ZFIN ID: ZDB-PERS-041109-1
Liu, Yi-wen
Email: dlslys@thu.edu.tw
Address: Department of Life Science Tunghai University Room 106, Basic Science Building, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, Taiwan
Phone: +886-4-23590121 ext 32432
Fax: +886-4-23590296

Our team is interested in the molecular and cellular mechanisms that govern the interrenal gland development. At the present stage, we are focused on the following issues: (1) How various signaling transduction pathways orchestrate to regulate specification and growth of the steroidogenic interrenal tissue; (2) how steroidogenic and chromaffin cell lineages develop and integrate into a functional interrenal organ; (3) how the blood vessel and its extracellular microenvironment direct morphogenetic movements of the interrenal steroidogenic cells.

Lu, S., Lyu, Z., Wang, Z., Kou, Y., Liu, C., Li, S., Hu, M., Zhu, H., Wang, W., Zhang, C., Kuan, Y.S., Liu, Y.W., Chen, J., Tian, J. (2021) Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 11:2788-2805
Tian, J., Shao, J., Liu, C., Hou, H.Y., Chou, C.W., Shboul, M., Li, G.Q., El-Khateeb, M., Samarah, O.Q., Kou, Y., Chen, Y.H., Chen, M.J., Lyu, Z., Chen, W.L., Chen, Y.F., Sun, Y.H., Liu, Y.W. (2018) Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development. Cellular and molecular life sciences : CMLS. 76(1):163-178
Chao, Y.J., Wu, W.H., Balazova, M., Wu, T.Y., Lin, J., Liu, Y.W., Hsu, Y.H. (2018) Chlorella diet alters mitochondrial cardiolipin contents differentially in organs of Danio rerio analyzed by a lipidomics approach. PLoS One. 13:e0193042
Chou, C.W., Lin, J., Jiang, Y.J., Liu, Y.W. (2017) Aberrant global and Jagged-mediated Notch signaling disrupts segregation between wt1-expressing and steroidogenic tissues in zebrafish. Endocrinology. 158(12):4206-4217
Chou, C.W., Lin, J., Hou, H.Y., Liu, Y.W. (2016) Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish. Journal of visualized experiments : JoVE. (118)
Chou, C.W., Hsu, H.C., You, M.S., Lin, J., Liu, Y.W. (2016) The endoderm indirectly influences morphogenetic movements of the zebrafish head kidney through the posterior cardinal vein and VegfC. Scientific Reports. 6:30677
Chou, C.W., Zhuo, Y.L., Jiang, Z.Y., Liu, Y.W. (2014) The Hemodynamically-Regulated Vascular Microenvironment Promotes Migration of the Steroidogenic Tissue during Its Interaction with Chromaffin Cells in the Zebrafish Embryo. PLoS One. 9:e107997
Huang, M.S., Wang, T.K., Liu, Y.W., Li, Y.T., Chi, T.H., Chou, C.W., Hsieh, M. (2014) Roles of carbonic anhydrase 8 in neuronal cells and zebrafish. Biochimica et biophysica acta. General subjects. 1840(9):2829-2842
Chou, C.W., Chiu, C.H., and Liu, Y.W. (2013) Fibronectin mediates correct positioning of the interrenal organ in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 242(5):432-443
Chiu, C.H., Chou, C.W., Takada, S., and Liu, Y.W. (2012) Development and fibronectin signaling requirements of the zebrafish interrenal vessel. PLoS One. 7(8):e43040
Chou, C.W., Hsu, H.C., Quek, S.I., Chan, W.K., and Liu, Y.W. (2010) Arterial and venous vessels are required for modulating developmental relocalization and laterality of the interrenal tissue in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 239(7):1995-2004
Liu, Y.W. (2007) Interrenal organogenesis in the zebrafish model. Organogenesis. 3(1):44-48
Liu, Y.W., and Guo, L. (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Developmental Biology. 297(1):44-58
Liu, Y.W., Gao, W., Teh, H.L., Tan, J.H., and Chan, W.K. (2003) Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium. Molecular and cellular biology. 23(20):7243-7255
Chai, C., Liu, Y., and Chan, W.K. (2003) Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ. Developmental Biology. 260(1):226-244
Liu, Y.-W. and Chan, W.-K. (2002) Thyroid hormones are important for embryonic to larval transitory phase in zebrafish. Differentiation; research in biological diversity. 70(1):36-45
Liu, Y.-W., Lo, L-J., and Chan, W.-K. (2000) Temporal expression and T3 induction of thyroid hormone receptors alpha1 and beta1 during early embryonic and larval development in zebrafish, Danio rerio. Molecular and Cellular Endocrinology. 159(1-2):187-195

Tsai SH, Liu YW, Tang WC, Zhou ZW, Hwang CY, Hwang GY, Ou BR, Hu CP, Yang VC, Chen JK. (2007) Characterization of porcine arterial endothelial cells cultured on amniotic membrane, a potential matrix for vascular tissue engineering. Biochem Biophys Res Commun. 357(4):984-990