ZFIN Person: Hsiao, Chung-Der

ZFIN ID: ZDB-PERS-060601-3

ZFIN ID: ZDB-PERS-060601-3

Hsiao, Chung-Der

Email:	cdhsiao@yahoo.com.tw
URL:	http://cdhsiao.weebly.com
Affiliation:	Epidermal Stem Cell Lab
Address:	Epidermal Stem Cell Lab Department of Bioscience Technology Chung Yuan Christian Univ. 200, Chung Pei Rd. Chung-Li, 32023 Taiwan
Country:
Phone:	886-3-2653545
Fax:	886-3-2653599
ORCID ID:	0000-0002-6398-8672

BIOGRAPHY AND RESEARCH INTERESTS

Chung-Der Hsiao is Professor of Chung Yuan Christian University for Department of Bioscience Technology. He completed the undergraduate and graduate education in National Taiwan University. For postdoctoral training, he joined Dr. Pung-Pung Hwang's group at ICOB, Academia Sinica, and worked on fish physiology and bioinformatics. By 2007, Chung-Der was recruited by Chung Yuan Christian University and established his own laboratory, where he used the cutting-edge methods to generate many zebrafish disease models like apoptosis, obesity, skin cancer and aging. From 2012, Chung-Der was invited by GeneTex International Corp, Zgenebio Biotech and Taikong Corp as research consultant to initiate several cooperation projects on developing zebrafish antibodies, TALEN/CRISPR genome editing tools, transgenic fish as well as Next Generation Sequencing technologies. From 2019, Chung-Der was promoted as professor of Chung Yuan Christian University. Chung-Der is author of over 100 high impact journal articles. He is frequently invited to talk at international and local conferences across a diverse range of fields, and has also spoken to school, student and public audiences. His research has strong application potentials and several patents have been issued regarding to use zebrafish as a human disease models like aging, obesity and cancer.

PUBLICATIONS

Feng, W.W., Chen, H.C., Audira, G., Suryanto, M.E., Saputra, F., Kurnia, K.A., Vasquez, R.D., Casuga, F.P., Lai, Y.H., Hsiao, C.D., Hung, C.H. (2024) Evaluation of Tacrolimus' Adverse Effects on Zebrafish in Larval and Adult Stages by Using Multiple Physiological and Behavioral Endpoints. Biology. 13(2):

Chang, W.C., Chen, M.J., Hsiao, C.D., Hu, R.Z., Huang, Y.S., Chen, Y.F., Yang, T.H., Tsai, G.Y., Chou, C.W., Chen, R.S., Chuang, Y.J., Liu, Y.W. (2023) The anti-platelet drug cilostazol enhances heart rate and interrenal steroidogenesis and exerts a scant effect on innate immune responses in zebrafish. PLoS One. 18:e0292858e0292858

Audira, G., Huang, J.C., Chen, K.H., Kurnia, K.A., Vasquez, R.D., Roldan, M.J.M., Lai, Y.H., Hsiao, C.D., Yen, C.Y. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115641115641

Saputra, F., Lai, Y.H., Roldan, M.J.M., Alos, H.C., Aventurado, C.A., Vasquez, R.D., Hsiao, C.D. (2023) The Effect of the Pyrethroid Pesticide Fenpropathrin on the Cardiac Performance of Zebrafish and the Potential Mechanism of Toxicity. Biology. 12(9):

Balitaan, J.N.I., Luo, W.J., Su, Y.W., Yu, C.Y., Wu, T.Y., Chang, C.A., Jia, H.W., Lin, S.R., Hsiao, C.D., Yeh, J.M. (2023) Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties. ACS applied bio materials. 6(2):552-565

Siregar, P., Audira, G., Castillo, A.L., Roldan, M.J.M., Suryanto, M.E., Liu, R.X., Lin, Y.T., Lai, Y.H., Hsiao, C.D. (2022) Comparison of the psychoactive activity of four primary Areca nut alkaloids in zebrafish by behavioral approach and molecular docking. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 155:113809

Farhan, A., Saputra, F., Suryanto, M.E., Humayun, F., Pajimna, R.M.B., Vasquez, R.D., Roldan, M.J.M., Audira, G., Lai, H.T., Lai, Y.H., Hsiao, C.D. (2022) OpenBloodFlow: A User-Friendly OpenCV-Based Software Package for Blood Flow Velocity and Blood Cell Count Measurement for Fish Embryos. Biology. 11(10):

