ZFIN Person: Hwang, Pung Pung

ZFIN ID: ZDB-PERS-060601-1

Hwang, Pung Pung

Email:	pphwang@gate.sinica.edu.tw
URL:	http://www.sinica.edu.tw/~mrcell/
Affiliation:	Fish Molecular Physiology Laboratory
Address:	Institute of Cellular and Organismic Biology Academia Sinca Nankang Taipei, 11529 Taiwan
Country:	Taiwan
Phone:	8862-2789-9521
Fax:	8862-2789-9576
ORCID ID:	0000-0002-5534-2812

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Shih, S.W., Yan, J.J., Tsou, Y.L., Lu, S.W., Wang, M.C., Chou, M.Y., Hwang, P.P. (2022) In Vivo Functional Assay in Fish Gills: Exploring Branchial Acid-Excreting Mechanisms in Zebrafish. International Journal of Molecular Sciences. 23(8):

Lin, C.H., Hu, H.J., Chuang, H.J., Tsou, Y.L., Hwang, P.P. (2021) Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 191(5):855-864

Tong, S.K., Lee, H.L., Lee, Y.C., Wu, L.C., Tsou, Y.L., Lu, S.W., Shih, S.W., Hwang, P.P., Chou, M.Y. (2020) Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H⁺-ATPase Rich Ionocytes. International Journal of Molecular Sciences. 21(11)

Chen, Y.C., Liao, B.K., Lu, Y.F., Liu, Y.H., Hsieh, F.C., Hwang, P.P., Hwang, S.L. (2019) Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition. PLoS Genetics. 15:e1008058

Yan, J.J., Hwang, P.P. (2019) Novel Discoveries in Acid-base Regulation and Osmoregulation: A Review of Selected Hormonal Actions in Zebrafish and Medaka. General and comparative endocrinology. 277:20-29

Lin, L.Y., Yeh, Y.H., Hung, G.Y., Lin, C.H., Hwang, P.P., Horng, J.L. (2018) Role of Calcium-Sensing Receptor in Mechanotransducer-Channel-Mediated Ca²⁺ Influx in Hair Cells of Zebrafish Larvae.. Frontiers in Physiology. 9:649

Guh, Y.J., Hwang, P.P. (2018) Corrigendum to "Insights into molecular and cellular mechanisms of hormonal actions on fish ion regulation derived from the zebrafish model" [Gen. Comp. Endocrinol. 251 (2017) 12-20]. General and comparative endocrinology. 259:240

Guh, Y.J., Hwang, P.P. (2017) Insights into molecular and cellular mechanisms of hormonal actions on fish ion regulation derived from the zebrafish model. General and comparative endocrinology. 251:12-20

Lin, C.H., Hu, H.J., Hwang, P.P. (2017) Molecular physiology of the hypocalcemic action of fibroblast growth factor 23 in zebrafish (Danio rerio). Endocrinology. 158(5):1347-1358

Lin, C.H., Hwang, P.P. (2016) The Control of Calcium Metabolism in Zebrafish (Danio rerio). International Journal of Molecular Sciences. 17(11)

Lien, H.W., Yuan, R.Y., Chou, C.M., Chen, Y.C., Hung, C.C., Hu, C.H., Hwang, S.P., Hwang, P.P., Shen, C.N., Chen, C.L., Cheng, C.H., Huang, C.J. (2016) Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α. Scientific Reports. 6:28297

Wang, Y.F., Lafont, A.G., Lee, Y.C., Hwang, P.P. (2016) A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis. Proceedings. Biological sciences. 283(1832)

Lin, C.H., Kuan, W.C., Liao, B.K., Deng, A.N., Tseng, D.Y., Hwang, P.P. (2016) Environmental and cortisol-mediated control of Ca(2+) uptake in tilapia (Oreochromis mossambicus). Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 186(3):323-32

Guh, Y.J., Yang, C.Y., Liu, S.T., Huang, C.J., Hwang, P.P. (2016) Oestrogen-related receptor α is required for transepithelial H+ secretion in zebrafish. Proceedings. Biological sciences. 283(1825):20152582

