ZFIN ID: ZDB-PERS-030925-7
Ellinor, Patrick
Email: pellinor@partners.org
URL:
Affiliation:
Address: Cardiovascular Research Center Massachusetts General Hospital Mailcode 1494100 149 13th Street, 4th Floor Charlestown, MA 02129 USA
Country:
Phone: (617) 726-4343
Fax: (617) 726-5806
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Yu, M., Georges, A., Tucker, N.R., Kyryachenko, S., Toomer, K., Schott, J.J., Delling, F.N., Fernandez-Friera, L., Solis, J., Ellinor, P.T., Levine, R.A., Slaugenhaupt, S.A., Hagège, A.A., Dina, C., Jeunemaitre, X., Milan, D.J., Norris, R.A., Bouatia-Naji, N. (2019) Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circulation. Genomic and precision medicine. 12:e002497
Morley, M.P., Wang, X., Hu, R., Brandimarto, J., Tucker, N.R., Felix, J.F., Smith, N.L., van der Harst, P., Ellinor, P.T., Margulies, K.B., Musunuru, K., Cappola, T.P. (2019) Cardioprotective Effects of MTSS1 Enhancer Variants. Circulation. 139:2073-2076
Gould, R.A., Aziz, H., Woods, C.E., Seman-Senderos, M.A., Sparks, E., Preuss, C., Wünnemann, F., Bedja, D., Moats, C.R., McClymont, S.A., Rose, R., Sobreira, N., Ling, H., MacCarrick, G., Kumar, A.A., Luyckx, I., Cannaerts, E., Verstraeten, A., Björk, H.M., Lehsau, A.C., Jaskula-Ranga, V., Lauridsen, H., Shah, A.A., Bennett, C.L., Ellinor, P.T., Lin, H., Isselbacher, E.M., Lino Cardenas, C.L., Butcher, J.T., Hughes, G.C., Lindsay, M.E., Baylor-Hopkins Center for Mendelian Genomics, MIBAVA Leducq Consortium, Mertens, L., Franco-Cereceda, A., Verhagen, J.M.A., Wessels, M., Mohamed, S.A., Eriksson, P., Mital, S., Van Laer, L., Loeys, B.L., Andelfinger, G., McCallion, A.S., Dietz, H.C. (2019) ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. Nature Genetics. 51:42-50
Ahlberg, G., Refsgaard, L., Lundegaard, P.R., Andreasen, L., Ranthe, M.F., Linscheid, N., Nielsen, J.B., Melbye, M., Haunsø, S., Sajadieh, A., Camp, L., Olesen, S.P., Rasmussen, S., Lundby, A., Ellinor, P.T., Holst, A.G., Svendsen, J.H., Olesen, M.S. (2018) Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation. Nature communications. 9:4316
Hu, R., Morley, M.P., Brandimarto, J., Tucker, N.R., Parsons, V.A., Zhao, S.D., Meder, B., Katus, H.A., Rühle, F., Stoll, M., Villard, E., Cambien, F., Lin, H., Smith, N.L., Felix, J.F., Vasan, R.S., van der Harst, P., Newton-Cheh, C., Li, J., Kim, C.E., Hakonarson, H., Hannenhalli, S., Ashley, E.A., Moravec, C.S., Tang, W.H.W., Maillet, M., Molkentin, J.D., Ellinor, P.T., Margulies, K.B., Cappola, T.P. (2018) Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects. Circulation. Genomic and precision medicine. 11:e001901
Tucker, N.R., Dolmatova, E.V., Lin, H., Cooper, R.R., Ye, J., Hucker, W.J., Jameson, H.S., Parsons, V.A., Weng, L.C., Mills, R.W., Sinner, M.F., Imakaev, M., Leyton-Mange, J., Vlahakes, G., Benjamin, E.J., Lunetta, K.L., Lubitz, S.A., Mirny, L., Milan, D.J., Ellinor, P.T. (2017) Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential.. Circulation. Cardiovascular genetics. 10(5)
Ye, J., Tucker, N.R., Weng, L.C., Clauss, S., Lubitz, S.A., Ellinor, P.T. (2016) A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a. American journal of human genetics. 99(6):1281-1291