Lin, H.C., Saputra, F., Audira, G., Lai, Y.H., Roldan, M.J.M., Alos, H.C., Aventurado, C.A., Vasquez, R.D., Tsai, G.J., Lim, K.H., Hsiao, C.D. (2022) Investigating Potential Cardiovascular Toxicity of Two Anti-Leukemia Drugs of Asciminib and Ponatinib in Zebrafish Embryos. International Journal of Molecular Sciences. 23(19):

Suryanto, M.E., Saputra, F., Kurnia, K.A., Vasquez, R.D., Roldan, M.J.M., Chen, K.H., Huang, J.C., Hsiao, C.D. (2022) Using DeepLabCut as a Real-Time and Markerless Tool for Cardiac Physiology Assessment in Zebrafish. Biology. 11(8)

Young, A.Y.W., Audira, G., Saputra, F., Alos, H.C., Aventurado, C.A., Lai, Y.H., Vasquez, R.D., Hsiao, C.D., Hung, C.H. (2022) Toxicity Assessment of an Anti-Cancer Drug of p-Toluene Sulfonamide in Zebrafish Larvae Based on Cardiovascular and Locomotion Activities. Biomolecules. 12(8)

Suryanto, M.E., Yang, C.C., Audira, G., Vasquez, R.D., Roldan, M.J.M., Ger, T.R., Hsiao, C.D. (2022) Evaluation of Locomotion Complexity in Zebrafish after Exposure to Twenty Antibiotics by Fractal Dimension and Entropy Analysis. Antibiotics (Basel, Switzerland). 11(8)

Audira, G., Suryanto, M.E., Chen, K.H., Vasquez, R.D., Roldan, M.J.M., Yang, C.C., Hsiao, C.D., Huang, J.C. (2022) Acute and Chronic Effects of Fin Amputation on Behavior Performance of Adult Zebrafish in 3D Locomotion Test Assessed with Fractal Dimension and Entropy Analyses and Their Relationship to Fin Regeneration. Biology. 11(7)

Lin, Y.T., Liu, R.X., Audira, G., Suryanto, M.E., Roldan, M.J.M., Lee, J.S., Ger, T.R., Hsiao, C.D. (2022) Lanthanides Toxicity in Zebrafish Embryos Are Correlated to Their Atomic Number. Toxics. 10(6)

Chan, K.Y., Yan, C.S., Roan, H.Y., Hsu, S.C., Tseng, T.L., Hsiao, C.D., Hsu, C.P., Chen, C.H. (2022) Skin cells undergo asynthetic fission to expand body surfaces in zebrafish. Nature. 605(7908):119-125

Farhan, A., Kurnia, K.A., Saputra, F., Chen, K.H., Huang, J.C., Roldan, M.J.M., Lai, Y.H., Hsiao, C.D. (2021) An OpenCV-Based Approach for Automated Cardiac Rhythm Measurement in Zebrafish from Video Datasets. Biomolecules. 11(10):

Duan, X.Y., Ma, R.J., Hsiao, C.D., Jiang, Z.Z., Zhang, L.Y., Zhang, Y., Liu, K.C. (2021) Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish. Chinese Journal of Natural Medicines. 19:750-757

Abbas, K., Saputra, F., Suryanto, M.E., Lai, Y.H., Huang, J.C., Yu, W.H., Chen, K.H., Lin, Y.T., Hsiao, C.D. (2021) Evaluation of Effects of Ractopamine on Cardiovascular, Respiratory, and Locomotory Physiology in Animal Model Zebrafish Larvae. Cells. 10(9):

Feng, Z., Lin, C., Tu, L., Su, M., Song, C., Liu, S., Suryanto, M.E., Hsiao, C.D., Li, L. (2021) FDA-Approved Drug Screening for Compounds That Facilitate Hematopoietic Stem and Progenitor Cells (HSPCs) Expansion in Zebrafish. Cells. 10(8):

Du, Z.C., Xia, Z.S., Zhang, M.Z., Wei, Y.T., Malhotra, N., Saputra, F., Audira, G., Roldan, M.J.M., Hsiao, C.D., Hao, E.W., Hou, X.T., Deng, J.G. (2021) Sub-lethal Camphor Exposure Triggers Oxidative Stress, Cardiotoxicity, and Cardiac Physiology Alterations in Zebrafish Embryos. Cardiovascular Toxicology. 21(11):901-913

