ZFIN Person: Tobin, David

ZFIN ID: ZDB-PERS-070206-3

ZFIN ID: ZDB-PERS-070206-3

Tobin, David

Email:	david.tobin@duke.edu
URL:	http://mgm.duke.edu/faculty/tobin/index.html
Affiliation:	Tobin Lab
Address:	Department of Molecular Genetics and Microbiology Duke University Medical Center DUMC 3020, Jones Building Room 219 Durham, NC 27710
Country:	United States
Phone:	919-684-9152
Fax:	919-684-2790
ORCID ID:	0000-0003-3465-5518

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Brewer, W.J., Xet-Mull, A.M., Yu, A., Sweeney, M.I., Walton, E.M., Tobin, D.M. (2022) Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. Cell Reports. 41:111817111817

Saelens, J.W., Sweeney, M.I., Viswanathan, G., Xet-Mull, A.M., Jurcic Smith, K.L., Sisk, D.M., Hu, D.D., Cronin, R.M., Hughes, E.J., Brewer, W.J., Coers, J., Champion, M.M., Champion, P.A., Lowe, C.B., Smith, C.M., Lee, S., Stout, J.E., Tobin, D.M. (2022) An ancestral mycobacterial effector promotes dissemination of infection. Cell. 185(24):4507-4525.e18

Pagán, A.J., Lee, L.J., Edwards-Hicks, J., Moens, C.B., Tobin, D.M., Busch-Nentwich, E.M., Pearce, E.L., Ramakrishnan, L. (2022) mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. Cell. 185(20):3720-3738.e13

Kam, J.Y., Cheng, T., Garland, D.C., Britton, W.J., Tobin, D.M., Oehlers, S.H. (2022) Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish. Pathogens and disease. 80(1):

Wang, Y., Hsu, A.Y., Walton, E.M., Park, S.J., Syahirah, R., Wang, T., Zhou, W., Ding, C., Lemke, A.P., Zhang, G., Tobin, D.M., Deng, Q. (2021) A robust and flexible CRISPR/Cas9 based system for neutrophil-specific gene inactivation in zebrafish. Journal of Cell Science. 134(8):

Cronan, M.R., Hughes, E.J., Brewer, W.J., Viswanathan, G., Hunt, E.G., Singh, B., Mehra, S., Oehlers, S.H., Gregory, S.G., Kaushal, D., Tobin, D.M. (2021) A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. Cell. 184(7):1757-1774.e14

McClean, C.M., Tobin, D.M. (2020) Early cell-autonomous accumulation of neutral lipids during infection promotes mycobacterial growth. PLoS One. 15:e0232251

Espenschied, S.T., Cronan, M.R., Matty, M.A., Mueller, O., Redinbo, M.R., Tobin, D.M., Rawls, J.F. (2019) Epithelial delamination is protective during pharmaceutical-induced enteropathy. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16961-16970

Cronan, M.R., Tobin, D.M. (2019) Endogenous Tagging at the cdh1 Locus for Live Visualization of E-Cadherin Dynamics. Zebrafish. 16:324-325

Hortle, E., Johnson, K.E., Johansen, M.D., Nguyen, T., Shavit, J.A., Britton, W.J., Tobin, D.M., Oehlers, S.H. (2019) Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish. The Journal of infectious diseases. 220(3):524-534

Patton, E.E., Tobin, D.M. (2019) Spotlight on zebrafish: the next wave of translational research. Disease models & mechanisms. 12(3)

Murdoch, C.C., Espenschied, S.T., Matty, M.A., Mueller, O., Tobin, D.M., Rawls, J.F. (2019) Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. PLoS pathogens. 15:e1007381

Matty, M.A., Knudsen, D.R., Walton, E.M., Beerman, R.W., Cronan, M.R., Pyle, C.J., Hernandez, R.E., Tobin, D.M. (2019) Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection. eLIFE. 8:

Cronan, M.R., Matty, M.A., Rosenberg, A.F., Blanc, L., Pyle, C.J., Espenschied, S.T., Rawls, J.F., Dartois, V., Tobin, D.M. (2018) An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas. Nature Methods. 15:1098-1107

Walton, E.M., Cronan, M.R., Cambier, C.J., Rossi, A., Marass, M., Foglia, M.D., Brewer, W.J., Poss, K.D., Stainier, D.Y.R., Bertozzi, C.R., Tobin, D.M. (2018) Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell Host & Microbe. 24:514-525.e6

Alvarez, M.I., Glover, L.C., Luo, P., Wang, L., Theusch, E., Oehlers, S.H., Walton, E.M., Tram, T.T.B., Kuang, Y.L., Rotter, J.I., McClean, C.M., Chinh, N.T., Medina, M.W., Tobin, D.M., Dunstan, S.J., Ko, D.C. (2017) Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol.. Proceedings of the National Academy of Sciences of the United States of America. 114(37):E7746-E7755

Oehlers, S.H., Cronan, M.R., Beerman, R.W., Johnson, M.G., Huang, J., Kontos, C.D., Stout, J.E., Tobin, D.M. (2017) Infection-induced vascular permeability aids mycobacterial growth. The Journal of infectious diseases. 215(5):813-817

Sullivan, C., Matty, M.A., Jurczyszak, D., Gabor, K.A., Millard, P.J., Tobin, D.M., Kim, C.H. (2017) Infectious disease models in zebrafish. Methods in cell biology. 138:101-136