Kiando, S.R., Tucker, N.R., Castro-Vega, L.J., Katz, A., D'Escamard, V., Tréard, C., Fraher, D., Albuisson, J., Kadian-Dodov, D., Ye, Z., Austin, E., Yang, M.L., Hunker, K., Barlassina, C., Cusi, D., Galan, P., Empana, J.P., Jouven, X., Gimenez-Roqueplo, A.P., Bruneval, P., Hyun Kim, E.S., Olin, J.W., Gornik, H.L., Azizi, M., Plouin, P.F., Ellinor, P.T., Kullo, I.J., Milan, D.J., Ganesh, S.K., Boutouyrie, P., Kovacic, J.C., Jeunemaitre, X., Bouatia-Naji, N. (2016) PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance. PLoS Genetics. 12:e1006367
Wang, X., Tucker, N.R., Rizki, G., Mills, R., Krijger, P.H., de Wit, E., Subramanian, V., Bartell, E., Nguyen, X.X., Ye, J., Leyton-Mange, J., Dolmatova, E.V., van der Harst, P., de Laat, W., Ellinor, P.T., Newton-Cheh, C., Milan, D.J., Kellis, M., Boyer, L.A. (2016) Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures. eLIFE. 5
Ma, J.F., Yang, F., Mahida, S.N., Zhao, L., Chen, X., Zhang, M.L., Sun, Z., Yao, Y., Zhang, Y.X., Zheng, G.Y., Dong, J., Feng, M.J., Zhang, R., Sun, J., Li, S., Wang, Q.S., Cao, H., Benjamin, E.J., Ellinor, P.T., Li, Y.G., Tian, X.L. (2016) TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians. Cardiovascular research. 109(3):442-50
Sinner, M.F., Tucker, N.R., Lunetta, K.L., Ozaki, K., Smith, J.G., Trompet, S., Bis, J.C., Lin, H., Chung, M.K., Nielsen, J.B., Lubitz, S.A., Krijthe, B.P., Magnani, J.W., Ye, J., Gollob, M.H., Tsunoda, T., Müller-Nurasyid, M., Lichtner, P., Peters, A., Dolmatova, E., Kubo, M., Smith, J.D., Psaty, B.M., Smith, N.L., Jukema, J.W., Chasman, D.I., Albert, C.M., Ebana, Y., Furukawa, T., MacFarlane, P., Harris, T.B., Darbar, D., Dörr, M., Holst, A.G., Svendsen, J.H., Hofman, A., Uitterlinden, A., Gudnason, V., Isobe, M., Malik, R., Dichgans, M., Rosand, J., Van Wagoner, D.R., METASTROKE Consortium, AFGen Consortium, Benjamin, E.J., Milan, D.J., Melander, O., Heckbert, S., Ford, I., Liu, Y., Barnard, J., Olesen, M.S., Stricker, B.H., Tanaka, T., Kääb, S., Ellinor, P.T. (2014) Integrating Genetic, Transcriptional, and Functional Analyses to Identify Five Novel Genes for Atrial Fibrillation. Circulation. 130(15):1225-35
Lundby, A., Rossin, E.J., Steffensen, A.B., Acha, M.R., Newton-Cheh, C., Pfeufer, A., Lynch, S.N., QT Interval International GWAS Consortium (QT-IGC), Olesen, S.P., Brunak, S., Ellinor, P.T., Jukema, J.W., Trompet, S., Ford, I., Macfarlane, P.W., Krijthe, B.P., Hofman, A., Uitterlinden, A.G., Stricker, B.H., Nathoe, H.M., Spiering, W., Daly, M.J., Asselbergs, F.W., van der Harst, P., Milan, D.J., de Bakker, P.I., Lage, K., Olsen, J.V. (2014) Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Nature Methods. 11(8):868-74
Kolpa, H.J., Peal, D.S., Lynch, S.N., Giokas, A.C., Ghatak, S., Misra, S., Norris, R.A., MacRae, C.A., Markwald, R.R., Ellinor, P., Bischoff, J., and Milan, D.J. (2013) miR-21 represses Pdcd4 during cardiac valvulogenesis. Development (Cambridge, England). 140(10):2172-80
Peal, D.S., Mills, R.W., Lynch, S.N., Mosley, J.M., Lim, E., Ellinor, P.T., January, C.T., Peterson, R.T., and Milan, D.J. (2011) Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen. Circulation. 123(1):23-30
Heuser, A., Plovie, E.R., Ellinor, P.T., Grossmann, K.S., Shin, J.T., Wichter, T., Basson, C.T., Lerman, B.B., Sasse-Klaassen, S., Thierfelder, L., MacRae, C.A., and Gerull, B. (2006) Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy. American journal of human genetics. 79(6):1081-1088
Milan, D.J., Jones, I.L., Ellinor, P.T., and MacRae, C.A. (2006) In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation. American journal of physiology. Heart and circulatory physiology. 291(1):H269-H273

NON-ZEBRAFISH PUBLICATIONS