ZFIN Person: Haass, Christian

ZFIN ID: ZDB-PERS-030923-9

Haass, Christian

URL:
Affiliation:
Address:	Adolf Butenandt Institute Department of Biochemistry Schillerstrasse 44 Muenchen , D-80336 Germany
Country:
Phone:	49-89-5996-471 or 49-89-5996-472
Fax:	49-89-5996-415
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962

Ohki, Y., Wenninger-Weinzierl, A., Hruscha, A., Asakawa, K., Kawakami, K., Haass, C., Edbauer, D., Schmid, B. (2017) Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration. Molecular neurodegeneration. 12:6

Eichner, R., Heider, M., Fernández-Sáiz, V., van Bebber, F., Garz, A.K., Lemeer, S., Rudelius, M., Targosz, B.S., Jacobs, L., Knorn, A.M., Slawska, J., Platzbecker, U., Germing, U., Langer, C., Knop, S., Einsele, H., Peschel, C., Haass, C., Keller, U., Schmid, B., Götze, K.S., Kuster, B., Bassermann, F. (2016) Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nature medicine. 22(7):735-43

Janssens, J., Philtjens, S., Kleinberger, G., Van Mossevelde, S., van der Zee, J., Cacace, R., Engelborghs, S., Sieben, A., Banzhaf-Strathmann, J., Dillen, L., Merlin, C., Cuijt, I., Robberecht, C., Schmid, B., Santens, P., Ivanoiu, A., Vandenbulcke, M., Vandenberghe, R., Cras, P., De Deyn, P.P., Martin, J.J., Maudsley, S., Haass, C., Cruts, M., Van Broeckhoven, C., Belgian Neurology (BELNEU) consortium (2015) Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains. Acta neuropathologica communications. 3:68

Solchenberger, B., Russell, C., Kremmer, E., Haass, C., Schmid, B. (2015) Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology. PLoS One. 10:e0118956

Hruscha, A., Krawitz, P., Rechenberg, A., Heinrich, V., Hecht, J., Haass, C., and Schmid, B. (2013) Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development (Cambridge, England). 140(24):4982-4987

van Bebber, F., Hruscha, A., Willem, M., Schmid, B., and Haass, C. (2013) Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. Journal of neurochemistry. 127(4):471-481

Schmid, B., and Haass, C. (2013) Genomic editing opens new avenues for zebrafish as a model for neurodegeneration. Journal of neurochemistry. 127(4):461-470

Fleck, D., van Bebber, F., Colombo, A., Galante, C., Schwenk, B.M., Rabe, L., Hampel, H., Novak, B., Kremmer, E., Tahirovic, S., Edbauer, D., Lichtenthaler, S.F., Schmid, B., Willem, M., and Haass, C. (2013) Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(18):7856-7869

Hogl, S., van Bebber, F., Dislich, B., Kuhn, P.H., Haass, C., Schmid, B., and Lichtenthaler, S.F. (2013) Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 13(9):1519-27

Schmid, B., Hruscha, A., Hogl, S., Banzhaf-Strathmann, J., Strecker, K., van der Zee, J., Teucke, M., Eimer, S., Hegermann, J., Kittelmann, M., Kremmer, E., Cruts, M., Solchenberger, B., Hasenkamp, L., van Bebber, F., Van Broeckhoven, C., Edbauer, D., Lichtenthaler, S.F., and Haass, C. (2013) Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 110(13):4986-91

Plucinska, G., Paquet, D., Hruscha, A., Godinho, L., Haass, C., Schmid, B., and Misgeld, T. (2012) In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(46):16203-16212

van Bebber, F., Paquet, D., Hruscha, A., Schmid, B., and Haass, C. (2010) Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiology of disease. 39(3):265-271

Dettmer, U., Kuhn, P.H., Abou-Ajram, C., Lichtenthaler, S.F., Krueger, M., Kremmer, E., Haass, C., and Haffner, C. (2010) Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex. The Journal of biological chemistry. 285(34):26174-26181

Dormann, D., Rodde, R., Edbauer, D., Bentmann, E., Fischer, I., Hruscha, A., Than, M.E., Mackenzie, I.R., Capell, A., Schmid, B., Neumann, M., and Haass, C. (2010) ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. The EMBO journal. 29(16):2841-2857

Fett, M.E., Pilsl, A., Paquet, D., van Bebber, F., Haass, C., Tatzelt, J., Schmid, B., and Winklhofer, K.F. (2010) Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model. PLoS One. 5(7):e11783

Paquet, D., Schmid, B., and Haass, C. (2010) Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo. Neuro-degenerative Diseases. 7(1-3):99-102

Paquet, D., Bhat, R., Sydow, A., Mandelkow, E.M., Berg, S., Hellberg, S., Fälting, J., Distel, M., Köster, R.W., Schmid, B., and Haass, C. (2009) A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J. Clin. Invest.. 119(5):1382-1395

Shankaran, S.S., Capell, A., Hruscha, A.T., Fellerer, K., Neumann, M., Schmid, B., and Haass, C. (2008) FTLD-U linked missense mutations in the progranulin gene reduce progranulin production and secretion. The Journal of biological chemistry. 283(3):1744-1753

Schiffer, N.W., Broadley, S.A., Hirschberger, T., Tavan, P., Kretzschmar, H.A.,Giese, A., Haass, C., Hartl, U.F., and Schmid, B. (2007) Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model. The Journal of biological chemistry. 282(12):9195-9203

Fluhrer, R., and Haass, C. (2007) Signal Peptide Peptidases and Gamma-Secretase: Cousins of the Same Protease Family?. Neuro-degenerative Diseases. 4(2-3):112-116

Haffner, C., and Haass, C. (2006) Cellular Functions of gamma-Secretase-Related Proteins. Neuro-degenerative Diseases. 3(4-5):284-289

Krawitz, P., Haffner, C., Fluhrer, R., Steiner, H., Schmid, B., and Haass, C. (2005) Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenlin in homologues SPPL2b and SPPL3. The Journal of biological chemistry. 280(47):39515-39523

Haffner, C., Frauli, M., Topp, S., Irmler, M., Hofmann, K., Regula, J.T., Bally-Cuif, L., and Haass, C. (2004) Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. The EMBO journal. 23(15):3041-3050

Haffner, C., and Haass, C. (2004) The Biochemical and Genetic Odyssey to the Function of a Nicastrin-Like Protein. Neuro-degenerative Diseases. 1(4-5):192-195

NON-ZEBRAFISH PUBLICATIONS