Lin, C.H., Hu, H.J., Hwang, P.P. (2016) Cortisol regulates sodium homeostasis by stimulating the transcription of sodium-chloride transporter (NCC) in zebrafish (Danio rerio). Molecular and Cellular Endocrinology. 422:93-102

Wu, B.K., Yuan, R.Y., Lien, H.W., Hung, C.C., Hwang, P.P., Chen, R.P., Chang, C.C., Liao, Y.F., Huang, C.J. (2016) Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo. Journal of Biomedical Science. 23:25

Lin, C.H., Shih, T.H., Liu, S.T., Hsu, H.H., Hwang, P.P. (2015) Cortisol Regulates Acid Secretion of H(+)-ATPase-rich Ionocytes in Zebrafish (Danio rerio) Embryos. Frontiers in Physiology. 6:328

Wang, Y.F., Yan, J.J., Tseng, Y.C., Chen, R.D., Hwang, P.P. (2015) Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. International journal of biological sciences. 11:1190-203

Guh, Y.J., Lin, C.H., Hwang, P.P. (2015) Osmoregulation in zebrafish: ion transport mechanisms and functional regulation. EXCLI journal. 14:627-659

Chou, M.Y., Lin, C.H., Chao, P.L., Hung, J.C., Cruz, S.A., Hwang, P.P. (2015) Stanniocalcin-1 Controls Ion Regulation Functions of Ion-transporting Epithelium Other than Calcium Balance. International journal of biological sciences. 11:122-32

Hsu, H.H., Lin, L.Y., Tseng, Y.C., Horng, J.L., Hwang, P.P. (2014) A new model for fish ion regulation: identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes). Cell and tissue research. 357(1):225-43

Guh, Y.J., Tseng, Y.C., Yang, C.Y., and Hwang, P.P. (2014) Endothelin-1 regulates H+-ATPase-dependent transepithelial H+ secretion in zebrafish. Endocrinology. 155(5):1728-37

Han, H.W., Chou, C.M., Chu, C.Y., Cheng, C.H., Yang, C.H., Hung, C.C., Hwang, P.P., Lee, S.J., Liao, Y.F., and Huang, C.J. (2014) The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PLoS One. 9(1):e86345

Lin, C.H., Su, C.H., and Hwang, P.P. (2014) Calcium-sensing receptor mediates Ca2+ homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 155(1):56-67

Cruz, S.A., Lin, C.H., Chao, P.L., and Hwang, P.P. (2013) Glucocorticoid receptor, but not mineralocorticoid receptor, mediates cortisol regulation of epidermal ionocyte development and ion transport in zebrafish (danio rerio). PLoS One. 8(10):e77997

Lien, H.W., Yang, C.H., Cheng, C.H., Hung, C.C., Liao, W.H., Hwang, P.P., Han, Y.S., and Huang, C.J. (2013) A Novel Zinc Finger Protein 219-like (ZNF219L) is Involved in the Regulation of Collagen Type 2 Alpha 1a (col2a1a) Gene Expression in Zebrafish Notochord. International journal of biological sciences. 9(9):872-886

Hwang, P.P., and Chou, M.Y. (2013) Zebrafish as an animal model to study ion homeostasis. Pflugers Archiv : European journal of physiology. 465(9):1233-1247

Chang, W.J., Wang, Y.F., Hu, H.J., Wang, J.H., Lee, T.H., and Hwang, P.P. (2013) Compensatory regulation of Na+ absorption by Na+/H+ exchanger and Na+-Cl- cotransporter in zebrafish (Danio rerio). Frontiers in Zoology. 10(1):46

Liao, W.H., Cheng, C.H., Hung, K.S., Chiu, W.T., Chen, G.D., Hwang, P.P., Hwang, S.P., Kuan, Y.S., and Huang, C.J. (2013) Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cellular and molecular life sciences : CMLS. 70(13):2367-81

Cruz, S.A., Chao, P.L., and Hwang, P.P. (2013) Cortisol promotes differentiation of epidermal ionocytes through Foxi3 transcription factors in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 164(1):249-257

Dymowska, A., Hwang, P.P., and Goss, G.G. (2012) Structure and function of ionocytes in the freshwater fish gill. Respiratory Physiology & Neurobiology. 184(3):282-292