Kurnia, K.A., Santoso, F., Sampurna, B.P., Audira, G., Huang, J.C., Chen, K.H., Hsiao, C.D. (2021) TCMacro: A Simple and Robust ImageJ-Based Method for Automated Measurement of Tail Coiling Activity in Zebrafish. Biomolecules. 11(8):

Li, P., Zhang, M., Xie, D., Zhang, X., Zhang, S., Gao, F., Wang, Y., Hsiao, C.D., Li, X., Liu, K. (2021) Characterization and bioactivities of phospholipids from squid viscera and gonads using ultra-performance liquid chromatography-Q-exactive orbitrap/mass spectrometry-based lipidomics and zebrafish models. Food & function. 12(17):7986-7996

Audira, G., Siregar, P., Chen, K.H., Roldan, M.J.M., Huang, J.C., Lai, H.T., Hsiao, C.D. (2021) Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics. International Journal of Molecular Sciences. 22(11):

Siregar, P., Audira, G., Feng, L.Y., Lee, J.H., Santoso, F., Yu, W.H., Lai, Y.H., Li, J.H., Lin, Y.T., Chen, J.R., Hsiao, C.D. (2021) Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation. toxins. 13(4):

Suryanto, M.E., Audira, G., Uapipatanakul, B., Hussain, A., Saputra, F., Siregar, P., Chen, K.H., Hsiao, C.D. (2021) Antidepressant Screening Demonstrated Non-Monotonic Responses to Amitriptyline, Amoxapine and Sertraline in Locomotor Activity Assay in Larval Zebrafish. Cells. 10(4):

Audira, G., Lee, J.S., Siregar, P., Malhotra, N., Rolden, M.J.M., Huang, J.C., Chen, K.H., Hsu, H.S., Hsu, Y., Ger, T.R., Hsiao, C.D. (2021) Comparison of the chronic toxicities of graphene and graphene oxide toward adult zebrafish by using biochemical and phenomic approaches. Environmental pollution (Barking, Essex : 1987). 278:116907

Gao, M., Xing, C., Jiang, X., Xu, L., Li, P., Hsiao, C.D. (2021) Highly selective fluorescence detection of Cu²⁺ based on Schiff base functionalized Periodic Mesoiporous Organosilicas. Luminescence : the journal of biological and chemical luminescence. 36(4):951-957

Zhang, F., Han, L., Wang, J., Shu, M., Liu, K., Zhang, Y., Hsiao, C., Tian, Q., He, Q. (2021) Clozapine Induced Developmental and Cardiac Toxicity on Zebrafish Embryos by Elevating Oxidative Stress. Cardiovascular Toxicology. 21(5):399-409

Wang, J., Liu, K., Mo, C., Oleksandr, M.H., Zhang, Y., Chen, J.R., Hsiao, C.D., Zhu, Q., He, Q. (2020) Nano-titanium nitride causes developmental toxicity in zebrafish through oxidative stress. Drug and chemical toxicology. 45(4):1660-1669

Lai, Y.H., Audira, G., Liang, S.T., Siregar, P., Suryanto, M.E., Lin, H.C., Villalobos, O., Villaflores, O.B., Hao, E., Lim, K.H., Hsiao, C.D. (2020) Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish. Genes. 11(11):

Robea, M.A., Jijie, R., Nicoara, M., Plavan, G., Ciobica, A.S., Solcan, C., Audira, G., Hsiao, C.D., Strungaru, S.A. (2020) Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile. Antioxidants (Basel, Switzerland). 9(10):

Audira, G., Ngoc Anh, N.T., Ngoc Hieu, B.T., Malhotra, N., Siregar, P., Villalobos, O., Villaflores, O.B., Ger, T.R., Huang, J.C., Chen, K.H., Hsiao, C.D. (2020) Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments. Biomolecules. 10(9):

Santoso, F., Farhan, A., Castillo, A.L., Malhotra, N., Saputra, F., Kurnia, K.A., Chen, K.H., Huang, J.C., Chen, J.R., Hsiao, C.D. (2020) An Overview of Methods for Cardiac Rhythm Detection in Zebrafish. Biomedicines. 8(9):

Hussain, A., Audira, G., Malhotra, N., Uapipatanakul, B., Chen, J.R., Lai, Y.H., Huang, J.C., Chen, K.H., Lai, H.T., Hsiao, C.D. (2020) Multiple Screening of Pesticides Toxicity in Zebrafish and Daphnia Based on Locomotor Activity Alterations. Biomolecules. 10(9):

