ZFIN ID: ZDB-PERS-050929-6
Reimer, Michell M.
Email: michell.reimer@crt-dresden.de
Affiliation: Reimer Lab
Address: Technische Universität Dresden DFG-Center for Regenerative Therapies Dresden Cluster of Excellence at the TU Dresden Fetscherstraße 105 01307 Dresden, Germany
Country: United Kingdom
Phone: +49 (0) 351 458 82312

My research interest is to understand the mechanisms of developmental and regenerative processes in the vertebrate spinal cord. Specifically, I am investigating motor neuron replacement and the beneficial roles of oligodendroglia in regeneration of the lesioned spinal cord.

My aim is to identify signal transduction pathways which play key roles in the functional recovery after spinal cord lesions.
For my experiments I use zebrafish. They are ideal to study spinal cord injury in an adult vertebrate as they successfully regain function after complete spinal cord transection, accompanied by axonal and neuronal regeneration and a complex microglial/immune system response.

Tsata, V., Kroehne, V., Wehner, D., Rost, F., Lange, C., Hoppe, C., Kurth, T., Reinhardt, S., Petzold, A., Dahl, A., Loeffler, M., Reimer, M.M., Brand, M. (2020) Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord. Development (Cambridge, England). 147(24):
Tsata, V., Kroehne, V., Reinhardt, S., El-Armouche, A., Brand, M., Wagner, M., Reimer, M.M. (2019) Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Frontiers in Cellular Neuroscience. 13:102
Reinhardt, L., Kordes, S., Reinhardt, P., Glatza, M., Baumann, M., Drexler, H.C.A., Menninger, S., Zischinsky, G., Eickhoff, J., Fröb, C., Bhattarai, P., Arulmozhivarman, G., Marrone, L., Janosch, A., Adachi, K., Stehling, M., Anderson, E.N., Abo-Rady, M., Bickle, M., Pandey, U.B., Reimer, M.M., Kizil, C., Schöler, H.R., Nussbaumer, P., Klebl, B., Sterneckert, J.L. (2019) Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo. Stem Cell Reports. 12(3):502-517
Kroehne, V., Tsata, V., Marrone, L., Froeb, C., Reinhardt, S., Gompf, A., Dahl, A., Sterneckert, J., Reimer, M.M. (2017) Primary Spinal OPC Culture System from Adult Zebrafish to Study Oligodendrocyte Differentiation In Vitro.. Frontiers in Cellular Neuroscience. 11:284
Wehner, D., Tsarouchas, T.M., Michael, A., Haase, C., Weidinger, G., Reimer, M.M., Becker, T., Becker, C.G. (2017) Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nature communications. 8:126
Mysiak, K.S., Barreiro-Iglesias, A., Reimer, M.M., Scott, A.L., Yang, Y., Becker, T., Becker, C.G. (2015) Serotonin promotes motor neuron development and adult regeneration in zebrafish. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 47:51
Barreiro-Iglesias, A., Mysiak, K.S., Scott, A.L., Reimer, M.M., Yang, Y., Becker, C.G., Becker, T. (2015) Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. Cell Reports. 13:924-932
Wishart, T.M., Mutsaers, C.A., Riessland, M., Reimer, M.M., Hunter, G., Hannam, M.L., Eaton, S.L., Fuller, H.R., Roche, S.L., Somers, E., Morse, R., Young, P.J., Lamont, D.J., Hammerschmidt, M., Joshi, A., Hohenstein, P., Morris, G.E., Parson, S.H., Skehel, P.A., Becker, T., Robinson, I.M., Becker, C.G., Wirth, B., Gillingwater, T.H. (2014) Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote spinal muscular atrophy. J. Clin. Invest.. 124:1821-34
Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y.C., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T., and Becker, C.G. (2013) Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration. Developmental Cell. 25(5):478-491
Zhong, Z., Ohnmacht, J., Reimer, M.M., Bach, I., Becker, T., and Becker, C.G. (2012) Chondrolectin mediates growth cone interactions of motor axons with an intermediate target. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(13):4426-4439
Wyatt, C., Ebert, A., Reimer, M.M., Rasband, K., Hardy, M., Chien, C.B., Becker, T., and Becker, C.G. (2010) Analysis of the astray/robo2 Zebrafish Mutant Reveals that Degenerating Tracts Do Not Provide Strong Guidance Cues for Regenerating Optic Axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(41):13838-13849
Reimer, M.M., Kuscha, V., Wyatt, C., Sörensen, I., Frank, R.E., Knüwer, M., Becker, T., and Becker, C.G. (2009) Sonic hedgehog is a polarized signal for motor neuron regeneration in adult zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48):15073-15082
Reimer, M.M., Sörensen, I., Kuscha, V., Frank, R.E., Liu, C., Becker, C.G., and Becker, T. (2008) Motor neuron regeneration in adult zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(34):8510-8516
Reimer, M.M. (2008) Motor neuron differentiation in the developing and the regenerating adult spinal cord of zebrafish Danio rerio (Hamilton, 1822). Ph.D. Thesis.
Feldner, J., Reimer, M.M., Schweitzer, J., Wendik, B., Meyer, D., Becker, T., and Becker, C.G. (2007) PlexinA3 restricts spinal exit points and branching of trunk motor nerves in embryonic zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(18):4978-4983

McQueen J., Reimer M.M., Holland P.R., Manso Sanz Y., McLaughlin M., Fowler J.H., Horsburgh K. (2013) Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion. (PLoS ONE 9(2): e87227. doi:10.1371/journal.pone.0087227)

Reimer M.M., McQueen J., Searcy L., Scullion G., Zonta B., Desmazieres A., Holland P.R., Smith J., Gliddon C., Wood E., Herzyk P., Brophy P., McCulloch J., Horsburgh K. (2011) Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion
J Neurosci. 31:18185-94.

Horsburgh K., Reimer M.M., Holland P., Chen G., Scullion G., Fowler J.H. (2011)
Axon-glial disruption: The link between vascular disease and Alzheimer’s disease? (Review) Biochem. Soc. Trans. 1;39(4):881-5.

Reimer M.M.
Motor neuron regeneration in the spinal cord of adult zebrafish (ISBN 978-3-8381-1706-5) Suedwestdeutscher Verlag fuer Hochschulschriften (2010)

Siebert S.*, Thomsen, S.*, Reimer M.M., Bosch T.C.G. (2005) Control of foot differentiation in Hydra: Phylogenetic footprinting indicates interaction of head, bud and foot patterning systems.
Mech. Dev. 122:998-1007. * These authors contributed equally