Lin, C.H., Su, C.H., Tseng, D.Y., Ding, F.C., and Hwang, P.P. (2012) Action of Vitamin D and the Receptor, VDRa, in Calcium Handling in Zebrafish (Danio rerio). PLoS One. 7(9):e45650

Shih, T.H., Horng, J.L., Liu, S.T., Hwang, P.P., and Lin, L.Y. (2012) Rhcg1 and NHE3b are involved in ammonium-dependent sodium uptake by zebrafish larvae acclimated to low-sodium water. American journal of physiology. Regulatory, integrative and comparative physiology. 302(1):R84-93

Chang, W.J., and Hwang, P.P. (2011) Development of zebrafish epidermis. Birth defects research. Part C, Embryo today : reviews. 93(3):205-214

Chou, M.Y., Hung, J.C., Wu, L.C., Hwang, S.P., and Hwang, P.P. (2011) Isotocin controls ion regulation through regulating ionocyte progenitor differentiation and proliferation. Cellular and molecular life sciences : CMLS. 68(16):2797-809

Lafont, A.G., Wang, Y.F., Chen, G.D., Liao, B.K., Tseng, Y.C., Huang, C.J., and Hwang, P.P. (2011) Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 26(5):1072-1083

Tseng, Y.C., Chen, R.D., Lucassen, M., Schmidt, M.M., Dringen, R., Abele, D., and Hwang, P.P. (2011) Exploring Uncoupling Proteins and Antioxidant Mechanisms under Acute Cold Exposure in Brains of Fish. PLoS One. 6(3):e18180

Lee, Y.C., Yan, J.J., Cruz, S., Horng, J.L., and Hwang, P.P. (2011) Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 300(2):C295-C307

Tseng, Y.C., Lee, J.R., Lee, S.J., and Hwang, P.P. (2011) Functional analysis of the glucose transporters-1, -6, and -13.1 expressed by zebrafish epithelial cells. American journal of physiology. Regulatory, integrative and comparative physiology. 300(2):R321-R329

Huang, K.Y., Chen, G.D., Cheng, C.H., Liao, K.Y., Hung, C.C., Chang, G.D., Hwang, P.P., Lin, S.Y., Tsai, M.C., Khoo, K.H., Lee, M.T., and Huang, C.J. (2011) Phosphorylation of the Zebrafish M6Ab at Serine 263 Contributes to Filopodium Formation in PC12 Cells and Neurite Outgrowth in Zebrafish Embryos. PLoS One. 6(10):e26461

Lin, C.H., Tsai, I.L., Su, C.H., Tseng, D.Y., and Hwang, P.P. (2011) Reverse Effect of Mammalian Hypocalcemic Cortisol in Fish: Cortisol Stimulates Ca Uptake via Glucocorticoid Receptor-Mediated Vitamin D(3) Metabolism. PLoS One. 6(8):e23689

Chen, Y.C., Wu, B.K., Chu, C.Y., Cheng, C.H., Han, H.W., Chen, G.D., Lee, M.T., Hwang, P.P., Kawakami, K., Chang, C.C., and Huang, C.J. (2010) Identification and characterization of alternative promoters of zebrafish Rtn-4/Nogo genes in cultured cells and zebrafish embryos. Nucleic acids research. 38(14):4635-4650

Thermes, V., Lin, C.C., and Hwang, P.P. (2010) Expression of Ol-foxi3 and Na(+)/K(+)-ATPase in ionocytes during the development of euryhaline medaka (Oryzias latipes) embryos. Gene expression patterns : GEP. 10(4-5):185-192

Cruz, S.A., Tseng, Y.C., Kaiya, H., Hwang, P.P., Cruz, S.A., Hwang, P.P., Kaiya, H., Tseng, Y.C., and Hwang, P.P. (2010) Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 156(2):190-200

Tseng, Y.C., Chen, R.D., Lee, J.R., Liu, S.T., Lee, S.J., and Hwang, P.P. (2009) Specific Expression and Regulation of Glucose Transporters in Zebrafish Ionocytes. American journal of physiology. Regulatory, integrative and comparative physiology. 297(2):R275-R290