Hsiao, C.D., Wu, H.H., Malhotra, N., Liu, Y.C., Wu, Y.H., Lin, Y.N., Saputra, F., Santoso, F., Chen, K.H. (2020) Expression and Purification of Recombinant GHK Tripeptides Are Able to Protect against Acute Cardiotoxicity from Exposure to Waterborne-Copper in Zebrafish. Biomolecules. 10(9):

Malhotra, N., Villaflores, O.B., Audira, G., Siregar, P., Lee, J.S., Ger, T.R., Hsiao, C.D. (2020) Toxicity Studies on Graphene-Based Nanomaterials in Aquatic Organisms: Current Understanding. Molecules. 25(16)

Siregar, P., Juniardi, S., Audira, G., Lai, Y.H., Huang, J.C., Chen, K.H., Chen, J.R., Hsiao, C.D. (2020) Method Standardization for Conducting Innate Color Preference Studies in Different Zebrafish Strains. Biomedicines. 8(8):

Audira, G., Siregar, P., Strungaru, S.A., Huang, J.C., Hsiao, C.D. (2020) Which Zebrafish Strains Are More Suitable to Perform Behavioral Studies? A Comprehensive Comparison by Phenomic Approach. Biology. 9(8)

Audira, G., Siregar, P., Chen, J.R., Lai, Y.H., Huang, J.C., Hsiao, C.D. (2020) Systematical exploration of the common solvent toxicity at whole organism level by behavioral phenomics in adult zebrafish. Environmental pollution (Barking, Essex : 1987). 266:115239

Malhotra, N., Lee, J.S., Liman, R.A.D., Ruallo, J.M.S., Villaflores, O.B., Ger, T.R., Hsiao. C.D. (2020) Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review. Molecules. 25(14)

Chen, R.Y., Hieu, B.T.N., Audira, G., Lou, B., Lin, M.D., Hsiao, C.D. (2020) Meta-Transcriptomic Analysis of RNAseq Data Reveals Pacu and Loach Fish with Unusually High Levels of Myoglobin Expression in Skeletal Muscles. Animals : an open access journal from MDPI. 10(7)

Hussain, A., Audira, G., Siregar, P., Lin, Y.C., Villalobos, O., Villaflores, O., Wang, W.D., Hsiao, C.D. (2020) Waterborne Exposure of Paclobutrazol at Environmental Relevant Concentration Induce Locomotion Hyperactivity in Larvae and Anxiolytic Exploratory Behavior in Adult Zebrafish. International Journal of Environmental Research and Public Health. 17(13):

Chen, R.Y., Lin, C.J., Liang, S.T., Villalobos, O., Villaflores, O.B., Lou, B., Lai, Y.H., Hsiao, C.D. (2020) UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Animals : an open access journal from MDPI. 10(6):

Balitaan, J.N.I., Hsiao, C.D., Yeh, J.M., Santiago, K.S. (2020) Innovation inspired by nature: Biocompatible self-healing injectable hydrogels based on modified-β-chitin for wound healing. International journal of biological macromolecules. 162:723-736

Malhotra, N., Audira, G., Chen, J.R., Siregar, P., Hsu, H.S., Lee, J.S., Ger, T.R., Hsiao, C.D. (2020) Surface Modification of Magnetic Nanoparticles by Carbon-Coating Can Increase Its Biosafety: Evidences from Biochemical and Neurobehavioral Tests in Zebrafish. Molecules. 25(9):

Lin, Y.N., Audira, G., Malhotra, N., Ngoc Anh, N.T., Siregar, P., Lu, J.H., Lee, H., Hsiao, C.D. (2020) A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory. International Journal of Molecular Sciences. 21(8):

Bui Thi, N.H., Nguyen Thi, N.A., Audira, G., Siregar, P., Liang, S.T., Huang, J.C., Hsiao, C.D. (2020) Chronic Exposure to Low Concentration Lead Chloride-Induced Anxiety and Loss of Aggression and Memory in Zebrafish. International Journal of Molecular Sciences. 21(5):

Ngoc Hieu, B.T., Ngoc Anh, N.T., Audira, G., Juniardi, S., Liman, R.A.D., Villaflores, O.B., Lai, Y.H., Chen, J.R., Liang, S.T., Huang, J.C., Hsiao, C.D. (2020) Development of a Modified Three-Day T-maze Protocol for Evaluating Learning and Memory Capacity of Adult Zebrafish. International Journal of Molecular Sciences. 21(4):

