Stainier, D.Y.R., Bagnat, M. (2017) Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord. Current biology : CB. 27(13):1982-1989.e3

Smith, C.J., Wheeler, M.A., Marjoram, L., Bagnat, M., Deppmann, C.D., Kucenas, S. (2017) TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. PLoS Genetics. 13:e1006712

Cao, J., Navis, A., Cox, B.D., Dickson, A.L., Gemberling, M., Karra, R., Bagnat, M., Poss, K.D. (2016) Single epicardial cell transcriptome sequencing identifies Caveolin-1 as an essential factor in zebrafish heart regeneration. Development (Cambridge, England). 143(2):232-43

Navis, A., Bagnat, M. (2015) Loss of cftr function leads to pancreatic destruction in larval zebrafish. Developmental Biology. 399(2):237-48

Marjoram, L., Alvers, A., Deerhake, M.E., Bagwell, J., Mankiewicz, J., Cocchiaro, J.L., Beerman, R.W., Willer, J., Sumigray, K.D., Katsanis, N., Tobin, D.M., Rawls, J.F., Goll, M.G., Bagnat, M. (2015) Epigenetic control of intestinal barrier function and inflammation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(9):2770-5

Rodríguez-Fraticelli, A.E., Bagwell, J., Bosch-Fortea, M., Boncompain, G., Reglero-Real, N., García-León, M.J., Andrés, G., Toribio, M.L., Alonso, M.A., Millán, J., Perez, F., Bagnat, M., Martín-Belmonte, F. (2015) Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. Nature cell biology. 17(3):241-50

Alvers, A.L., Ryan, S., Scherz, P.J., Huisken, J., and Bagnat, M. (2014) Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. Development (Cambridge, England). 141(5):1110-1119

Gray, R.S., Wilm, T.P., Smith, J., Bagnat, M., Dale, R.M., Topczewski, J., Johnson, S.L., and Solnica-Krezel, L. (2014) Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Developmental Biology. 386(1):72-85

Ryan, S., Willer, J., Marjoram, L., Bagwell, J., Mankiewicz, J., Leshchiner, I., Goessling, W., Bagnat, M., and Katsanis, N. (2013) Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development (Cambridge, England). 140(21):4445-4451

Ellis, K., Hoffman, B.D., and Bagnat, M. (2013) The vacuole within: How cellular organization dictates notochord function. Bioarchitecture. 3(3):64-68

Navis, A., Marjoram, L., and Bagnat, M. (2013) Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. Development (Cambridge, England). 140(8):1703-1712

Ellis, K., Bagwell, J., and Bagnat, M. (2013) Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. The Journal of cell biology. 200(5):667-679

Cheung, I.D., Bagnat, M., Ma, T.P., Datta, A., Evason, K., Moore, J.C., Lawson, N.D., Mostov, K.E., Moens, C.B., and Stainier, D.Y. (2012) Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Developmental Biology. 361(1):68-78

Kanther, M., Sun, X., Mühlbauer, M., Mackey, L.C., Flynn, E.J., Bagnat, M., Jobin, C., and Rawls, J.F. (2011) Microbial colonization induces dynamic temporal and spatial patterns of NF-kappaB activation in the zebrafish digestive tract. Gastroenterology. 141(1):197-207

Bagnat, M., Navis, A., Herbstreith, S., Brand-Arzamendi, K., Curado, S., Gabriel, S., Mostov, K., Huisken, J., and Stainier, D.Y. (2010) Cse1l Is a Negative Regulator of CFTR-Dependent Fluid Secretion. Current biology : CB. 20(20):1840-1845

Bagnat, M., Cheung, I.D., Mostov, K.E., and Stainier, D.Y. (2007) Genetic control of single lumen formation in the zebrafish gut. Nature cell biology. 9(8):954-960

NON-ZEBRAFISH PUBLICATIONS
Cse1l Is a Negative Regulator of CFTR-Dependent Fluid Secretion.
Bagnat M, Navis A, Herbstreith S, Brand-Arzamendi K, Curado S, Gabriel S, Mostov K, Huisken J, Stainier DY.
Curr Biol. 2010 Oct 6. [Epub ahead of print]

Proszynski, T., Simons, K., and Bagnat, M. (2004) O-Glycosylation as a Sorting Determinant for Cell Surface Delivery in Yeast. Mol. Biol. Cell 15(4):1533-1543

Bagnat, M., and Simons, K. Cell surface polarization during yeast mating. (2002) Proc. Natl. Acad. Sci. USA. 99(22): 14183-14188

Bagnat, M., Chang, A., and Simons, K. (2001) Plasma Membrane Proton ATPase Pma1p Requires Raft Association for Surface Delivery in Yeast. Mol. Biol. Cell 2001 12(12):4129-4138

Bagnat, M., Keränen, S., Shevchenko, A., Shevchenko, A., and Simons, K. (2000) Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast Proc. Natl. Acad. Sci. USA. 97(7): 3254-3259