ZFIN Person: Ohata, Shinya

ZFIN ID: ZDB-PERS-060711-6

ZFIN ID: ZDB-PERS-060711-6

Ohata, Shinya

Email:	shiohata@musashino-u.ac.jp
URL:
Affiliation:	Ohata Lab
Address:	Faculty of Pharmacy, Musashino University 1-1-20 Shinmachi, Nishi-Tokyo, Tokyo 202-8585
Country:	Japan
Phone:	+81-42-468-8649
Fax:	+81-42-468-8664
ORCID ID:	0000-0003-4333-4433

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Fowler, G., French, D., Rose, A., Squires, P., Anecito da Silva, C., Ohata, S., Okamoto, H., French, C.R. (2021) Protein fucosylation is required for Notch dependent vascular integrity in zebrafish. Developmental Biology. 480:62-68

Ohata, S., Uga, H., Okamoto, H., Katada, T. (2018) Small GTPase R-Ras participates in neural tube formation in zebrafish embryonic spinal cord. Biochemical and Biophysical Research Communications. 501(3):786-790

Ohata, S., Aoki, R., Kinoshita, S., Yamaguchi, M., Tsuruoka-Kinoshita, S., Tanaka, H., Wada, H., Watabe, S., Tsuboi, T., Masai, I., and Okamoto, H. (2011) Dual Roles of Notch in Regulation of Apically Restricted Mitosis and Apicobasal Polarity of Neuroepithelial Cells. Neuron. 69(2):215-230

Seo, J., Asaoka, Y., Nagai, Y., Hirayama, J., Yamasaki, T., Namae, M., Ohata, S., Shimizu, N., Negishi, T., Kitagawa, D., Kondoh, H., Furutani-Seiki, M., Penninger, J.M., Katada, T., and Nishina, H. (2010) Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Journal of cellular biochemistry. 110(4):1022-1037

Ohata, S., Kinoshita, S., Aoki, R., Tanaka, H., Wada, H., Tsuruoka-Kinoshita, S., Tsuboi, T., Watabe, S., and Okamoto, H. (2009) Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain. Development (Cambridge, England). 136(10):1653-1663

NON-ZEBRAFISH PUBLICATIONS
Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T, Kontani K.
Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos.
J. Cell Sci. 130(20):3568-3577. 2017

Takagishi M, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M.
Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.
Cell Rep. 20(4):960-972. 2017

Ohata S, Álvarez-Buylla A.
Planar organization of multiciliated ependymal (E1) cells in the brain ventricular epithelium.
Trends Neurosci. 2016 39(8): 543-551. 2016

Hirota H, Sawada M, Huang SH, Ogino T, Ohata S, Kubo A, Sawamoto K.
Roles of Wnt signaling in the neurogenic niche of the adult mouse ventricular-subventricular zone.
Neurochem. Res. 41(1-2): 222-30. 2016

Ohata S, Herranz-Pérez V, Nakatani J, Boletta A, García-Verdugo JM, Álvarez-Buylla A.
Mechanosensory genes Pkd1 and Pkd2 contribute to the planar polarization of brain ventricular epithelium.
J. Neurosci. 35(31): 11153-68. 2015

Ohata S, Nakatani J, Herranz-Pérez V, Belinson H, Inubushi T, Snider WD, García-Verdugo JM, Wynshaw-Boris A, Álvarez-Buylla A.
Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.
Neuron 83(3): 558-571. 2014

Ohata S, Nawa M, Kasama T, Yamasaki T, Sawanobori K, Hata S, Nakamura T, Asaoka Y, Watanabe T, Okamoto H, Hara T, Terai S, Sakaida I, Katada T, Nishina H.
Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.
Biochem. Biophys. Res. Commun. 379(4): 817-23. 2009

Yamamoto N, Terai S, Ohata S, Watanabe T, Omori K, Shinoda K, Miyamoto K, Katada T, Sakaida I, Nishina H, Okita K.
A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver.
Biochem. Biophys. Res. Commun. 313(4): 1110-8. 2004

Nishitai G, Shimizu N, Negishi T, Kishimoto H, Nakagawa K, Kitagawa D, Watanabe T, Momose H, Ohata S, Tanemura S, Asaka S, Kubota J, Saito R, Yoshida H, Mak TW, Wada T, Penninger JM, Azuma N, Nishina H, Katada T.
Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.
J. Biol. Chem. 279(3): 1621-6. 2004

Terai S, Sakaida I, Yamamoto N, Omori K, Watanabe T, Ohata S, Katada T, Miyamoto K, Shinoda K, Nishina H, Okita K.
An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes.
J. Biochem. 134(4): 551-8. 2003

Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S, Tanemura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, Sasaki T, Wada T, Penninger JM, Nishina H, Katada T.
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells.
J. Biol. Chem. 278(19): 16595-601. 2003

Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak TW, Penninger JM, Nishina H, Katada T.
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Dev. Biol. 250(2): 332-47. 2002

Kitagawa D, Tanemura S, Ohata S, Shimizu N, Seo J, Nishitai G, Watanabe T, Nakagawa K, Kishimoto H, Wada T, Tezuka T, Yamamoto T, Nishina H, Katada T.
Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function.
J. Biol. Chem. 277(1): 366-71. 2002