Sarasamma, S., Audira, G., Siregar, P., Malhotra, N., Lai, Y.H., Liang, S.T., Chen, J.R., Chen, K.H., Hsiao, C.D. (2020) Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure. International Journal of Molecular Sciences. 21(4):

Li, X., Li, C., Zhu, Y., Shi, Y., Zhang, X., Zhang, S., Wang, L., Lin, H.W., Hou, H., Hsiao, C.D., Han, L., Liu, K. (2020) Lipids Fingerprinting of Different Materials Sources by UPLC-Q-Exactive Orbitrap/MS Approach and Their Zebrafish-based Activities Comparison. Journal of Agricultural and Food Chemistry. 68(7):2007-2015

Song, Z., Zhang, Y., Zhang, H., Rajendran, R.S., Wang, R., Hsiao, C.D., Li, J., Xia, Q., Liu, K. (2019) Isoliquiritigenin triggers developmental toxicity and oxidative stress-mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway. Chemosphere. 246:125727

Sarasamma, S., Audira, G., Samikannu, P., Juniardi, S., Siregar, P., Hao, E., Chen, J.R., Hsiao, C.D. (2019) Behavioral Impairments and Oxidative Stress in the Brain, Muscle, and Gill Caused by Chronic Exposure of C₇₀ Nanoparticles on Adult Zebrafish. International Journal of Molecular Sciences. 20(22):

Liang, S.T., Chen, J.R., Tsai, J.J., Lai, Y.H., Hsiao, C.D. (2019) Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish. International Journal of Molecular Sciences. 20(15)

Huo, J., Yu, Q., Zhang, Y., Liu, K., Hsiao, C.D., Jiang, Z., Zhang, L. (2019) Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish. Journal of applied toxicology : JAT. 39(11):1532-1540

Zhang, Y., Cen, J., Jia, Z., Hsiao, C.D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L., Liu, K. (2019) Correction for Zhang et al., "Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish". Antimicrobial Agents and Chemotherapy. 63(7)

Audira, G., Sampurna, B.P., Juniardi, S., Liang, S.T., Lai, Y.H., Han, L., Hsiao, C.D. (2019) Establishing simple image-based methods and cost-effective instrument for toxicity assessment on circadian rhythm dysregulation in fish. Biology Open. 8(6):

Sampurna, B.P., Santoso, F., Lee, J.H., Yu, W.H., Wu, C.C., Audira, G., Juniardi, S., Chen, J.R., Lin, Y.T., Hsiao, C.D. (2019) Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish. Cells. 8(6)

Malhotra, N., Chen, J.R., Sarasamma, S., Audira, G., Siregar, P., Liang, S.T., Lai, Y.H., Lin, G.M., Ger, T.R., Hsiao, C.D. (2019) Ecotoxicity Assessment of Fe₃O₄ Magnetic Nanoparticle Exposure in Adult Zebrafish at an Environmental Pertinent Concentration by Behavioral and Biochemical Testing. Nanomaterials (Basel, Switzerland). 9(6):

Liang, S.T., Audira, G., Juniardi, S., Chen, J.R., Lai, Y.H., Du, Z.C., Lin, D.S., Hsiao, C.D. (2019) Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities. Cells. 8(5):

Jia, Z.L., Cen, J., Wang, J.B., Zhang, F., Xia, Q., Wang, X., Chen, X.Q., Wang, R.C., Hsiao, C.D., Liu, K.C., Zhang, Y. (2019) Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. 227:541-550

Zhang, Y., Cen, J., Jia, Z., Hsiao, C.D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L., Liu, K. (2019) Hepatotoxicity induced by Isoniazid/Lipopolysaccharide through ERS-, autophagy- and apoptosis pathway in zebrafish. Antimicrobial Agents and Chemotherapy. 63(5):

Audira, G., Sarasamma, S., Chen, J.R., Juniardi, S., Sampurna, B.P., Liang, S.T., Lai, Y.H., Lin, G.M., Hsieh, M.C., Hsiao, C.D. (2018) Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation. International Journal of Molecular Sciences. 19(12):

Jin, M., Xiao, Z., Zhang, S., Men, X., Li, X., Zhang, B., Zhou, T., Hsiao, C.D., Liu, K. (2018) Possible involvement of Fas/FasL-dependent apoptotic pathway in α-bisabolol induced cardiotoxicity in zebrafish embryos. Chemosphere. 219:557-566