Hwang, P.P. (2009) Ion uptake and acid secretion in zebrafish (Danio rerio). The Journal of experimental biology. 212(Pt 11):1745-1752

Liao, B.K., Chen, R.D., and Hwang, P.P. (2009) Expression regulation of Na+-K+-ATPase {alpha}1-subunit subtypes in zebrafish gill ionocytes. American journal of physiology. Regulatory, integrative and comparative physiology. 296(6):R1897-R1906

Wang, Y.F., Tseng, Y.C., Yan, J.J., Hiroi, J., and Hwang, P.P. (2009) Role of SLC12A10.2, a Na-Cl cotransporter-like protein, in a Cl uptake mechanism in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1650-R1660

Chang, W.J., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2009) The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(4):R1192-R1201

Horng, J.L., Lin, L.Y., and Hwang, P.P. (2009) Functional regulation of H+-ATPase-rich cells in zebrafish embryos acclimated to an acidic environment. American journal of physiology. Cell physiology. 296(4):C682-C692

Tseng, D.Y., Chou, M.Y., Tseng, Y.C., Hsiao, C.D., Huang, C.J., Kaneko, T., and Hwang, P.P. (2009) Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. American journal of physiology. Regulatory, integrative and comparative physiology. 296(3):R549-R557

Cruz, S., Shiao, J.C., Liao, B.K., Huang, C.J., and Hwang, P.P. (2009) Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear. The Journal of experimental biology. 212(Pt 5):639-647

Shih, T.H., Horng, J.L., Hwang, P.P., and Lin, L.Y. (2008) Ammonia excretion by the skin of zebrafish (Danio rerio) larvae. American journal of physiology. Cell physiology. 295(6):C1625-C1632

Lee, S.J., Chan, T.H., Chen, T.C., Liao, B.K., Hwang, P.P., and Lee, H. (2008) LPA1 is essential for lymphatic vessel development in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 22(10):3706-3715

Chou, M.Y., Hsiao, C.D., Chen, S.C., Chen, I.W., Liu, S.T., and Hwang, P.P. (2008) Effects of hypothermia on gene expression in zebrafish gills: upregulation in differentiation and function of ionocytes as compensatory responses. The Journal of experimental biology. 211(Pt 19):3077-3084

Lin, T.Y., Liao, B.K., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2008) Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 294(5):C1250-C1260

Yan, J.J., Chou, M.Y., Kaneko, T., and Hwang, P.P. (2007) Gene expression of Na+/H+ exchanger in zebrafish H+-ATPase-rich cells during acclimation to low-Na+ and acidic environments. American journal of physiology. Cell physiology. 293(6):C184-C1823

Liao, B.K., Deng, A.N., Chen, S.C., Chou, M.Y., and Hwang, P.P. (2007) Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. BMC Genomics. 8(1):354

Horng, J.L., Lin, L.Y., Huang, C.J., Katoh, F., Kaneko, T., and Hwang, P.P. (2007) Knockdown of V-ATPase subunit A ({alpha}tp6v1{alpha}) impairs acid secretion and ion balance in zebrafish Danio rerio. American journal of physiology. Regulatory, integrative and comparative physiology. 292(5):R2068-2076

Hsiao, C.D., You, M.S., Guh, Y.J., Ma, M., Jiang, Y.J., and Hwang, P.P. (2007) A Positive Regulatory Loop between foxi3a and foxi3b Is Essential for Specification and Differentiation of Zebrafish Epidermal Ionocytes. PLoS One. 2(1):e302

Lin, L.Y., Horng, J.L., Kunkel, J.G., and Hwang, P.P. (2006) Proton pump-rich cell is secreting acid in skin of zebrafish larvae (Danio rerio). American journal of physiology. Cell physiology. 290(2):C371-C378

Pan, T.C., Liao, B.K., Huang, C.J., Lin, L.Y., and Hwang, P.P. (2005) Epithelial Ca2+ Channel Expression and Ca2+ uptake in Developing Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 289(4):R1202-1211

Chen, Y.-Y., Lu, F.-I., and Hwang, P.-P. (2003) Comparisons of calcium regulation in fish larvae. The Journal of experimental zoology. 295A(2):127-135

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