Cronan, M.R., Beerman, R.W., Rosenberg, A.F., Saelens, J.W., Johnson, M.G., Oehlers, S.H., Sisk, D.M., Jurcic Smith, K.L., Medvitz, N.A., Miller, S.E., Trinh, L.A., Fraser, S.E., Madden, J.F., Turner, J., Stout, J.E., Lee, S., Tobin, D.M. (2016) Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity. 45:861-876

Matty, M.A., Beerman, R.W., Tobin, D.M. (2016) Drug-Inducible, Cell-Specific Manipulation of Intracellular Calcium in Zebrafish through Mammalian TRPV1 Expression. Zebrafish. 13(4):374-5

Berg, R.D., Levitte, S., O'Sullivan, M.P., O'Leary, S.M., Cambier, C.J., Cameron, J., Takaki, K.K., Moens, C.B., Tobin, D.M., Keane, J., Ramakrishnan, L. (2016) Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. Cell. 165:139-152

Matty, M.A., Oehlers, S.H., Tobin, D.M. (2016) Live Imaging of Host-Pathogen Interactions in Zebrafish Larvae. Methods in molecular biology (Clifton, N.J.). 1451:207-23

Beerman, R.W., Matty, M.A., Au, G.G., Looger, L.L., Choudhury, K.R., Keller, P.J., Tobin, D.M. (2015) Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux. Cell Reports. 13(10):2107-17

Cronan, M.R., Rosenberg, A.F., Oehlers, S.H., Saelens, J.W., Sisk, D.M., Smith, K.L., Lee, S., Tobin, D.M. (2015) CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. Disease models & mechanisms. 8(12):1643-50

Walton, E.M., Cronan, M.R., Beerman, R.W., Tobin, D.M. (2015) The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish. PLoS One. 10:e0138949

Tenor, J.L., Oehlers, S.H., Yang, J.L., Tobin, D.M., Perfect, J.R. (2015) Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion. mBio. 6(5):e01425-15

Wang, L., Oehlers, S.H., Espenschied, S.T., Rawls, J.F., Tobin, D.M., Ko, D.C. (2015) CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation. Genome biology. 16:190

Marjoram, L., Alvers, A., Deerhake, M.E., Bagwell, J., Mankiewicz, J., Cocchiaro, J.L., Beerman, R.W., Willer, J., Sumigray, K.D., Katsanis, N., Tobin, D.M., Rawls, J.F., Goll, M.G., Bagnat, M. (2015) Epigenetic control of intestinal barrier function and inflammation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(9):2770-5

Oehlers, S.H., Cronan, M.R., Scott, N.R., Thomas, M.I., Okuda, K.S., Walton, E.M., Beerman, R.W., Crosier, P.S., Tobin, D.M. (2015) Interception of host angiogenic signalling limits mycobacterial growth. Nature. 517(7536):612-5

Cronan, M.R., Tobin, D.M. (2014) Fit for consumption: zebrafish as a model for tuberculosis. Disease models & mechanisms. 7:777-784

Whipps, C.M., Moss, L.G., Sisk, D.M., Murray, K.N., Tobin, D.M., and Moss, J.B. (2014) Detection of autofluorescent Mycobacterium chelonae in living zebrafish. Zebrafish. 11(1):76-82

Cambier, C.J., Takaki, K.K., Larson, R.P., Hernandez, R.E., Tobin, D.M., Urdahl, K.B., Cosma, C.L., and Ramakrishnan, L. (2014) Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature. 505(7482):218-222

Tobin, D.M., and Ramakrishnan, L. (2013) TB: the Yin and Yang of lipid mediators. Current opinion in pharmacology. 13(4):641-5

Tobin, D.M., Roca, F.J., Oh, S.F., McFarland, R., Vickery, T.W., Ray, J.P., Ko, D.C., Zou, Y., Bang, N.D., Chau, T.T., Vary, J.C., Hawn, T.R., Dunstan, S.J., Farrar, J.J., Thwaites, G.E., King, M.C., Serhan, C.N., and Ramakrishnan, L. (2012) Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 148(3):434-446

Tobin, D.M., May, R.C., and Wheeler, R.T. (2012) Zebrafish: a see-through host and a fluorescent toolbox to probe host-pathogen interaction. PLoS pathogens. 8(1):e1002349

Tobin, D.M., Vary, J.C. Jr, Ray, J.P., Walsh, G.S., Dunstan, S.J., Bang, N.D., Hagge, D.A., Khadge, S., King, M.C., Hawn, T.R., Moens, C.B., and Ramakrishnan, L. (2010) The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans. Cell. 140(5):717-730

Tobin, D.M., and Ramakrishnan, L. (2008) Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. Cellular Microbiology. 10(5):1027-1039

NON-ZEBRAFISH PUBLICATIONS
Tobin DM, Bargmann CI. Invertebrate nociception: behaviors, neurons and molecules. J Neurobiol. 2004 Oct;61(1):161-74.

Liedtke W*, Tobin DM*, Bargmann CI, Friedman JM. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2:14531-6.

de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 2002 Oct 31;419(6910):899-903.

Tobin DM, Madsen DM, Kahn-Kirby AH, Peckol E, Moulder G, Barstead R, Maricq AV, Bargmann CI. Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Neuron. 2002 Jul 18;35(2):307-18.

Zallen JA, Peckol EL, Tobin DM, Bargmann CI. Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Mol Biol Cell. 2000 Sep;11(9):3177-90.

Chou JH, Troemel ER, Sengupta P, Colbert HA, Tong L, Tobin DM, Roayaie K, Crump JG, Dwyer ND, Bargmann CI. Olfactory recognition and discrimination in Caenorhabditis elegans.
Cold Spring Harb Symp Quant Biol. 1996;61:157-64.