Sarasamma, S., Lai, Y.H., Liang, S.T., Liu, K., Hsiao, C.D. (2018) The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities. International Journal of Molecular Sciences. 19(12)

Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Lai, Y.H., Hao, E., Chen, J.R., Hsiao, C.D. (2018) Evaluation of the Effects of Carbon 60 Nanoparticle Exposure to Adult Zebrafish: A Behavioral and Biochemical Approach to Elucidate the Mechanism of Toxicity. International Journal of Molecular Sciences. 19(12):

Sarasamma, S., Audira, G., Juniardi, S., Sampurna, B.P., Liang, S.T., Hao, E., Lai, Y.H., Hsiao, C.D. (2018) Zinc Chloride Exposure Inhibits Brain Acetylcholine Levels, Produces Neurotoxic Signatures, and Diminishes Memory and Motor Activities in Adult Zebrafish. International Journal of Molecular Sciences. 19(10)

Xiong, X.Y., Liu, Y., Shan, L.T., Xu, Y.Q., Liang, J., Lai, Y.H., Hsiao, C.D. (2018) Evaluation of collagen mixture on promoting skin wound healing in zebrafish caused by acetic acid administration. Biochemical and Biophysical Research Communications. 505(2):516-522

Hsieh, F.C., Lu, Y.F., Liau, I., Chen, C.C., Cheng, C.M., Hsiao, C.D., Hwang, S.L. (2018) Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Scientific Reports. 8:7856

Sampurna, B.P., Audira, G., Juniardi, S., Lai, Y.H., and Hsiao, C.D. (2018) A Simple ImageJ-Based Method to Measure Cardiac Rhythm in Zebrafish Embryos. Inventions. 3(2)

Audira, G., Sampurna, B.P., Juniardi, S., Liang, S.T., Lai, Y.H., and Hsiao, C.D. (2018) A Simple Setup to Perform 3D Locomotion Tracking in Zebrafish by Using a Single Camera. Inventions. 3(1)

Schepis, A., Barker, A., Srinivasan, Y., Balouch, E., Zheng, Y., Lam, I., Clay, H., Hsiao, C.D., Coughlin, S.R. (2018) Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. The Journal of cell biology. 217(3):1097-1112

Chen, J.R., Lai, Y.H., Tsai, J.J., Hsiao, C.D. (2017) Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization. Molecules. 22(12)

Sarasamma, S., Varikkodan, M.M., Liang, S.T., Lin, Y.C., Wang, W.P., Hsiao, C.D. (2017) Zebrafish: A Premier Vertebrate Model for Biomedical Research in Indian Scenario. Zebrafish. 14(6):589-605

Zhang, Y., Han, L., He, Q., Chen, W., Sun, C., Wang, X., Chen, X., Wang, R., Hsiao, C.D., Liu, K. (2017) A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish. Journal of Pharmacological and Toxicological Methods. 84:102-110

Zhang, Y., Liu, K., Hassan, H.M., Guo, H., Ding, P., Han, L., He, Q., Chen, W., Hsiao, C.D., Zhang, L., Jiang, Z. (2016) L-FABP-deficiency provoked oxidative stress, inflammation and apoptosis-mediated hepatotoxicity induced by pyrazinamide on zebrafish larvae. Antimicrobial Agents and Chemotherapy. 60(12):7347-7356

Sun, G., Liu, K., Wang, X., Liu, X., He, Q., Hsiao, C.D. (2015) Identification and Expression Analysis of Zebrafish (Danio rerio) E-Selectin during Embryonic Development. Molecules. 20:18539-18550

Chang, T.Y., Huang, T.S., Wang, H.W., Chang, S.J., Lo, H.H., Chiu, Y.L., Wang, Y.L., Hsiao, C.D., Tsai, C.H., Chan, C.H., You, R.I., Wu, C.H., Tsai, T.N., Cheng, S.M., Cheng, C.C. (2014) miRNome traits analysis on endothelial lineage cells discloses biomarker potential circulating microRNAs which affect progenitor activities. BMC Genomics. 15:802

Huang, S.Y., Feng, C.W., Hung, H.C., Chakraborty, C., Chen, C.H., Chen, W.F., Jean, Y.H., Wang, H.M., Sung, C.S., Sun, Y.M., Wu, C.Y., Liu, W., Hsiao, C.D., Wen, Z.H. (2014) A Novel Zebrafish Model to Provide Mechanistic Insights into the Inflammatory Events in Carrageenan-Induced Abdominal Edema. PLoS One. 9:e104414

Chen, C.H., Lin, D.S., Cheng, C.W., Lin, C.J., Lo, Y.K., Yen, C.C., Lee, A.Y., Hsiao, C.D. (2014) Cdc6 cooperates with c-Myc to promote genome instability and EMT in zebrafish. Oncotarget. 5(15):6300-11

Feng, C.W., Wen, Z.H., Huang, S.Y., Hung, H.C., Chen, C.H., Yang, S.N., Chen, N.F., Wang, H.M., Hsiao, C.D., Chen, W.F. (2014) Effects of 6-Hydroxydopamine Exposure on Motor Activity and Biochemical Expression in Zebrafish (Danio Rerio) Larvae. Zebrafish. 11(3):227-39

Chen, S.Y., Shih, H.Y., Lin, S.J., Hsiao, C.D., Li, Z.C., and Cheng, Y.C. (2013) Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science. 126(Pt 24):5626-34

Shih, D.F., Hsiao, C.D., Min, M.Y., Lai, W.S., Yang, C.W., Lee, W.T., and Lee, S.J. (2013) Aromatic L-Amino Acid Decarboxylase (AADC) Is Crucial for Brain Development and Motor Functions. PLoS One. 8(8):e71741

Lin, C.Y., Huang, C.C., Wang, W.D., Hsiao, C.D., Cheng, C.F., Wu, Y.T., Lu, Y.F., and Hwang, S.P. (2013) Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One. 8(7):e69788

Chu, C.Y., Chen, C.F., Rajendran, R.S., Shen, C.N., Chen, T.H., Yen, C.C., Chuang, C.K., Lin, D.S., and Hsiao, C.D. (2012) Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7(5):e36474

Yeh, C.M., Liu, Y.C., Chang, C.J., Lai, S.L., Hsiao, C.D., and Lee, S.J. (2011) Ptenb Mediates Gastrulation Cell Movements via Cdc42/AKT1 in Zebrafish. PLoS One. 6(4):e18702

Huang, S.H., Hsiao, C.D., Lin, D.S., Chow, C.Y., Chang, C.J., and Liau, I. (2011) Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. PLoS One. 6(9):e24764

Liu, D.W., Hsu, C.H., Tsai, S.M., Hsiao, C.D., and Wang, W.P. (2011) A variant of fibroblast growth factor receptor 2 (fgfr2) regulates left-right asymmetry in zebrafish. PLoS One. 6(7):e21793

Chen, C.F., Chu, C.Y., Chen, T.H., Lee, S.J., Shen, C.N., and Hsiao, C.D. (2011) Establishment of a transgenic zebrafish line for superficial skin ablation and functional validation of apoptosis modulators in vivo. PLoS One. 6(5):e20654

Chang, W.J., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2009) The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(4):R1192-R1201

Tseng, D.Y., Chou, M.Y., Tseng, Y.C., Hsiao, C.D., Huang, C.J., Kaneko, T., and Hwang, P.P. (2009) Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. American journal of physiology. Regulatory, integrative and comparative physiology. 296(3):R549-R557

Chou, M.Y., Hsiao, C.D., Chen, S.C., Chen, I.W., Liu, S.T., and Hwang, P.P. (2008) Effects of hypothermia on gene expression in zebrafish gills: upregulation in differentiation and function of ionocytes as compensatory responses. The Journal of experimental biology. 211(Pt 19):3077-3084

Lin, T.Y., Liao, B.K., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2008) Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 294(5):C1250-C1260

Hsiao, C.D., You, M.S., Guh, Y.J., Ma, M., Jiang, Y.J., and Hwang, P.P. (2007) A Positive Regulatory Loop between foxi3a and foxi3b Is Essential for Specification and Differentiation of Zebrafish Epidermal Ionocytes. PLoS One. 2(1):e302

Hsiao, C.D., Ekker, M., and Tsai, H.J. (2003) Skin-specific expression of ictacalcin, a homolog of the S100 genes, during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(4):745-750

Hsiao, C.-D. and Tsai, H.-J. (2003) Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivo. Developmental Biology. 262:313-323

Hsiao, C.-D., Tsai, W.-Y., Horng, L.-S., and Tsai, H.-J. (2003) Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 227:266-279

Hsiao, C.D., Tsai, W.Y., and Tsai, H.J. (2002) Isolation and expression of two zebrafish homologues of parvalbumin genes related to chicken CPV3 and mammalian oncomodulin. Mechanisms of Development. (Suppl.) 119:S161-S166

Hsiao, C.D., Hsieh, F.J., and Tsai, H.J. (2001) Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 220(4):323-336

NON-ZEBRAFISH PUBLICATIONS
Audira G, Siregar P, Chen KHC, Roldan MJM, Huang JC*, Lai HT*, Hsiao CD*. 2021. Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics. IJMS 22(11), 5686.

Siregar P, Suryanto ME, Chen KHC, Huang JC, Chen HM, Kurnia KA, Santoso F, Hussain A, Bui TNH, Saputra F, Audira G, Roldan MJM, Fernandez RA, Macabeo APG*, Lai HT*, Hsiao CD*. 2021. Exploiting the freshwater shrimp Neocaridina denticulata as aquatic invertebrate model to evaluate non-targeted pesticide induced toxicity by investigating physiologic and biochemical parameters. Antioxidants 10(3), 391.

Malhotra N, Hsu HS, Liang ST, Roldan MJM, Lee JS*, Ger TR*, Hsiao CD*. 2020. An Updated Review of Toxicity Effect of the Rare Earth Elements (REEs) on Aquatic Organisms. Animals 10(9):1663.

Santoso F, Krylov VV, Castillo AL, Saputra F, Chen HM, Lai HT*, Hsiao CD*. 2020. Cardiovascular Performance Measurement in Water Fleas by Utilizing High-speed Videography and ImageJ Software and Its Application for Pesticide Toxicity Assessment. Animals 10(9):1587.

Malhotra N, Villaflores OB, Audira G, Siregar P, Lee JS*, Ger TR*, Hsiao CD*. 2020. Toxicity Studies on Graphene-based Nanomaterials in Aquatic Organisms: Current Understanding. Molecules 25(16): 3618.

Malhotra N, Lee JS, Liman RAD, Ruallo JMS, Villaflores OB, Ger TR*, Hsiao CD*. 2020. Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review. Molecules 25(14), 3159.

Chen RY, Bui TNH, Audira G, Lou B*, Lin MD*, Hsiao CD*. 2020. Meta-transcriptomic Analysis of RNAseq Data Reveals Pacu and Loach Fish with Unusually High Levels of Myoglobin Expression in Skeletal Muscles. Animals 10, 1130.

Malhotra N, Ger TR, Uapipatanakul B, Huang JC, Chen KHC*, Hsiao CD*. 2020. Review of Copper and Copper Nanoparticle Toxicity in Fish. Nanomaterials 10,1126.

Hao E, Pang G, Du Z, Lai YH, Chen JR, Xie J, Zhou K, Hou X*, Hsiao CD*, Deng J*. 2019. Peach Kernel Oil Downregulates Expression of Tissue Factor and Reduces Atherosclerosis in ApoE knockout Mice. Int. J. Mol. Sci. 20, 405.

Lin GM, Lai YH, Audira G, Hsiao CD*. 2017. A simple method to decode the complete 18-5.8-28S rRNA repeated units of green algae by genome skimming. Int. J. Mol. Sci. 18:2341.

Lee SC, Hsiao CD, Wang YS, Lou SW*. 2017. Transcriptome response of previtellogenic ovary in Anguilla japonica after artificial hormone injection. Mar Genomics 35:31-34.

Zhang H, Audira G, Li Y, Xian W*, Varikkodan MM, Hsiao CD*. 2017. Comparative study the expression of calcium cycling genes in Bombay duck (Harpadon nehereus) and beltfish (Trichiurus lepturus) with different swimming activities. Genomics Data. 12: 58-61.

Nie CH, Wan SM, Tomljanovic T, Treer T, Hsiao CD, Wang WM, Gao ZX*. 2017. Comparative proteomics analysis of teleost intermuscular bones and ribs provides insight into their development. BMC Genomics. 18: 147.

Zhang H, Chang CM, Shen KN, Xian W*, Hsiao CD*. 2016. Identification of myogenic regulatory genes in the muscle transcriptome of beltfish (Trichiurus lepturus): a major commercial marine fish species with robust swimming ability. Genomics Data 8: 81-84.

Chen YC, Hsiao CD*, Lin WD, Hu CM, Hwang PP, Ho JM. 2006. ZooDDD: an inter-species database for DDD analysis. Bioinformatics 22:2180-2182 [*Co-first author]